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Clinical Orthopaedics and Related Research®

Erschienen in:

01.10.2011 | Symposium: Clinically Relevant Strategies for Treating Cartilage and Meniscal Pathology

Cell-based Meniscal Tissue Engineering: A Case for Synoviocytes

verfasst von: Derek B. Fox, DVM, PhD, Diplomate ACVS, Jennifer J. Warnock, DVM, PhD, Diplomate ACVS

Erschienen in: Clinical Orthopaedics and Related Research® | Ausgabe 10/2011

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Abstract

Background

Avascular meniscal injuries are largely incapable of healing; the most common treatment remains partial meniscectomy despite the risk of subsequent osteoarthritis. Meniscal responses to injury are partially mediated through synovial activity and strategies have been investigated to encourage healing through stimulating or transplanting adjacent synovial lining. However, with their potential for chondrogenesis, synovial fibroblast-like stem cells hold promise for meniscal cartilage tissue engineering.

Questions/purposes

Thus, specific purposes of this review were to (1) examine how the synovial intima and synoviomeniscal junction affect current meniscal treatment modalities; and (2) examine the components of tissue engineering (cells, scaffolds, bioactive agents, and bioreactors) in the specific context of how cells of synovial origin may be used for meniscal healing or regeneration.

Methods

An online bibliographic search through PubMed was performed in March 2010. Studies were subjectively evaluated and reviewed if they addressed the question posed. Fifty-four resources were initially retrieved, which offered information on the chondrogenic potential of synovial-based cells that could prove valuable for meniscal fibrocartilage engineering.

Results

Based on the positive effects of adjoining synovium on meniscal healing as used in some current treatment modalities, the chondrogenic potential of fibroblast-like stem cells of synovial origin make this cell source a promising candidate for cell-based tissue engineering strategies.

Conclusions

The abundance of autologous synovial lining, its ability to regenerate, and the potential of synovial-derived stem cells to produce a wide spectrum of chondral matrix components make it an ideal candidate for future meniscal engineering investigations.

Ahmed AM, Burke DL. In vitro measurement of static pressure distribution in synovial joints: Part I. Tibial surface of the knee. J Biomech Eng. 1983;105:216–225.PubMedCrossRef

Andersson-Molina H, Karlsson H, Rockborn P. Arthroscopic partial and total meniscectomy: a long-term follow-up study with matched controls. Arthroscopy. 2002;18:183–189.PubMedCrossRef

Ando W, Tateishi K, Katakai D, Hart DA, Higuchi C, Nakata K, Hashimoto J, Fujie H, Shino K, Yoshikawa H, Nakamura N. In vitro generation of a scaffold-free tissue-engineered construct (TEC) derived from human synovial mesenchymal stem cells: biological and mechanical properties and further chondrogenic potential. Tissue Eng Part A. 2008;14:2041–2049.PubMedCrossRef

Arnoczky SP. Meniscus. In: Woo SLY, Buckwalter JA, eds. Injury and Repair of the Musculoskeletal Soft Tissues. Park Ridge, IL: American Academy of Orthopaedic Surgeons; 1988:483–537.

Arnoczky SP. Building a meniscus. Biological considerations Clin Orthop Relat Res. 1999;367(Suppl):S244–S253.CrossRef

Arnoczky SP, DiCarlo EF, O’Brien SJ, Warren RF. Cellular repopulation of deep-frozen meniscal autografts: an experimental study in the dog. Arthroscopy. 1992;8:428–436.PubMedCrossRef

Arnoczky SP, Warren RF. The microvasculature of the meniscus and its response to injury: an experimental study in the dog. Am J Sports Med. 1983;11:131–141.PubMedCrossRef

Arnoczky SP, Warren RF, McDevitt CA. Meniscal replacement using a cryopreserved allograft: an experimental study in the dog. Clin Orthop Relat Res. 1990;252:121–128.PubMed

Arnoczky SP, Warren RF, Spivak JM. Meniscal repair using an exogenous fibrin clot. J Bone Joint Surg Am. 1988;70:1209–1217.PubMed

10.

Bastow ER, Byers S, Golub SB, Clarkin CE, Pitsillides AA, Fosang AJ. Hyaluronan synthesis and degradation in cartilage and bone. Cell Mol Life Sci. 2008;65:395–413.PubMedCrossRef

11.

Biedert RM. Treatment of intrasubstance meniscal lesions: a randomized prospective study of four different methods. Knee Surg Sports Traumatol Arthrosc. 2000;8:104–108.PubMedCrossRef

12.

Bilgen B, Ren Y, Pei M, Aaron RK, Ciombor DM. CD 14-negative isolation enhances chondrogenesis in synovial fibroblasts. Tissue Eng Part A. 2009;15:3261–3270.PubMedCrossRef

13.

Burke DI, Ahmed AM. A biomechanical study of partial and total medial meniscectomy of the knee. Trans Orthop Res Soc. 1978;3:91.

14.

Canham W, Stanish W. A study of the biological behavior of the meniscus as a transplant in the medial compartment of a dog’s knee. Am J Sports Med. 1986;14:376–379.PubMedCrossRef

15.

Caubad HE, Rodkey WG, Fitzwater JE. Medial meniscus repairs. An experimental and morphologic study. Am J Sports Med. 1981;9:129–134.CrossRef

16.

Cheung HS. Distribution of type I, II, II and V in the pepsin solubilized collagen in bovine menisci. Connect Tissue Res. 1987;16:343–356.PubMedCrossRef

17.

Clark JM, Norman AG, Kaab MJ, Notzli HP. The surface contour of articular cartilage in an intact loaded joint. J Anat. 1999;195:45–46.PubMedCrossRef

18.

Cook JL, Fox DB. A novel bioabsorbable conduit augments healing of avascular meniscal tears in a dog model. Am J Sports Med. 2007;35:1877–1887.PubMedCrossRef

19.

Covall DJ, Wasilewski SA. Roentgenographic changes after arthroscopic meniscectomy: five year follow-up in patients more than 45 years old. Arthroscopy. 1992;8:242–246.PubMedCrossRef

20.

Cox JS, Nye CE, Schaefer WW. The degenerative effects of partial and total resection of the medial meniscus in dogs’ knees. Clin Orthop Relat Res. 1975;109:178–183.PubMedCrossRef

21.

Davies DV. The structure and functions of the synovial membrane. BMJ. 1950;1:92–95.PubMedCrossRef

22.

De Bari C, Dell’Accio F, Luyten FP. Failure of in vitro-differentiated mesenchymal stem cells from the synovial membrane to form ectopic stable cartilage in vivo. Arthritis Rheum. 2004;50:142–150.PubMedCrossRef

23.

De Bari C, Dell’Accio F, Tylzanowski P, Luyten FP. Multipotent mesenchymal stem cells from adult human synovial membrane. Arthritis Rheum. 2001;44:1928–1942.PubMedCrossRef

24.

DeYoung D, Flo GL, Tvedten H. Experimental medial meniscectomy in dogs undergoing cranial cruciate ligament repair. J Am Anim Hosp. 1980;16:639–645.

25.

Dijkgraaf LC, de Bont LG, Boering G, Liem RS. Function, biochemistry, and metabolism of the normal synovial membrane of the temporomandibular joint: a review of the literature. J Oral Maxillofac Surg. 1996;54:95–100.PubMedCrossRef

26.

Dijkgraaf LC, de Bont LG, Boering G, Liem RS. Structure of the normal synovial membrane of the temporomandibular joint: a review of the literature. J Oral Maxillofac Surg. 1996;54:332–338.PubMedCrossRef

27.

Dowthwaite GP, Ward AC, Flannely J, Suswillo RF, Flannery CR, Archer CW, Pisillides AA. The effect of mechanical strain on hyaluronan metabolism in embryonic fibrocartilage cells. Matrix Biol. 1999;18:523–532.PubMedCrossRef

28.

Fan J, Gong Y, Ren L, Varshney RR, Cai D, Wang DA. In vitro engineered cartilage using synovium-derived mesenchymal stem cells with injectable gellan hydrogels. Acta Biomaterials. 2010;6:1178–1185.CrossRef

29.

Fickert S, Fiedler J, Brenner RE. Identification, quantification and isolation of mesenchymal progenitor cells from osteoarthritic synovium by fluorescence automated cell sorting. Osteoarthritis Cartilage. 2003;11:790–800.PubMedCrossRef

30.

Forman SK, Oz MC, Lontz JF, Treat MR, Forman TA, Kiernan HA. Laser-assisted fibrin clot soldering of human menisci. Clin Orthop Relat Res. 1995;310:37–41.PubMed

31.

Fox DB, Cook JL, Arnoczky SP, Tomlinson JL, Kuroki K, Kreeger JM, Malaviya P. Fibrochondrogenesis of free intraarticular small intestinal submucosa scaffolds. Tissue Eng. 2004;10:129–137.PubMedCrossRef

32.

Fox DB, Cook JL, Kuroki K, Cockrell M. Effects of dynamic compressive load on collagen-based scaffolds seeded with fibroblast-like synoviocytes. Tissue Eng. 2006;12:1627–1637.CrossRef

33.

Fox DB, Luther JK, Whitener D. An in vitro model to assess mechanisms and efficacy of a cellular conduit for treatment of avascular meniscal injuries. In Vitro Cell Dev Biol Anim. 2008;44:185–188.PubMedCrossRef

34.

Fox DB, Warnock JJ, Stoker AM, Luther JK, Cockrell M. Effects of growth factors on equine synovial fibroblasts seeded on synthetic scaffolds for avascular meniscal tissue engineering. Res Vet Science. 2010;88:326–332.CrossRef

35.

Gershuni DH, Skyhar MJ, Danzig LA, Camp J, Hargens AR, Akeson WH. Experimental models to promote healing of tears in the avascular segment of canine menisci. J Bone Joint Surg Am. 1989;71:1363–1370.PubMed

36.

Goulding NJ, Dixey J, Morand EF, Dodds RA, Wilkinson LS, Pitsillides AA, Edwards JC. Differential distribution of annexins-I, -II, -IV, and -VI in synovium. Ann Rheum Dis. 1995;54:841–845.PubMedCrossRef

37.

Heatley FW. The meniscus—can it be repaired? An experimental investigation in rabbits. J Bone Joint Surg Br. 1980;62:397–402.PubMed

38.

Hede A, Larsen E. Sandberg H. Partial versus total meniscectomy: a prospective, randomized study with long-term follow-up. J Bone Joint Surg Br. 1992;74:118–121.PubMed

39.

Hede A, Larsen E. Sandberg H. The long term outcome of open total and partial meniscectomy related to the quantity and site of the meniscus removed. Int Orthop. 1992;16:122–125.PubMedCrossRef

40.

Henning CE, Lynch MA, Clark JR. Vascularity for healing of meniscus repairs. Arthroscopy. 1987;3:13–18.PubMedCrossRef

41.

Henning CE, Lynch MA, Yearout KM. Arthroscopic meniscal repair using an exogenous fibrin clot. Clin Orthop Relat Res. 1990;252:64–72.PubMed

42.

Henning CE, Yearout KM, Vequist SW, Stallbaumer RJ, Decker KA. Use of the fascia sheath coverage and exogenous fibrin clot in the treatment of complex meniscal tears. Am J Sports Med. 1991;19:626–631.PubMedCrossRef

43.

Hoben GM, Athanasiou KA. Meniscal repair with fibrocartilage engineering. Sports Med Arthrosc. 2006;14:129–137.PubMedCrossRef

44.

Horie M, Sekiya I, Muneta T, Ichinose S, Matsumoto K, Saito H, Murakami T, Kobayashi E. Intra-articular injected synovial stem cells differentiate into meniscal cells directly and promote meniscal regeneration without mobilization to distant organs in rat massive meniscal defects. Stem Cells. 2009;27:878–887.PubMedCrossRef

45.

Jisuiki J, Ochi M, Ikuta Y. Meniscal repair enhanced by an interpositional free synovial autograft: an experimental study in rabbits. Arthroscopy. 1994;10:659–666.CrossRef

46.

Jo CH, Ahn HJ, Kim HJ, Seong SC, Lee MC. Surface characterization and chondrogenic differentiation of mesenchymal stromal cells derived from synovium. Cytotherapy. 2007;9:316–327.PubMedCrossRef

47.

Kim JM, Moon MS. Effect of synovectomy upon regeneration of meniscus in rabbits. Clin Orthop Relat Res. 1979;141:287–294.PubMed

48.

Kimura M, Shirakura K, Hasegawa A, Kobuna Y, Niijima M. Second look arthroscopy after meniscal repair. Factors affecting the healing rate. Clin Orthop Relat Res. 1995;314:185–191.PubMed

49.

King D. The function of semilunar cartilages. J Bone Joint Surg. 1936;18:1069–1076.

50.

Koga H, Muneta T, Ju YJ, Nagase T, Nimura A, Mochizuki T, Ichinose S, Von Der Mark K, Sekiya I. Synovial stem cells are regionally specified according to local microenvironments after implantation for cartilage regeneration. Stem Cells. 2007;25:689–696.PubMedCrossRef

51.

Koga H, Muneta T, Nadase T, Nimura A, Ju YJ, Mochizuki T, Sekiya I. Comparison of mesenchymal tissues-derived stem cells for in vivo chondrogenesis: suitable conditions for cell therapy of cartilage defects in rabbit. Cell Tissue Res. 2008;333:207–215.PubMedCrossRef

52.

Kouri T, Heino J, Kroneld U. Surface membrane glycoproteins of macrophage-like synovial cells from rheumatoid and control patients. Scand J Immunol. 1984;19:359–364.PubMedCrossRef

53.

Kurth T, Hedbom E, Shintani N, Sugimoto M, Chen FH, Haspl M, Martinovic S, Hunziker EB. Chondrogenic potential of human synovial mesenchymal stem cells in alginate. Osteoarthritis Cartilage. 2007;15:1178–1189.PubMedCrossRef

54.

Levy IM, Torzilli PA, Warren RF. The effect of medial meniscectomy on anterior-posterior motion of the knee. J Bone Joint Surg Am. 1982;64:883–888.PubMed

55.

Linck G, Porte A. B-cells of the synovial membrane. III. Relationship with the specific collagenous structure of the intimal interstitium in the mouse. Cell Tissue Res. 1981;218:117–121.PubMedCrossRef

56.

Marsano A, Millward-Sadler SJ, Slater DM, Adesida A, Hardingham T, Tognana E, Kon E, Chiari-Grisar C, Nehrer S, Jakob M, Martin I. Differential cartilaginous tissue formation by human synovial membrane, fat pad, meniscus cells and articular chondrocytes. Osteoarthritis Cartilage. 2007;15:48–58.PubMedCrossRef

57.

McAndrews PT, Arnoczky SP. Meniscal repair enhancement techniques. Clin Sports Med. 1996;15:499–510.PubMed

58.

McCarthy EF, Dorfman HD. Primary synovial chondromatosis. An ultrastructural study. Clin Orthop Relat Res. 1982;168:178–186.PubMed

59.

McNicholas MJ, Rowley DI, McGurty D, Adalberth T, Abdon P, Lindstrand A, Lohmander LS. Total meniscectomy in adolescence: a thirty year follow up. J Bone Joint Surg Br. 2000;82:217–221.PubMedCrossRef

60.

Mizuno K, Muneta T, Morito T, Ichinose S, Koga H, Nimura A, Mochizuki T, Sekiya I. Exogenous synovial stem cells adhere to defect of meniscus and differentiate into cartilage cells. J Med Dent Sci. 2008;55:101–111.PubMed

61.

Nakano T, Dodd CM, Scott PG. Glycosaminoglycans and proteoglycans from different zones of the porcine knee meniscus. J Orthop Res. 1997;15:213–220.PubMedCrossRef

62.

Nishimura K, Solchaga LA, Caplan AI, Yoo JU, Goldberg VM, Johnstone B. Chondroprogenitor cells of synovial tissue. Arthritis Rheum. 1999;42:2631–2637.PubMedCrossRef

63.

Nimura A, Muneta T, Koga H, Mochizuki T, Suzuki K, Makino H, Umezawa A, Sekiya I. Increased proliferation of human synovial mesenchymal stem cells with autologous human serum. Comparisons with bone marrow mesenchymal stem cells and with fetal bovine serum. Arthritis Rheum. 2008;58:501–510.PubMedCrossRef

64.

Ochi M, Mochizuki Y, Deie M, Ikuta Y. Augmented meniscal healing with free synovial autografts: an organ culture model. Arch Orthop Trauma Surg. 1996;115:123–126.PubMedCrossRef

65.

Ostergaard M, Ejbjerg B, Stoltenberg M, Gideon P, Volck B, Skov K, Jensen CH, Lorenzen I. Quantitative magnetic resonance imaging as marker of synovial membrane regeneration and recurrence of synovitis after arthroscopic knee joint synovectomy: a one year follow up study. Ann Rheum Dis. 2001;60:233–236.PubMedCrossRef

66.

Park Y, Sugimoto M, Watrin A, Chiquet M, Hunziker EB. BMP-2 induces the expression of chondrocyte-specific genes in bovine synovium-derived progenitor cells cultures in three-dimensional alginate hydrogel. Osteoarthritis Cartilage. 2005;13:527–536.PubMedCrossRef

67.

Pei M, He F, Boyuce CM, Kish VL. Repair of full-thickness femoral condyle cartilage defects using allogeneic synovial cell-engineered tissue constructs. Osteoarthritis Cartilage. 2009;17:714–722.PubMedCrossRef

68.

Pei M, He F, Chen D, Vunjak-Novakovic G. Synovium-derived stem cell-based chondrogenesis. Differentiation. 2008;76:1044–1056.PubMedCrossRef

69.

Praemer A, Furner S, Rice DP. Musculoskeletal Conditions in the United States. Rosemont, IL: American Academy of Orthopaedic Surgeons; 1999.

70.

Ritchie JR, Miller MD, Bents RT, Smith DK. Meniscal repair in the goat model. The use of healing adjuncts on central tears and the role of magnetic resonance arthrography in repair evaluation. Am J Sports Med. 1998;26:278–284.PubMed

71.

Rodeo SA, Seneviratne A, Suzuki K, Felker K, Wickiewicz TL, Warren RF. Histological analysis of human meniscal allografts: a preliminary report. J Bone Joint Surg Am. 2000;82:1071–1082.PubMed

72.

Sakaguchi Y, Sekiya I, Yagishita K, Muneta T. Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source. Arthritis Rheum. 2005;52:2521–2529.PubMedCrossRef

73.

Sakao K, Takahashi KA, Arai Y, Inoue A, Tonomura H, Saito M, Yamamoto T, Kanamura N, Imnishi J, Mazda O, Kubo T. Induction of chondrogenic phenotype in synovium-derived progenitor cells by intermittent hydrostatic pressure. Osteoarthritis Cartilage. 2008;16:805–814.PubMedCrossRef

74.

Sakimura K, Matsumoto T, Miyamoto C, Osaki M, Shindo H. Effects of insulin-like growth factor I on transforming growth factor β1 induced chondrogenesis of synovium-derived mesenchymal stem cells cultured in a polyglycolic acid scaffold. Cells Tissue Organs. 2006;183:55–61.CrossRef

75.

Schimmer RD, Brulhart KB, Duff C, Ginz W. Arthroscopic partial meniscectomy: a 12 year follow-up and two-step evaluation of the long-term course. Arthroscopy. 1998;14:136–142.PubMedCrossRef

76.

Sethi PM, Cooper A, Joki P. Technical tips in orthopaedics: meniscal repair with use of an in situ fibrin clot. Arthroscopy. 2003;19:E44.PubMed

77.

Sgaglione NA, Steadman JR, Shaffer B, Miller MD, Fu FH. Current concepts in meniscus surgery: resection to replacement. Arthrosocopy. 2003;19(Suppl 1):161–188.CrossRef

78.

Sherman MF, Warren RF, Marshall JL, Savatsky GJ. A clinical and radiographical analysis of 127 anterior cruciate insufficient knees. Clin Orthop Relat Res. 1988;227:229–237.PubMed

79.

Shirakura K, Niijima M, Kobuna Y, Kizuki S. Free synovium promotes meniscal healing. Synovium muscle and synthetic mesh compared in dogs. Acta Orthop Scand. 1997;68:51–54.PubMedCrossRef

80.

Shirasawa A, Sekiya I, Sakaguchi Y, Yagashita K, Ichinose S, Muneta T. In vitro chondrogenesis of human synovium-derived mesenchymal stem cells: optimal condition and comparison with bone marrow-derived cells. J Cell Biochem. 2006;97:84–97.PubMedCrossRef

81.

Shoemaker SC, Markolf KL. The role of the meniscus in the anterior-posterior stability of the loaded anterior cruciate-deficient knee. J Bone Joint Surg Am. 1986;68:71–79.PubMed

82.

Swann DA, Silver FH, Slayter HS, Stafford W, Shore E. The molecular structure and lubricating activity of lubricin isolated from bovine and human synovial fluids. Biochem J. 1985;225:195–201.PubMed

83.

Swann DA, Slayter HS, Silver FH. The molecular structure of lubricating glycoprotein-I, the boundary lubricant for articular cartilage. J Biol Chem. 1981;256:5921–5925.PubMed

84.

Tan Y, Zhang Y, Pei M. Meniscus reconstruction through coculturing meniscus cells with synovium-derived stem cells on small intestine submucosa—a pilot study to engineer meniscus tissue constructs. Tissue Eng Part A. 16;1:67–79.

85.

Tateishi K, Ando W, Higuchi C, Hart DA, Hashimoto J, Nakata K, Yoshikawa H, Nakamura N. Comparison of human serum with fetal bovine serum for expansion and differentiation of human synovial MSC: potential feasibility for clinical applications. Cell Transplant. 2008;17:549–557.PubMedCrossRef

86.

Tateishi K, Ando W, Yonetani Y, Nakata K, Hashimoto J, Higuchi C, Tanaka Y, Yoshikawa H, Nakamura N. Meniscal repair using scaffold-free 3D synthetic tissue (3DST) derived from synovium. Trans Orthop Res Soc. 2007;32:781.

87.

Tateishi K, Higuchi C, Ando W, Nakata K, Hashimoto J, Hart DA, Yoshikawa H, Nakamura N. The immunosuppressant FK506 promotes development of the chondrogenic phenotype in human synovial stromal cells via modulation of the Smad signaling pathway. Osteoarthritis Cartilage. 2007;15:709–718.PubMedCrossRef

88.

Uchio Y, Ochi M, Adachi N, Kawasaki K, Iwasa J. Results of rasping of meniscal tears and without anterior cruciate ligament injury as evaluated by second-look arthroscopy. Arthroscopy. 2003;19:463–469.PubMedCrossRef

89.

van Trommel MF, Simonian PT, Potter HG, Wickiewicz TL. Arthroscopic meniscal repair with fibrin clot of complete radial tears of the lateral meniscus in the avascular zone. Arthroscopy. 1998;14:360–365.PubMedCrossRef

90.

Vandenabeele F, De Bari C, Moreels M, Lambrichts I, Dell’Accio F, Lippens PL, Luyten FP. Morphological and immunocytochemical characterization of cultured fibroblast-like cells derived from adult human synovial membrane. Arch Histol Cytol. 2003;66:145–153.PubMedCrossRef

91.

Voloshin AS, Wosk J. Shock absorption of meniscectomized and painful knees: a comparative in vivo study. J Biomed Eng. 1983;5:157–161.PubMedCrossRef

92.

Webber RJ, York JL, Vanderschilden JL, Hough AJ. An organ culture model for assaying wound repair of the fibrocartilaginous knee joint meniscus. Am J Sports Med. 1989;17:393–400.PubMedCrossRef

93.

Xue C, Takahashi M, Hasunuma T, Aona H, Yamamoto K, Yoshino S, Sumida T, Nishioka K. Characterisation of fibroblast-like cells in pannus lesions of patients with rheumatoid arthritis sharing properties of fibroblasts and chondrocytes. Ann Rheum Dis. 1997;56:262–267.PubMedCrossRef

94.

Yokoyama A, Sekiya I, Miyazaki K, Ichinose S, Hata Y, Muneta T. In vitro cartilage formation of composites of synovium-derived mesenchymal stem cells with collagen gel. Cell Tissue Res. 2005;322:289–298.PubMedCrossRef

95.

Yoshimura H, Muneta T, Nimura A, Yokoyama A, Koga H, Sekiya I. Comparison of rat mesenchymal stem cells derived from bone marrow, synovium, periosteum, adipose tissue, and muscle. Cell Tissue Res. 2007;327:449–462.PubMedCrossRef

96.

Zhang Z, Arnold JA. Trephination and suturing of avascular meniscal tears: a clinical study of the trephination procedure. Arthroscopy. 1996;12:726–731.PubMedCrossRef

97.

Zhang Z, Arnold JA, Williams T, McCann B. Repairs by trephination and suturing of longitudinal injuries in the avascular area of the meniscus in goats. Am J Sports Med. 1995;23:35–41.PubMedCrossRef

98.

Zimny ML, Albright DJ, Dabezies E. Mechanoreceptors in the human medial meniscus. Acta Anat (Basel). 1988;133:35–40.CrossRef

Titel: Cell-based Meniscal Tissue Engineering: A Case for Synoviocytes
verfasst von: Derek B. Fox, DVM, PhD, Diplomate ACVS
Jennifer J. Warnock, DVM, PhD, Diplomate ACVS
Publikationsdatum: 01.10.2011
Verlag: Springer-Verlag
Erschienen in: Clinical Orthopaedics and Related Research® / Ausgabe 10/2011
Print ISSN: 0009-921X
Elektronische ISSN: 1528-1132
DOI: https://doi.org/10.1007/s11999-011-1824-z

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