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NeuroMolecular Medicine

Erschienen in:

01.09.2009 | Review Paper

MicroRNAs in Adult and Embryonic Neurogenesis

verfasst von: Changmei Liu, Xinyu Zhao

Erschienen in: NeuroMolecular Medicine | Ausgabe 3/2009

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Abstract

Neurogenesis is defined as a process that includes the proliferation of neural stem/progenitor cells (NPCs) and the differentiation of these cells into new neurons that integrate into the existing neuronal circuitry. MicroRNAs (miRNAs) are a recently discovered class of small non-protein coding RNA molecules implicated in a wide range of diverse gene regulatory mechanisms. More and more data demonstrate that numerous miRNAs are expressed in a spatially and temporally controlled manners in the nervous system, which suggests that miRNAs have important roles in the gene regulatory networks involved in both brain development and adult neural plasticity. This review summarizes the roles of miRNAs-mediated gene regulation in the nervous system with focus on neurogenesis in both embryonic and adult brains.

Ahn, S., & Joyner, A. L. (2005). In vivo analysis of quiescent adult neural stem cells responding to sonic hedgehog. Nature, 437, 894–897.PubMedCrossRef

Alonso, M., Viollet, C., Gabellec, M. M., Meas-Yedid, V., Olivo-Marin, J. C., & Lledo, P. M. (2006). Olfactory discrimination learning increases the survival of adult-born neurons in the olfactory bulb. Journal of Neuroscience, 26, 10508–10513.PubMedCrossRef

Balordi, F., & Fishell, G. (2007). Hedgehog signaling in the subventricular zone is required for both the maintenance of stem cells and the migration of newborn neurons. Journal of Neuroscience, 27, 5936–5947.PubMedCrossRef

Barkho, B. Z., Munoz, A. E., Li, X., Li, L., Cunningham, L. A., & Zhao, X. (2008). Endogenous matrix metalloproteinase (MMP)-3 and MMP-9 promote the differentiation and migration of adult neural progenitor cells in response to chemokines. Stem Cells, 26, 3139–3149.PubMedCrossRef

Bartel, D. P. (2004). MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell, 116, 281–297.PubMedCrossRef

Borchert, G. M., Lanier, W., & Davidson, B. L. (2006). RNA polymerase III transcribes human microRNAs. Nature Structural and Molecular Biology, 13, 1097–1101.PubMedCrossRef

Burns, K. A., Ayoub, A. E., Breunig, J. J., Adhami, F., Weng, W. L., Colbert, M. C., et al. (2007). Nestin-CreER mice reveal DNA synthesis by nonapoptotic neurons following cerebral ischemia-hypoxia. Cerebral Cortex, 17, 2585–2592.PubMedCrossRef

Cameron, H. A., Tanapat, P., & Gould, E. (1998). Adrenal steroids and N-methyl-D-aspartate receptor activation regulate neurogenesis in the dentate gyrus of adult rats through a common pathway. Neuroscience, 82, 349–354.PubMedCrossRef

Carthew, R. W., & Sontheimer, E. J. (2009). Origins and mechanisms of miRNAs and siRNAs. Cell, 136, 642–655.PubMedCrossRef

Chalfie, M., Horvitz, H. R., & Sulston, J. E. (1981). Mutations that lead to reiterations in the cell lineages of C. elegans. Cell, 24, 59–69.PubMedCrossRef

Chen, C., Ridzon, D. A., Broomer, A. J., Zhou, Z., Lee, D. H., Nguyen, J. T., et al. (2005). Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Research, 33, e179.PubMedCrossRef

Cheng, L. C., Pastrana, E., Tavazoie, M., & Doetsch, F. (2009). miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche. Nature Neuroscience, 12, 399–408.PubMedCrossRef

Chi, S. W., Zang, J. B., Mele, A., & Darnell, R. B. (2009). Argonaute HITS-CLIP decodes microRNA–mRNA interaction maps. Nature [Epub ahead of print].

Choi, P. S., Zakhary, L., Choi, W. Y., Caron, S., Alvarez-Saavedra, E., Miska, E. A., et al. (2008). Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron, 57, 41–55.PubMedCrossRef

Conaco, C., Otto, S., Han, J. J., & Mandel, G. (2006). Reciprocal actions of REST and a microRNA promote neuronal identity. Proceedings of the National Academy of Sciences of the United States of America, 103, 2422–2427.PubMedCrossRef

Corbin, J. G., Gaiano, N., Juliano, S. L., Poluch, S., Stancik, E., & Haydar, T. F. (2008). Regulation of neural progenitor cell development in the nervous system. Journal of Neurochemistry, 106, 2272–2287.PubMedCrossRef

Curtis, M. A., Kam, M., Nannmark, U., Anderson, M. F., Axell, M. Z., Wikkelso, C., et al. (2007). Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension. Science, 315, 1243–1249.PubMedCrossRef

Devor, E. J., Huang, L., Abdukarimov, A., & Abdurakhmonov, I. Y. (2009). Methodologies for in vitro cloning of small RNAs and application for plant genome(s). International Journal of Plant Genomics, 2009, 915061.PubMedCrossRef

Doetsch, F. (2003). A niche for adult neural stem cells. Current Opinion in Genetics and Development, 13, 543–550.PubMedCrossRef

Duan, X., Chang, J. H., Ge, S., Faulkner, R. L., Kim, J. Y., Kitabatake, Y., et al. (2007). Disrupted-in-schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell, 130, 1146–1158.PubMedCrossRef

Dupret, D., Revest, J. M., Koehl, M., Ichas, F., De Giorgi, F., Costet, P., et al. (2008). Spatial relational memory requires hippocampal adult neurogenesis. PLoS ONE, 3, e1959.PubMedCrossRef

Eriksson, P. S., Perfilieva, E., Bjork-Eriksson, T., Alborn, A. M., Nordborg, C., Peterson, D. A., et al. (1998). Neurogenesis in the adult human hippocampus. Nature Medicine, 4, 1313–1317.PubMedCrossRef

Ferri, A. L. M., Cavallaro, M., Braida, D., Di Cristofano, A., Canta, A., Vezzani, A., et al. (2004). Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain. Development, 131, 3805–3819.PubMedCrossRef

Fiore, R., Siegel, G., & Schratt, G. (2008). MicroRNA function in neuronal development, plasticity and disease. Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1779, 471–478.CrossRef

Gentner, B., Schira, G., Giustacchini, A., Amendola, M., Brown, B. D., Ponzoni, M., et al. (2009). Stable knockdown of microRNA in vivo by lentiviral vectors. Nature Methods, 6, 63–66.PubMedCrossRef

Giraldez, A. J., Cinalli, R. M., Glasner, M. E., Enright, A. J., Thomson, J. M., Baskerville, S., et al. (2005). MicroRNAs regulate brain morphogenesis in zebrafish. Science, 308, 833–838.PubMedCrossRef

Graham, V., Khudyakov, J., Ellis, P., & Pevny, L. (2003). SOX2 functions to maintain neural progenitor identity. Neuron, 39, 749–765.PubMedCrossRef

Gritti, A., Frolichsthal-Schoeller, P., Galli, R., Parati, E. A., Cova, L., Pagano, S. F., et al. (1999). Epidermal and fibroblast growth factors behave as mitogenic regulators for a single multipotent stem cell-like population from the subventricular region of the adult mouse forebrain. Journal of Neuroscience, 19, 3287–3297.PubMed

Hafner, M., Landgraf, P., Ludwig, J., Rice, A., Ojo, T., Lin, C., et al. (2008). Identification of microRNAs and other small regulatory RNAs using cDNA library sequencing. Methods, 44, 3–12.PubMedCrossRef

Houbaviy, H. B., Dennis, L., Jaenisch, R., & Sharp, P. A. (2005). Characterization of a highly variable eutherian microRNA gene. RNA, 11, 1245–1257.PubMedCrossRef

Houbaviy, H. B., Murray, M. F., & Sharp, P. A. (2003). Embryonic stem cell-specific microRNAs. Developmental Cell, 5, 351–358.PubMedCrossRef

Imayoshi, I., Sakamoto, M., Ohtsuka, T., Takao, K., Miyakawa, T., Yamaguchi, M., et al. (2008). Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nature Neuroscience, 11, 1153–1161.PubMedCrossRef

Jessberger, S., Clark, R. E., Broadbent, N. J., Clemenson, G. D., Consiglio, A., Lie, D. C., et al. (2009). Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. Learning and Memory, 16, 147–154.PubMedCrossRef

Jin, K. L., Wang, X. M., Xie, L., Mao, X. O., Zhu, W., Wang, Y., et al. (2006). Evidence for stroke-induced neurogenesis in the human brain. Proceedings of the National Academy of Sciences of the United States of America, 103, 13198–13202.PubMedCrossRef

Kanellopoulou, C., Muljo, S. A., Kung, A. L., Ganesan, S., Drapkin, R., Jenuwein, T., et al. (2005). Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes and Development, 19, 489–501.PubMedCrossRef

Kapsimali, M., Kloosterman, W. P., de Bruijn, E., Rosa, F., Plasterk, R. H. A., & Wilson, S. W. (2007). MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system. Genome Biology, 8, R173.PubMedCrossRef

Keller, G. (2005). Embryonic stem cell differentiation: Emergence of a new era in biology and medicine. Genes and Development, 19, 1129–1155.PubMedCrossRef

Keller, G., Kennedy, M., Papayannopoulou, T., & Wiles, M. V. (1993). Hematopoietic commitment during embryonic stem-cell differentiation in culture. Molecular and Cellular Biology, 13, 473–486.PubMed

Kempermann, G., & Kronenberg, G. (2003). Depressed new neurons—Adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression. Biological Psychiatry, 54, 499–503.PubMedCrossRef

Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997). More hippocampal neurons in adult mice living in an enriched environment. Nature, 386, 493–495.PubMedCrossRef

Kennedy, M., & Keller, G. M. (2003). Hematopoietic commitment of ES cells in culture. Differentiation of Embryonic Stem Cells, 365, 39–59.CrossRef

Kilpatrick, T. J., & Bartlett, P. F. (1993). Cloning and growth of multipotential neural precursors—Requirements for proliferation and differentiation. Neuron, 10, 255–265.PubMedCrossRef

Kim, V. N., Han, J., & Siomi, M. C. (2009). Biogenesis of small RNAs in animals. Nature Reviews Molecular Cell Biology, 10, 126–139.PubMedCrossRef

Kim, J., Inoue, K., Ishii, J., Vanti, W. B., Voronov, S. V., Murchison, E., et al. (2007). A microRNA feedback circuit in midbrain dopamine neurons. Science, 317, 1220–1224.PubMedCrossRef

Kim, J., Krichevsky, A., Grad, Y., Hayes, G. D., Kosik, K. S., Church, G. M., et al. (2004). Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proceedings of the National Academy of Sciences of the United States of America, 101, 360–365.PubMedCrossRef

Kornack, D. R., & Rakic, P. (2001). The generation, migration, and differentiation of olfactory neurons in the adult primate brain. Proceedings of the National Academy of Sciences of the United States of America, 98, 4752–4757.PubMedCrossRef

Krichevsky, A. M., Sonntag, K. C., Isacson, O., & Kosik, K. S. (2006). Specific microRNAs modulate embryonic stem cell-derived neurogenesis. Stem Cells, 24, 857–864.PubMedCrossRef

Lagace, D. C., Whitman, M. C., Noonan, M. A., Ables, J. L., DeCarolis, N. A., Arguello, A. A., et al. (2007). Dynamic contribution of nestin-expressing stem cells to adult neurogenesis. Journal of Neuroscience, 27, 12623–12629.PubMedCrossRef

Lagos-Quintana, M., Rauhut, R., Yalcin, A., Meyer, J., Lendeckel, W., & Tuschl, T. (2002). Identification of tissue-specific microRNAs from mouse. Current Biology, 12, 735–739.PubMedCrossRef

Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., et al. (2007). A mammalian microRNA expression atlas based on small RNA library sequencing. Cell, 129, 1401–1414.PubMedCrossRef

Larson, J., Jessen, R. E., Kim, D., Fine, A. K. S., & du Hoffmann, J. (2005). Age-dependent and selective impairment of long-term potentiation in the anterior piriform cortex of mice lacking the fragile X mental retardation protein. Journal of Neuroscience, 25, 9460–9469.PubMedCrossRef

Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993). The C. elegans Heterochronic gene Lin-4 encodes small RNAS with antisense complementarity to Lin-14. Cell, 75, 843–854.PubMedCrossRef

Li, X., Barkho, B. Z., Luo, Y., Smrt, R. D., Santistevan, N. J., Liu, C., et al. (2008). Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. Journal of Biological Chemistry, 283, 27644–27652.PubMedCrossRef

Li, O., Li, J. M., & Droge, P. (2007). DNA architectural factor and proto-oncogene HMGA2 regulates key developmental genes in pluripotent human embryonic stem cells. FEBS Letters, 581, 3533–3537.PubMedCrossRef

Li, O., Vasudevan, D., Davey, C. A., & Droge, P. (2006). High-level expression of DNA architectural factor HMGA2 and its association with nucleosomes in human embryonic stem cells. Genesis, 44, 523–529.PubMedCrossRef

Li, X. K., & Zhao, X. Y. (2008). Epigenetic regulation of mammalian stem cells. Stem Cells and Development, 17, 1043–1052.PubMedCrossRef

Lie, D. C., Dziewczapolski, G., Willhoite, A. R., Kaspar, B. K., Shults, C. W., & Gage, F. H. (2002). The adult substantia nigra contains progenitor cells with neurogenic potential. Journal of Neuroscience, 22, 6639–6649.PubMed

Lu, Y., Thomson, J. M., Wong, H. Y. F., Hammond, S. M., & Hogan, B. L. M. (2007). Transgenic over-expression of the microRNA miR-17–92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. Developmental Biology, 310, 442–453.PubMedCrossRef

Lytle, J. R., Yario, T. A., & Steitz, J. A. (2007). Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5′ UTR as in the 3′ UTR. Proceedings of the National Academy of Sciences of the United States of America, 104, 9667–9672.PubMedCrossRef

Makeyev, E. V., Zhang, J. W., Carrasco, M. A., & Maniatis, T. (2007). The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative Pre-mRNA splicing. Molecular Cell, 27, 435–448.PubMedCrossRef

Martin, G. R. (1981). Isolation of a pluripotent cell-line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem-cells. Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences, 78, 7634–7638.CrossRef

Mayoral, R. J., Pipkin, M. E., Pachkov, M., van Nimwegen, E., Rao, A., & Monticelli, S. (2009). MicroRNA-221–222 regulate the cell cycle in mast cells. Journal of Immunology, 182, 433–445.

Mellios, N., Huang, H. S., Grigorenko, A., Rogaev, E., & Akbarian, S. (2008). A set of differentially expressed miRNAs, including miR-30a–5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex. Human Molecular Genetics, 17, 3030–3042.PubMedCrossRef

Molofsky, A. V., Pardal, R., Iwashita, T., Park, I. K., Clarke, M. F., & Morrison, S. J. (2003). Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature, 425, 962–967.PubMedCrossRef

Morozova, O., & Marra, M. A. (2008). Applications of next-generation sequencing technologies in functional genomics. Genomics, 92, 255–264.PubMedCrossRef

Morshead, C. M., Reynolds, B. A., Craig, C. G., Mcburney, M. W., Staines, W. A., Morassutti, D., et al. (1994). Neural stem-cells in the adult mammalian forebrain—a relatively quiescent subpopulation of subependymal cells. Neuron, 13, 1071–1082.PubMedCrossRef

Mott, J. L., Kobayashi, S., Bronk, S. F., & Gores, G. J. (2007). mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene, 26, 6133–6140.PubMedCrossRef

Nishino, J., Kim, I., Chada, K., & Morrison, S. J. (2008). Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf expression. Cell, 135, 227–239.PubMedCrossRef

Noctor, S. C., Martinez-Cerdeno, V., Ivic, L., & Kriegstein, A. R. (2004). Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases. Nature Neuroscience, 7, 136–144.PubMedCrossRef

Orom, U. A., Nielsen, F. C., & Lund, A. H. (2008). MicroRNA-10a binds the 5′ UTR of ribosomal protein mRNAs and enhances their translation. Molecular Cell, 30, 460–471.PubMedCrossRef

Packer, A. N., Xing, Y., Harper, S. Q., Jones, L., & Davidson, B. L. (2008). The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington’s disease. Journal of Neuroscience, 28, 14341–14346.PubMedCrossRef

Palmer, T. D., Markakis, E. A., Willhoite, A. R., Safar, F., & Gage, F. H. (1999). Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS. Journal of Neuroscience, 19, 8487–8497.PubMed

Palmer, T. D., Takahashi, J., & Gage, F. H. (1997). The adult rat hippocampus contains primordial neural stem cells. Molecular and Cellular Neuroscience, 8, 389–404.PubMedCrossRef

Parent, J. M., Yu, T. W., Leibowitz, R. T., Geschwind, D. H., Sloviter, R. S., & Lowenstein, D. H. (1997). Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. Journal of Neuroscience, 17, 3727–3738.PubMed

Pencea, V., Bingaman, K. D., Freedman, L. J., & Luskin, M. B. (2001). Neurogenesis in the subventricular zone and rostral migratory stream of the neonatal and adult primate forebrain. Experimental Neurology, 172, 1–16.PubMedCrossRef

Pomraning, K. R., Smith, K. M., & Freitag, M. (2009). Genome-wide high throughput analysis of DNA methylation in eukaryotes. Methods, 47, 142–150.PubMedCrossRef

Reynolds, B. A., Tetzlaff, W., & Weiss, S. (1992). A multipotent Egf-responsive striatal embryonic progenitor-cell produces neurons and astrocytes. Journal of Neuroscience, 12, 4565–4574.PubMed

Sanosaka, T., Namihira, M., & Nakashima, K. (2009). Epigenetic mechanisms in sequential differentiation of neural stem cells. Epigenetics, 4, 89–92.PubMedCrossRef

Schratt, G. M., Tuebing, F., Nigh, E. A., Kane, C. G., Sabatini, M. E., Kiebler, M., et al. (2006). A brain-specific microRNA regulates dendritic spine development. Nature, 439, 283–289. (Erratum in Nature 441, 902).PubMedCrossRef

Sempere, L. F., Freemantle, S., Pitha-Rowe, I., Moss, E., Dmitrovsky, E., & Ambros, V. (2004). Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biology, 5, R13.PubMedCrossRef

Shi, Y. H., Lie, D. C., Taupin, P., Nakashima, K., Ray, J., Yu, R. T., et al. (2004). Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature, 427, 78–83.PubMedCrossRef

Shihabuddin, L. S., Horner, P. J., Ray, J., & Gage, F. H. (2000). Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus. Journal of Neuroscience, 20, 8727–8735.PubMed

Shimozaki, K., Namihira, M., Nakashima, K., & Taga, T. (2005). Stage- and site-specific DNA demethylation during neural cell development from embryonic stem cells. Journal of Neurochemistry, 93, 432–439.PubMedCrossRef

Suh, M. R., Lee, Y., Kim, J. Y., Kim, S. K., Moon, S. H., Lee, J. Y., et al. (2004). Human embryonic stem cells express a unique set of microRNAs. Developmental Biology, 270, 488–498.PubMedCrossRef

Sun, Y. J., Jin, K. L., Childs, J. T., Xie, L., Mao, X. O., & Greenberg, D. A. (2005). Neuronal nitric oxide synthase and ischemia-induced neurogenesis. Journal of Cerebral Blood Flow and Metabolism, 25, 485–492.PubMedCrossRef

Tay, Y., Zhang, J. Q., Thomson, A. M., Lim, B., & Rigoutsos, I. (2008). MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature, 455, 1124.PubMedCrossRef

Temple, S. (2001). The development of neural stem cells. Nature, 414, 112–117.PubMedCrossRef

Thai, T. H., Calado, D. P., Casola, S., Ansel, K. M., Xiao, C. C., Xue, Y. Z., et al. (2007). Regulation of the germinal center response by microRNA-155. Science, 316, 604–608.PubMedCrossRef

Vasudevan, S., Tong, Y., & Steitz, J. A. (2007). Switching from repression to activation: microRNAs can up-regulate translation. Science, 318, 1931–1934.PubMedCrossRef

Visvanathan, J., Lee, S., Lee, B., Lee, J. W., & Lee, S. K. (2007). The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development. Genes and Development, 21, 744–749.PubMedCrossRef

Wang, S. S., Aurora, A. B., Johnson, B. A., Qi, X. X., McAnally, J., Hill, J. A., et al. (2008a). The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Developmental Cell, 15, 261–271.PubMedCrossRef

Wang, Y., Baskerville, S., Shenoy, A., Babiarz, J. E., Baehner, L., & Blelloch, R. (2008b). Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation. Nature Genetics, 40, 1478–1483.PubMedCrossRef

Wang, Y. L., Keys, D. N., Au-Young, J. K., & Chen, C. F. (2009). MicroRNAs in embryonic stem cells. Journal of Cellular Physiology, 218, 251–255.PubMedCrossRef

Wang, Y. M., Medvid, R., Melton, C., Jaenisch, R., & Blelloch, R. (2007). DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nature Genetics, 39, 380–385.PubMedCrossRef

Weiss, S., Dunne, C., Hewson, J., Wohl, C., Wheatley, M., Peterson, A. C., et al. (1996). Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis. Journal of Neuroscience, 16, 7599–7609.PubMed

Williams, A. E. (2008). Functional aspects of animal microRNAs. Cellular and Molecular Life Sciences, 65, 545–562.PubMedCrossRef

Xu, J., Zeng, J. Q., Wan, G., Hu, G. B., Yan, H., & Ma, L. X. (2009). Construction of siRNA/miRNA expression vectors based on a one-step PCR process. BMC Biotechnology, 9, 53.PubMedCrossRef

Yu, J. Y., Chung, K. H., Deo, M., Thompson, R. C., & Turner, D. L. (2008). MicroRNA miR-124 regulates neurite outgrowth during neuronal differentiation. Experimental Cell Research, 314, 2618–2633.PubMedCrossRef

Yu, F., Yao, H., Zhu, P. C., Zhang, X. Q., Pan, Q. H., Gong, C., et al. (2007). Iet-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell, 131, 1109–1123.PubMedCrossRef

Zhao, C. M., Deng, W., & Gage, F. H. (2008a). Mechanisms and functional implications of adult neurogenesis. Cell, 132, 645–660.PubMedCrossRef

Zhao, J. J., Lin, J. H., Yang, H., Kong, W., He, L. L., Ma, X., et al. (2008b). MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer. Journal of Biological Chemistry, 283, 31079–31086.PubMedCrossRef

Zhao, C., Sun, G., Li, S., & Shi, Y. (2009). A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination. Nature Structural and Molecular Biology, 16, 365–371.PubMedCrossRef

Zhao, X., Ueba, T., Christie, B. R., Barkho, B., McConnell, M. J., Nakashima, K., et al. (2003). Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proceedings of the National Academy of Sciences of the United States of America, 100, 6777–6782.PubMedCrossRef

Titel: MicroRNAs in Adult and Embryonic Neurogenesis
verfasst von: Changmei Liu
Xinyu Zhao
Publikationsdatum: 01.09.2009
Verlag: Humana Press Inc
Erschienen in: NeuroMolecular Medicine / Ausgabe 3/2009
Print ISSN: 1535-1084
Elektronische ISSN: 1559-1174
DOI: https://doi.org/10.1007/s12017-009-8077-y

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