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NeuroMolecular Medicine

NeuroMolecular Medicine OnlineFirst articles

07.07.2020 | Original Paper

Experimentally Induced Sepsis Causes Extensive Hypomyelination in the Prefrontal Cortex and Hippocampus in Neonatal Rats

Neonatal sepsis is associated with cognitive deficit in the later life. Axonal myelination plays a pivotal role in neurotransmission and formation of learning and memory. This study aimed to explore if systemic lipopolysaccharide (LPS) injection …

07.07.2020 | Original Paper

A Tellurium-Based Small Immunomodulatory Molecule Ameliorates Depression-Like Behavior in Two Distinct Rat Models

Major depressive disorder (MDD) is a leading cause of morbidity, and the fourth leading cause of disease burden worldwide. While MDD is a treatable condition for many individuals, others suffer from treatment-resistant depression (TRD). Here, we …

12.05.2020 | Review

Application of Next-Generation Sequencing in Neurodegenerative Diseases: Opportunities and Challenges

Genetic factors (gene mutations) lead to various rare and prevalent neurological diseases. Identification of underlying mutations in neurodegenerative diseases is of paramount importance due to the heterogeneous nature of the genome and different …

09.05.2020 | Original Paper

miR-146a Mimics Ameliorates Traumatic Brain Injury Involving JNK and NF-κB Signaling Pathway

Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality among the world, while the advance of TBI management is rather limited in recent years. The deregulation of microRNAs (miRNAs) has been widely reported in TBI …

08.05.2020 | Original Paper

Downregulation of Microrna-421 Relieves Cerebral Ischemia/Reperfusion Injuries: Involvement of Anti-apoptotic and Antioxidant Activities

Reperfusion after cerebral ischemia causes additional ischemic injuries due to sudden recovery of blood supply. It usually produces excessive reactive species, mitochondrial dysfunction, oxidative stress, and cell apoptosis. Our study is designed …

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NeuroMolecular Medicine presents cutting-edge research articles and critical reviews on the molecular and biochemical basis of neurological disorders. Coverage ranges from genetic analyses of human populations to animal and cell culture models of neurological disorders, and includes findings concerning the identification of genetic aberrancies and their pathogenic mechanisms at the molecular and cellular levels. Coverage includes experimental analyses of molecular cascades involved in the development and adult plasticity of the nervous system, in neurological dysfunction, and in neuronal degeneration and repair. NeuroMolecular Medicine encompasses basic research in molecular genetics, signal transduction, plasticity, and cell death. The journal gives special attention to synthetic research and reviews that aim to bridge genetic aberrancies with cellular and molecular mechanisms of neurological pathogenesis.

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Neu in den Fachgebieten Neurologie und Psychiatrie