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Neuroinformatics

Erschienen in:

01.10.2015 | Original Article

Edge-Centered DTI Connectivity Analysis: Application to Schizophrenia

verfasst von: Edward H. Herskovits, L. Elliot Hong, Peter Kochunov, Hemalatha Sampath, Rong Chen

Erschienen in: Neuroinformatics | Ausgabe 4/2015

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Abstract

Diffusion tensor imaging (DTI) provides connectivity information that helps illuminate the processes underlying normal development as well as brain disorders such as autism and schizophrenia. Researchers have widely adopted graph representations to model DTI connectivity among brain structures; however, most measures of connectivity have been centered on nodes, rather than edges, in these graphs. We present an edge-based algorithm for assessing anatomic connectivity; this approach provides information about connections among brain structures, rather than information about structures themselves. This perspective allows us to formulate multivariate graph-based models of altered connectivity that distinguish among experimental groups. We demonstrate the utility of this approach by analyzing data from an ongoing study of schizophrenia.

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Titel: Edge-Centered DTI Connectivity Analysis: Application to Schizophrenia
verfasst von: Edward H. Herskovits
L. Elliot Hong
Peter Kochunov
Hemalatha Sampath
Rong Chen
Publikationsdatum: 01.10.2015
Verlag: Springer US
Erschienen in: Neuroinformatics / Ausgabe 4/2015
Print ISSN: 1539-2791
Elektronische ISSN: 1559-0089
DOI: https://doi.org/10.1007/s12021-015-9273-6

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