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Immunologic Research

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01.12.2011 | Current Immunology Research at Jefferson

Interleukin 10 in the tumor microenvironment: a target for anticancer immunotherapy

verfasst von: Takami Sato, Mizue Terai, Yutaka Tamura, Vitali Alexeev, Michael J. Mastrangelo, Senthamil R. Selvan

Erschienen in: Immunologic Research | Ausgabe 2-3/2011

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Abstract

IL-10 is an immunomodulatory cytokine that is frequently upregulated in various types of cancer. The biological role of IL-10 in cancer is quite complex; however, the presence of IL-10 in advanced metastases and the positive correlation between serum IL-10 levels and progression of disease indicates a critical role of IL-10 in the tumor microenvironment. IL-10 has been shown to directly affect the function of antigen-presenting cells by inhibiting the expression of MHC and costimulatory molecules, which in turn induces immune suppression or tolerance. Additionally, IL-10 downregulates the expression of Th1 cytokines and induces T-regulatory responses. Taken together, a combination of IL-10 antagonism and immunostimulatory treatments such as cancer vaccines, Toll-like receptor agonists, Th1 cytokines, and chemokines would be a logical approach to enhance an antitumor immune response.

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Titel: Interleukin 10 in the tumor microenvironment: a target for anticancer immunotherapy
verfasst von: Takami Sato
Mizue Terai
Yutaka Tamura
Vitali Alexeev
Michael J. Mastrangelo
Senthamil R. Selvan
Publikationsdatum: 01.12.2011
Verlag: Humana Press Inc
Erschienen in: Immunologic Research / Ausgabe 2-3/2011
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-011-8262-6

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16.04.2024 | HNO-Chirurgie | Nachrichten

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Springer Medizin

Interleukin 10 in the tumor microenvironment: a target for anticancer immunotherapy

Abstract

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Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

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Springer Medizin

Abstract

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Neu im Fachgebiet HNO

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Update HNO