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Erschienen in: Immunologic Research 2-3/2014

01.12.2014 | FRONTIERS IN AUTOIMMUNITY

Autoimmune thyroid disease and rheumatoid arthritis: relationship and the role of genetics

verfasst von: Ivica Lazúrová, Ivana Jochmanová, Karim Benhatchi, Štefan Sotak

Erschienen in: Immunologic Research | Ausgabe 2-3/2014

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Abstract

Autoimmune thyroid disease (AITD), known as the most common organ-specific autoimmune disorder, is frequently accompanied by other organ and non-organ-specific autoimmune diseases, including rheumatoid arthritis (RA). Although the exact pathogenic mechanisms of the coexistence of autoimmune disorders are still not completely defined, genetics, immune defects, hormones and environmental factors may play key roles in polyautoimmunity. In this review, the prevalence of AITD and antithyroid autoantibodies in RA patients and rheumatic manifestations in association with thyroid autoimmunity are discussed. Finally, we review the role of genetics in the association of both AITD and RA, especially CTLA-4 and PTPN22 polymorphisms.
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Metadaten
Titel
Autoimmune thyroid disease and rheumatoid arthritis: relationship and the role of genetics
verfasst von
Ivica Lazúrová
Ivana Jochmanová
Karim Benhatchi
Štefan Sotak
Publikationsdatum
01.12.2014
Verlag
Springer US
Erschienen in
Immunologic Research / Ausgabe 2-3/2014
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-014-8598-9

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