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Erschienen in: Medical Oncology 10/2017

01.10.2017 | Review Article

Genetic susceptibility in childhood acute lymphoblastic leukemia

verfasst von: Angela Gutierrez-Camino, Idoia Martin-Guerrero, Africa García-Orad

Erschienen in: Medical Oncology | Ausgabe 10/2017

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Abstract

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and a leading cause of death due to disease in children. The genetic basis of ALL susceptibility has been supported by its association with certain congenital disorders and, more recently, by several genome-wide association studies (GWAS). These GWAS identified common variants in ARID5B, IKZF1, CEBPE, CDKN2A, PIP4K2A, LHPP and ELK3 influencing ALL risk. However, the risk variants of these SNPs were not validated in all populations, suggesting that some of the loci could be population specific. On the other hand, the currently identified risk SNPs in these genes only account for 19% of the additive heritable risk. This estimation indicates that additional susceptibility variants could be discovered. In this review, we will provide an overview of the most important findings carried out in genetic susceptibility of childhood ALL in all GWAS and subsequent studies and we will also point to future directions that could be explored in the near future.
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Metadaten
Titel
Genetic susceptibility in childhood acute lymphoblastic leukemia
verfasst von
Angela Gutierrez-Camino
Idoia Martin-Guerrero
Africa García-Orad
Publikationsdatum
01.10.2017
Verlag
Springer US
Erschienen in
Medical Oncology / Ausgabe 10/2017
Print ISSN: 1357-0560
Elektronische ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-017-1038-7

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