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Clinical and Translational Oncology
Erschienen in: Clinical and Translational Oncology 9/2017

09.03.2017 | Review Article

The role and clinical implications of the endosteal niche and osteoblasts in regulating leukemia

verfasst von: S. Azizidoost, V. Vijay, C. R. Cogle, E. Khodadi, N. Saki

Erschienen in: Clinical and Translational Oncology | Ausgabe 9/2017

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Abstract

Osteoblasts are one among the critical components of the endosteal bone marrow (BM) niche. In addition to hematopoietic stem cell fate, their role in leukemogenesis as well as metastasis of a variety of cancers has been demonstrated in various studies. In this regard, endosteal niche can have a dual role as an initiator and protective role against leukemia. Knowledge of growth factors, chemokines and cytokines secreted by osteoblasts as well as their interaction with signaling pathways inform our understanding of the development, prognosis, recurrence and treatment of malignant BM diseases. Clinical progress in targeting the endosteal niche is also discussed.
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Metadaten
Titel
The role and clinical implications of the endosteal niche and osteoblasts in regulating leukemia
verfasst von
S. Azizidoost
V. Vijay
C. R. Cogle
E. Khodadi
N. Saki
Publikationsdatum
09.03.2017
Verlag
Springer International Publishing
Erschienen in
Clinical and Translational Oncology / Ausgabe 9/2017
Print ISSN: 1699-048X
Elektronische ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-017-1642-1

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