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Erschienen in: Neuroethics 3/2013

01.12.2013 | Original Paper

Bonding Brains to Machines: Ethical Implications of Electroceuticals for the Human Brain

verfasst von: Jens Clausen

Erschienen in: Neuroethics | Ausgabe 3/2013

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Abstract

Novel neurotechnologies like deep brain stimulation and brain-computer interfaces promise clinical benefits for severely suffering patients. Nevertheless, such electroceuticals raise several ethical issues on different levels: while on the level of clinical neuroethics issues with direct relevance for diagnosis and treatment have to be discussed, on the level of research neuroethics questions regarding research and development of these technological devices like investigating new targets and different diseases as well as thorough inclusion criteria are dealt with. On the level of theoretical neuroethics more general questions are examined including anthropological considerations on “normal” human functioning as well as implications on personality, personal identity and authenticity. This paper presents a brief review on ethical issues of deep brain stimulation and brain computer interfacing and simultaneously introduces to this themed issue with thirteen contributions dealing from different perspectives with ethical implications of electroceuticals for the human brain.
Literatur
1.
2.
Zurück zum Zitat Deuschl, G., C. Schade-Brittinger, P. Krack, J. Volkmann, H. Schafer, K. Bötzel, C. Daniels, et al. 2006. A randomized trial of deep-brain stimulation for Parkinson’s disease. The New England Journal of Medicine 355(9): 896–908.CrossRef Deuschl, G., C. Schade-Brittinger, P. Krack, J. Volkmann, H. Schafer, K. Bötzel, C. Daniels, et al. 2006. A randomized trial of deep-brain stimulation for Parkinson’s disease. The New England Journal of Medicine 355(9): 896–908.CrossRef
3.
Zurück zum Zitat Deuschl, G., J. Raethjen, H. Hellriegel, and R. Elble. 2011. Treatment of patients with essential tremor. Lancet Neurology 10(2): 148–161.CrossRef Deuschl, G., J. Raethjen, H. Hellriegel, and R. Elble. 2011. Treatment of patients with essential tremor. Lancet Neurology 10(2): 148–161.CrossRef
4.
Zurück zum Zitat Mehrkens, J.H., K. Botzel, U. Steude, K. Zeitler, A. Schnitzler, V. Sturm, and J. Voges. 2009. Long-term efficacy and safety of chronic globus pallidus internus stimulation in different types of primary dystonia. Stereotactic and Functional Neurosurgery 87(1): 8–17.CrossRef Mehrkens, J.H., K. Botzel, U. Steude, K. Zeitler, A. Schnitzler, V. Sturm, and J. Voges. 2009. Long-term efficacy and safety of chronic globus pallidus internus stimulation in different types of primary dystonia. Stereotactic and Functional Neurosurgery 87(1): 8–17.CrossRef
5.
Zurück zum Zitat Schuepbach, W.M., J. Rau, K. Knudsen, J. Volkmann, P. Krack, L. Timmermann, T.D. Halbig, et al. 2013. Neurostimulation for Parkinson’s disease with early motor complications. The New England Journal of Medicine 368(7): 610–622. doi:10.1056/NEJMoa1205158.CrossRef Schuepbach, W.M., J. Rau, K. Knudsen, J. Volkmann, P. Krack, L. Timmermann, T.D. Halbig, et al. 2013. Neurostimulation for Parkinson’s disease with early motor complications. The New England Journal of Medicine 368(7): 610–622. doi:10.​1056/​NEJMoa1205158.CrossRef
6.
Zurück zum Zitat Andrade, P., L.H. Noblesse, Y. Temel, L. Ackermans, L.W. Lim, H.W. Steinbusch, and V. Visser-Vandewalle. 2010. Neurostimulatory and ablative treatment options in major depressive disorder: a systematic review. Acta Neurochirurgica 152(4): 565–577.CrossRef Andrade, P., L.H. Noblesse, Y. Temel, L. Ackermans, L.W. Lim, H.W. Steinbusch, and V. Visser-Vandewalle. 2010. Neurostimulatory and ablative treatment options in major depressive disorder: a systematic review. Acta Neurochirurgica 152(4): 565–577.CrossRef
7.
Zurück zum Zitat Greenberg, B.D., S.L. Rauch, and S.N. Haber. 2010. Invasive circuitry-based neurotherapeutics: stereotactic ablation and deep brain stimulation for OCD. Neuropsychopharmacology 35(1): 317–336.CrossRef Greenberg, B.D., S.L. Rauch, and S.N. Haber. 2010. Invasive circuitry-based neurotherapeutics: stereotactic ablation and deep brain stimulation for OCD. Neuropsychopharmacology 35(1): 317–336.CrossRef
8.
Zurück zum Zitat Laxton, A.W., D.F. Tang-Wai, M.P. McAndrews, D. Zumsteg, R. Wennberg, R. Keren, J. Wherrett, et al. 2010. A phase I trial of deep brain stimulation of memory circuits in Alzheimer’s disease. Annals of Neurology 68(4): 521–534.CrossRef Laxton, A.W., D.F. Tang-Wai, M.P. McAndrews, D. Zumsteg, R. Wennberg, R. Keren, J. Wherrett, et al. 2010. A phase I trial of deep brain stimulation of memory circuits in Alzheimer’s disease. Annals of Neurology 68(4): 521–534.CrossRef
9.
Zurück zum Zitat Hamani, C., M.P. McAndrews, M. Cohn, M. Oh, D. Zumsteg, C.M. Shapiro, R.A. Wennberg, and A.M. Lozano. 2008. Memory enhancement induced by hypothalamic/fornix deep brain stimulation. Annals of Neurology 63(1): 119–123.CrossRef Hamani, C., M.P. McAndrews, M. Cohn, M. Oh, D. Zumsteg, C.M. Shapiro, R.A. Wennberg, and A.M. Lozano. 2008. Memory enhancement induced by hypothalamic/fornix deep brain stimulation. Annals of Neurology 63(1): 119–123.CrossRef
10.
Zurück zum Zitat Schiff, N.D., J.T. Giacino, K. Kalmar, J.D. Victor, K. Baker, M. Gerber, B. Fritz, et al. 2007. Behavioural improvements with thalamic stimulation after severe traumatic brain injury. Nature 448(7153): 600–603.CrossRef Schiff, N.D., J.T. Giacino, K. Kalmar, J.D. Victor, K. Baker, M. Gerber, B. Fritz, et al. 2007. Behavioural improvements with thalamic stimulation after severe traumatic brain injury. Nature 448(7153): 600–603.CrossRef
11.
Zurück zum Zitat Müller, U.J., V. Sturm, J. Voges, H.J. Heinze, I. Galazky, M. Heldmann, H. Scheich, and B. Bogerts. 2009. Successful treatment of chronic resistant alcoholism by deep brain stimulation of nucleus accumbens: first experience with three cases. Pharmacopsychiatry 42(6): 288–291.CrossRef Müller, U.J., V. Sturm, J. Voges, H.J. Heinze, I. Galazky, M. Heldmann, H. Scheich, and B. Bogerts. 2009. Successful treatment of chronic resistant alcoholism by deep brain stimulation of nucleus accumbens: first experience with three cases. Pharmacopsychiatry 42(6): 288–291.CrossRef
12.
Zurück zum Zitat Bell, E., G. Mathieu, and E. Racine. 2009. Preparing the ethical future of deep brain stimulation. Surgical Neurology 72(6): 577–586. discussion 586.CrossRef Bell, E., G. Mathieu, and E. Racine. 2009. Preparing the ethical future of deep brain stimulation. Surgical Neurology 72(6): 577–586. discussion 586.CrossRef
13.
Zurück zum Zitat Clausen, J. 2009. Man, machine and in between. Nature 457(7233): 1080–1081.CrossRef Clausen, J. 2009. Man, machine and in between. Nature 457(7233): 1080–1081.CrossRef
14.
Zurück zum Zitat Clausen, J. 2010. Ethical brain stimulation – neuroethics of deep brain stimulation in research and clinical practice. European Journal of Neuroscience 32(7): 1152–1162.CrossRef Clausen, J. 2010. Ethical brain stimulation – neuroethics of deep brain stimulation in research and clinical practice. European Journal of Neuroscience 32(7): 1152–1162.CrossRef
16.
Zurück zum Zitat Schermer, M. 2011. Ethical issues in deep brain stimulation. Frontiers in Integrative Neuroscience 5: 17.CrossRef Schermer, M. 2011. Ethical issues in deep brain stimulation. Frontiers in Integrative Neuroscience 5: 17.CrossRef
17.
Zurück zum Zitat Synofzik, M., and T.E. Schlaepfer. 2011. Electrodes in the brain–ethical criteria for research and treatment with deep brain stimulation for neuropsychiatric disorders. Brain Stimulation 4(1): 7–16.CrossRef Synofzik, M., and T.E. Schlaepfer. 2011. Electrodes in the brain–ethical criteria for research and treatment with deep brain stimulation for neuropsychiatric disorders. Brain Stimulation 4(1): 7–16.CrossRef
18.
Zurück zum Zitat Synofzik, M., and T.E. Schlaepfer. 2008. Stimulating personality: ethical criteria for deep brain stimulation in psychiatric patients and for enhancement purposes. Biotechnology Journal 3(12): 1511–1520.CrossRef Synofzik, M., and T.E. Schlaepfer. 2008. Stimulating personality: ethical criteria for deep brain stimulation in psychiatric patients and for enhancement purposes. Biotechnology Journal 3(12): 1511–1520.CrossRef
19.
Zurück zum Zitat Schermer, Maartje. 2013. Health, happieness and human enhancement - dealing with unexpected effects of deep brain stimulation. Neuroethics 6 (3). doi:10.1007/s12152-011-9097-5. Schermer, Maartje. 2013. Health, happieness and human enhancement - dealing with unexpected effects of deep brain stimulation. Neuroethics 6 (3). doi:10.​1007/​s12152-011-9097-5.
20.
Zurück zum Zitat Focquaert, F. 2013. Deep brain stimulation in children: parental authority versus shared decision-making. Neuroethics 6(3). Focquaert, F. 2013. Deep brain stimulation in children: parental authority versus shared decision-making. Neuroethics 6(3).
21.
Zurück zum Zitat Johansson, Veronica, Martin Garwicz, Martin Kanje, Helena Röcklingsberg, Jens Schouenborg, Anders Tingström, and Ulf Görman. 2013. Byond blind optimism and unfounded fears: deep brain stimulation for treatment resistant depression. Neuroethics 6 (3). doi:10.1007/s12152-011-9112-x. Johansson, Veronica, Martin Garwicz, Martin Kanje, Helena Röcklingsberg, Jens Schouenborg, Anders Tingström, and Ulf Görman. 2013. Byond blind optimism and unfounded fears: deep brain stimulation for treatment resistant depression. Neuroethics 6 (3). doi:10.​1007/​s12152-011-9112-x.
22.
Zurück zum Zitat Kraemer, Felicitas. 2013. Me, myself and my brain implant: deep brain stimulation raises questions of personal authenticity and alienation. Neuroethics 6 (3). doi: 10.107/s12152-011-9115-7. Kraemer, Felicitas. 2013. Me, myself and my brain implant: deep brain stimulation raises questions of personal authenticity and alienation. Neuroethics 6 (3). doi: 10.​107/​s12152-011-9115-7.
23.
Zurück zum Zitat Schuepbach, M., M. Gargiulo, M.L. Welter, C. Luc Mallet, J.L. Behar, D. Houeto, D. Maltete, V. Mesnage, and Y. Agid. 2006. Neurosurgery in Parkinson disease: a distressed mind in a repaired body? Neurology 66(12): 1811–1816.CrossRef Schuepbach, M., M. Gargiulo, M.L. Welter, C. Luc Mallet, J.L. Behar, D. Houeto, D. Maltete, V. Mesnage, and Y. Agid. 2006. Neurosurgery in Parkinson disease: a distressed mind in a repaired body? Neurology 66(12): 1811–1816.CrossRef
24.
25.
Zurück zum Zitat Baylis, F. 2013. “I am Who I Am”: on the perceived threats to personal identity from deep brain stimulation. Neuroethics 6(3). Baylis, F. 2013. “I am Who I Am”: on the perceived threats to personal identity from deep brain stimulation. Neuroethics 6(3).
26.
Zurück zum Zitat Klaming, L., and P. Haselager. 2013. Did my brain implant make me do it? questions raised by DBS regarding psychological continuity, responsibility for action and mental competence. Neuroethics 6(3). doi:10.1007/s12152-010-9093-1. Klaming, L., and P. Haselager. 2013. Did my brain implant make me do it? questions raised by DBS regarding psychological continuity, responsibility for action and mental competence. Neuroethics 6(3). doi:10.​1007/​s12152-010-9093-1.
27.
Zurück zum Zitat van Gerven, M., J. Farquhar, R. Schaefer, R. Vlek, J. Geuze, A. Nijholt, Nick Ramsey, et al. 2009. The brain-computer interface cycle. Journal of Neural Engineering 6(4): 041001.CrossRef van Gerven, M., J. Farquhar, R. Schaefer, R. Vlek, J. Geuze, A. Nijholt, Nick Ramsey, et al. 2009. The brain-computer interface cycle. Journal of Neural Engineering 6(4): 041001.CrossRef
28.
Zurück zum Zitat Birbaumer, N., and L.G. Cohen. 2007. Brain-computer interfaces: communication and restoration of movement in paralysis. The Journal of Physiology 579(3): 621–636.CrossRef Birbaumer, N., and L.G. Cohen. 2007. Brain-computer interfaces: communication and restoration of movement in paralysis. The Journal of Physiology 579(3): 621–636.CrossRef
29.
Zurück zum Zitat Collinger, J.L., B. Wodlinger, J.E. Downey, W. Wang, E.C. Tyler-Kabara, D.J. Weber, A.J. McMorland, M. Velliste, M.L. Boninger, and A.B. Schwartz. 2013. High-performance neuroprosthetic control by an individual with tetraplegia. Lancet 381(9866): 557–564. doi:10.1016/S0140-6736(12)61816-9.CrossRef Collinger, J.L., B. Wodlinger, J.E. Downey, W. Wang, E.C. Tyler-Kabara, D.J. Weber, A.J. McMorland, M. Velliste, M.L. Boninger, and A.B. Schwartz. 2013. High-performance neuroprosthetic control by an individual with tetraplegia. Lancet 381(9866): 557–564. doi:10.​1016/​S0140-6736(12)61816-9.CrossRef
30.
Zurück zum Zitat Arnold, L.E., N. Lofthouse, S. Hersch, X. Pan, E. Hurt, B. Bates, K. Kassouf, S. Moone, and C. Grantier. 2013. EEG Neurofeedback for ADHD: Double-Blind Sham-Controlled Randomized Pilot Feasibility Trial. J Atten Disord 17(5): 410–419. doi:10.1177/1087054712446173.CrossRef Arnold, L.E., N. Lofthouse, S. Hersch, X. Pan, E. Hurt, B. Bates, K. Kassouf, S. Moone, and C. Grantier. 2013. EEG Neurofeedback for ADHD: Double-Blind Sham-Controlled Randomized Pilot Feasibility Trial. J Atten Disord 17(5): 410–419. doi:10.​1177/​1087054712446173​.CrossRef
31.
Zurück zum Zitat Jotterand, Fabrice, and James Giordano. 2014 (in press). Real-time Functional Magnetic Resonance Imaging (rtfMRI)-Brain Computer Interfacing in the Assessment and Treatment of Psychopathy : Potential and Challenges. In Handbook of Neuroethics, eds. Jens Clausen, and Neil Levy. Berlin: Springer. Jotterand, Fabrice, and James Giordano. 2014 (in press). Real-time Functional Magnetic Resonance Imaging (rtfMRI)-Brain Computer Interfacing in the Assessment and Treatment of Psychopathy : Potential and Challenges. In Handbook of Neuroethics, eds. Jens Clausen, and Neil Levy. Berlin: Springer.
32.
Zurück zum Zitat Clausen, J. 2008. Moving minds: ethical aspects of neural motor prostheses. Biotechnology Journal 3(12): 1493–1501.CrossRef Clausen, J. 2008. Moving minds: ethical aspects of neural motor prostheses. Biotechnology Journal 3(12): 1493–1501.CrossRef
33.
Zurück zum Zitat O’Brolcháin, Fiachra, and Bert Gordijn. 2014 in press. BCIs for enhancement purposes: ethical implications. In Handbook of Neuroethics, eds. Jens Clausen, and Neil Levy. Berlin: Springer. O’Brolcháin, Fiachra, and Bert Gordijn. 2014 in press. BCIs for enhancement purposes: ethical implications. In Handbook of Neuroethics, eds. Jens Clausen, and Neil Levy. Berlin: Springer.
34.
Zurück zum Zitat Tamburrini, G. 2009. Brain to computer communication: ethical perspectives on interaction models. Neuroethics 2(3): 137–149.CrossRef Tamburrini, G. 2009. Brain to computer communication: ethical perspectives on interaction models. Neuroethics 2(3): 137–149.CrossRef
35.
Zurück zum Zitat Matthias, A. 2004. The responsibility gap: ascribing responsibility for the actions of learning automata. Ethics and Information Technology 6(3): 175–183.CrossRef Matthias, A. 2004. The responsibility gap: ascribing responsibility for the actions of learning automata. Ethics and Information Technology 6(3): 175–183.CrossRef
36.
Zurück zum Zitat Holm, Søren, and Teck Chuan Voo. 2010. Brain-Machine Interfaces and Personal Responsibility for Action - Maybe Not As Complicated After All. Studies in Ethics, Law, and Technology 4 (3):Article 7. Holm, Søren, and Teck Chuan Voo. 2010. Brain-Machine Interfaces and Personal Responsibility for Action - Maybe Not As Complicated After All. Studies in Ethics, Law, and Technology 4 (3):Article 7.
37.
Zurück zum Zitat Phillips, L. H. 2006. Communicating with the ‘locked-in’ patient: because you can so it, should you? Neurology Vol. 67 (3): 380-381 Phillips, L. H. 2006. Communicating with the ‘locked-in’ patient: because you can so it, should you? Neurology Vol. 67 (3): 380-381
38.
Zurück zum Zitat Bruno, M.-A., L.J. Bernheim, D. Ledoux, F. Pellas, A. Demertzi, and S. Laureys. 2011. A survey on self-assessed well-being in a cohort of chronic locked-in syndrome patients: happy majority, miserable minority. BMJ Open. doi:10.1136/bmjopen-2010-000039. Bruno, M.-A., L.J. Bernheim, D. Ledoux, F. Pellas, A. Demertzi, and S. Laureys. 2011. A survey on self-assessed well-being in a cohort of chronic locked-in syndrome patients: happy majority, miserable minority. BMJ Open. doi:10.​1136/​bmjopen-2010-000039.
39.
Zurück zum Zitat Vlek, R.J., D. Steines, D. Szibbo, A. Kubler, M.J. Schneider, P. Haselager, and F. Nijboer. 2012. Ethical issues in brain-computer interface research, development, and dissemination. Journal of Neurologic Physical Therapy 36(2): 94–99. doi:10.1097/NPT.0b013e31825064cc.CrossRef Vlek, R.J., D. Steines, D. Szibbo, A. Kubler, M.J. Schneider, P. Haselager, and F. Nijboer. 2012. Ethical issues in brain-computer interface research, development, and dissemination. Journal of Neurologic Physical Therapy 36(2): 94–99. doi:10.​1097/​NPT.​0b013e31825064cc​.CrossRef
40.
Zurück zum Zitat Neijboer, F., J. Clausen, B.Z. Allison, and P. Haselager. 2013. The asilomar survey: stakeholders’ opinions on ethical issues related to brain-computer interfacing. Neuroethics 6(3). doi:10.1007/s12152-011-9132-6. Neijboer, F., J. Clausen, B.Z. Allison, and P. Haselager. 2013. The asilomar survey: stakeholders’ opinions on ethical issues related to brain-computer interfacing. Neuroethics 6(3). doi:10.​1007/​s12152-011-9132-6.
41.
Zurück zum Zitat Kyselo, M. 2013. Locked-in Syndrome, and BCI – Towards an enactive approach of the self. Neuroethics 6(3). Kyselo, M. 2013. Locked-in Syndrome, and BCI – Towards an enactive approach of the self. Neuroethics 6(3).
42.
Zurück zum Zitat Fenton, A., and S. Alpert. 2008. Extending our view on using BCIs for locked-in syndrome. Neuroethics 1: 119–132.CrossRef Fenton, A., and S. Alpert. 2008. Extending our view on using BCIs for locked-in syndrome. Neuroethics 1: 119–132.CrossRef
43.
Zurück zum Zitat Buller, T. 2013. Neurotechnology, Invasiveness and the extended mind. Neuroethics 6(3). Buller, T. 2013. Neurotechnology, Invasiveness and the extended mind. Neuroethics 6(3).
44.
Zurück zum Zitat Wolbring, G. 2013. Hearing beyond the normal enabled by therapeutic devices: the role of the recipient and the hearing profession. Neuroethics 6(3). doi:10.1007/s12152-011-9120-x. Wolbring, G. 2013. Hearing beyond the normal enabled by therapeutic devices: the role of the recipient and the hearing profession. Neuroethics 6(3). doi:10.​1007/​s12152-011-9120-x.
45.
Zurück zum Zitat Jebari, Karim. 2013. Brain Machine Interfaces and Human Enhancement - An Ethical Review Neuroethics 6 (3). Jebari, Karim. 2013. Brain Machine Interfaces and Human Enhancement - An Ethical Review Neuroethics 6 (3).
Metadaten
Titel
Bonding Brains to Machines: Ethical Implications of Electroceuticals for the Human Brain
verfasst von
Jens Clausen
Publikationsdatum
01.12.2013
Verlag
Springer Netherlands
Erschienen in
Neuroethics / Ausgabe 3/2013
Print ISSN: 1874-5490
Elektronische ISSN: 1874-5504
DOI
https://doi.org/10.1007/s12152-013-9186-8

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