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International Journal of Hematology
Erschienen in: International Journal of Hematology 2/2019

24.04.2019 | Progress in Hematology

Clinical update on hypomethylating agents

verfasst von: Matthieu Duchmann, Raphael Itzykson

Erschienen in: International Journal of Hematology | Ausgabe 2/2019

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Abstract

Hypomethylating agents (HMAs), azacitidine and decitabine, are standards of care in higher-risk myelodysplastic syndromes and in acute myeloid leukemia patients ineligible for intensive therapy. Over the last 10 years, research efforts have sought to better understand their mechanism of action, both at the molecular and cellular level. These efforts have yet to robustly identify biomarkers for these agents. The clinical activity of HMAs in myeloid neoplasms has been firmly established now but still remains of limited magnitude. Besides optimized use at different stages of the disease, most of the expected clinical progress with HMAs will come from the development of second-generation compounds orally available and/or with improved pharmacokinetics, and from the search, so far mostly empirical, of HMA-based synergistic drug combinations.
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Metadaten
Titel
Clinical update on hypomethylating agents
verfasst von
Matthieu Duchmann
Raphael Itzykson
Publikationsdatum
24.04.2019
Verlag
Springer Japan
Erschienen in
International Journal of Hematology / Ausgabe 2/2019
Print ISSN: 0925-5710
Elektronische ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-019-02651-9

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