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ADHD Attention Deficit and Hyperactivity Disorders

Erschienen in:

01.06.2012 | Review Article

Cortisol responses in children and adults with attention deficit hyperactivity disorder (ADHD): a possible marker of inhibition deficits

verfasst von: M. Corominas, J. A. Ramos-Quiroga, M. Ferrer, N. Sáez-Francàs, G. Palomar, R. Bosch, M. Casas

Erschienen in: ADHD Attention Deficit and Hyperactivity Disorders | Ausgabe 2/2012

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Abstract

Attention deficit hyperactivity disorder (ADHD) is a heterogeneous disease whose neurobiological background is not completely understood. It has been proposed that deficits of the inhibitory function with an underactive behavioral inhibition system (BIS) may be in the core of ADHD. In this regard, this review summarizes all studies that examine the involvement of cortisol in ADHD. Differences in cortisol responses from different ADHD subtypes, hyperactive/impulsive, inattentive, and combined, are analyzed. In addition, we examine the role of comorbidities as confounding factors in the study of cortisol in ADHD, including comorbid disruptive behavioral disorder (DBD), as well as anxiety and depressive disorders. Because ADHD is a neurodevelopmental condition and approximately half of the children enter adulthood with the disorder, we review cortisol studies in adults and children separately. Two diverse patterns of cortisol have been reported both in children and adults with ADHD. Blunted cortisol responses to stress are associated with comorbid DBD, whereas high cortisol responses are associated to comorbid anxiety disorders. Nevertheless, the inhibitory deficits in ADHD do not appear to be related directly to cortisol deficits in either children or adults. This review increases our understanding of the heterogeneity of ADHD and could help in determining new strategies for the treatment of these patients. Future studies including gender and a more systematic methodology to study the cortisol response are needed.

Achenbach TM, Edelbrock C (1983) Manual for the child behavior checklist and revised child behavior profile. University of Vermont, Burlington

Adam EK, Kumari M (2009) Assessing salivary cortisol in large-scale, epidemiological research. Psychoneuroendocrinology 34:1423–1436PubMedCrossRef

Adler LA, Kunz M, Chua HC, Rotrosen J, Resnick SG (2004) Attention-deficit/hyperactivity disorder in adult patients with posttraumatic stress disorder (PTSD): is ADHD a vulnerability factor? J Atten Disord 8:11–16PubMedCrossRef

Alink L, van IJzendoorn M, Bakermans-Kranenburg M, Mesman J, Juffer F, Koot H (2008) Cortisol and externalizing behavior in children and adolescents: Mixed meta-analytic evidence for the inverse relation of basal cortisol and cortisol reactivity with externalizing behavior. Dev Psychobiol 50:427–450PubMedCrossRef

Almela M, Hidalgo V, Villada C, Espín L, Gómez-Amor J, Salvador A (2011) The impact of cortisol reactivity to acute stress on memory: sex differences in middle-aged people. Stress 14:117–127PubMed

Arnsten A (2009) The emerging neurobiology of attention deficit hyperactivity disorder: the key role of the prefrontal association cortex. J Pediatr 154:e89–e99CrossRef

Barkley RA (1997) Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychol Bull 121:65–94PubMedCrossRef

Barkley RA (2002) Major life activity and health outcomes associated with attention-deficit/hyperactivity disorder. J Clin Psychiatry 12:10–15

Biederman J, Faraone SV (2005) Attention-deficit hyperactivity disorder. The Lancet 366:237–248CrossRef

Biederman J, Rosenbaum J, Bolduc-Murphy E, Faraone S, Chaloff J, Hirshfeld D, Kagan J (1993) A 3-year follow-up of children with and without behavioral inhibition. J Am Acad Child Adolesc Psychiatry 32:814–821PubMedCrossRef

Blair C, Peters R, Granger D (2004) Physiological and neuropsychological correlates of approach/withdrawal tendencies in preschool: further examination of the behavioral inhibition system/behavioral activation system scales for young children. Dev Psychobiol 45:113–124PubMedCrossRef

Blomqvist M, Holmberg K, Lindblad F, Fernell E, Ek U, Dahllöf G (2007) Salivary cortisol levels and dental anxiety in children with attention deficit hyperactivity disorder. Eur J Oral Sci 115:1–6PubMedCrossRef

Buitelaar JK, Kooij JJS, Ramos-Quiroga JA, Dejonckheere J, Casas M, van Oene JC, Schäuble B, Trott G-E (2011) Predictors of treatment outcome in adults with ADHD treated with OROS^® methylphenidate. Prog Neuropsychopharmacol Biol Psychiatry 35:554–560PubMedCrossRef

Burt S, Krueger R, McGue M, Iacono W (2003) Parent-child conflict and the comorbidity among childhood externalizing disorders. Arch Gen Psychiatry 60:505–513PubMedCrossRef

Christiansen H, Oades R, Psychogiou L, Hauffa B, Sonuga-Barke E (2010) Does the cortisol response to stress mediate the link between expressed emotion and oppositional behavior in Attention-Deficit/Hyperactivity-Disorder (ADHD)? Behav Brain Funct 6:45PubMedCrossRef

Connor DF, Chartier KG, Preen EC, Kaplan RF (2010) Impulsive aggression in attention-deficit/hyperactivity disorder: symptom severity, co-morbidity, and attention-deficit/hyperactivity disorder subtype. J Child Adolesc Psychopharmacol 20:119–126PubMedCrossRef

Cortese S (2010) Review: ADHD impairs quality of life, but children and young people with ADHD perceive less impairment than parents. Evid Based Ment Health 13:76PubMedCrossRef

Crockett MJ, Clark L, Robbins TW (2009) Reconciling the role of serotonin in behavioral inhibition and aversion: acute tryptophan depletion abolishes punishment-induced inhibition in humans. J Neurosci 29:11993–11999PubMedCrossRef

Cuffe S, Moore C, McKeown R (2005) Prevalence and correlates of ADHD symptoms in the National Health Interview Survey. J Atten Disord 9:392–401PubMedCrossRef

Dolan M (2008) Neurobiological disturbances in callous-unemotional youths. Am J Psychiatry 165:668–670PubMedCrossRef

Dorn LD, Kolko DJ, Susman EJ, Huang B, Stein H, Music E, Bukstein OG (2009) Salivary gonadal and adrenal hormone differences in boys and girls with and without disruptive behavior disorders: contextual variants. Biol Psychol 81:31–39PubMedCrossRef

Essau CA, Sasagawa S, Frick PJ (2006) Callous-unemotional traits in a community sample of adolescents. Assessment 13:454–469PubMedCrossRef

Fairchild G, van Goozen S, Stollery S, Brown J, Gardiner J, Herbert J, Goodyer I (2008) Cortisol diurnal rhythm and stress reactivity in male adolescents with early-onset or adolescence-onset conduct disorder. Biol Psychiatry 64:599–606PubMedCrossRef

Faraone SV, Biederman J (2005) What is the prevalence of adult ADHD? Results of a population screen of 966 adults. J Atten Disord 9:384–391PubMedCrossRef

Faraone S, Perlis R, Doyle A, Smoller J, Goralnick J, Holmgren M, Sklar P (2005) Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry 57:1313–1323PubMedCrossRef

Franke B, Vasquez AA, Johansson S, Hoogman M, Romanos J, Boreatti-Hummer A, Heine M, Jacob CP, Lesch K-P, Casas M, Ribases M, Bosch R, Sanchez-Mora C, Gomez-Barros N, Fernandez-Castillo N, Bayes M, Halmoy A, Halleland H, Landaas ET, Fasmer OB, Knappskog PM, Heister AJGAM, Kiemeney LA, Kooij JJS, Boonstra AM, Kan CC, Asherson P, Faraone SV, Buitelaar JK, Haavik J, Cormand B, Ramos-Quiroga JA, Reif A (2009) Multicenter analysis of the SLC6A3/DAT1 VNTR haplotype in persistent ADHD suggests differential involvement of the gene in childhood and persistent ADHD. Neuropsychopharmacology 35:656–664PubMedCrossRef

Freitag CM, Hänig S, Palmason H, Meyer J, Wüst S, Seitz C (2009) Cortisol awakening response in healthy children and children with ADHD: impact of comorbid disorders and psychosocial risk factors. Psychoneuroendocrinology 34:1019–1028PubMedCrossRef

Gomez R, Corr P (2010) Attention-deficit/hyperactivity disorder symptoms: association with Gray’s and Tellegen’s models of personality. Personal Individ Differ 49:902–906CrossRef

Graetz B, Sawyer M, Hazell P, Arney F, Baghurst P (2001) Validity of DSM-IV ADHD subtypes in a nationally representative sample of Australian children and adolescents. J Am Acad Child Adolesc Psychiatry 40:1410–1417PubMedCrossRef

Gray JA (1987) The psychology of fear and stress. Cambridge University Press, New York

Greaves-Lord K, Ferdinand R, Oldehinkel A, Sondeijker F, Ormel J, Verhulst F (2007) Higher cortisol awakening response in young adolescents with persistent anxiety problems. Acta Psychiatr Scand 116:137–144PubMedCrossRef

Green J, Stanley C, Peters S (2007) Disorganized attachment representation and atypical parenting in young school age children with externalizing disorder. Attach Hum Dev 9:207–222PubMedCrossRef

Groman SM, James AS, Jentsch JD (2009) Poor response inhibition: at the nexus between substance abuse and attention deficit/hyperactivity disorder. Neurosci Biobehav Rev 33:690–698PubMedCrossRef

Hart EL, Lahey BB, Loeber R, Applegate B, Frick PJ (1995) Developmental change in attention-deficit hyperactivity disorder in boys: a four-year longitudinal study. J Abnorm Child Psychol 23:729–749PubMedCrossRef

Hastings P, Fortier I, Utendale W, Simard L, Robaey P (2009) Adrenocortical functioning in boys with attention-deficit/hyperactivity disorder: examining subtypes of ADHD and associated comorbid conditions. J Abnorm Child Psychol 37:565–578PubMedCrossRef

Herpertz SC, Mueller B, Qunaibi M, Lichterfeld C, Konrad K, Herpertz-Dahlmann B (2005) Response to emotional stimuli in boys with conduct disorder. Am J Psychiatry 162:1100–1107PubMedCrossRef

Hirvikoski T, Lindholm T, Nordenström A, Nordström A-L, Lajic S (2009) High self-perceived stress and many stressors, but normal diurnal cortisol rhythm, in adults with ADHD (attention-deficit/hyperactivity disorder). Horm Behav 55:418–424PubMedCrossRef

Hong HJ, Shin DW, Lee EH, Oh YH, Noh KS (2003) Hypothalamic-pituitary-adrenal reactivity in boys with attention deficit hyperactivity disorder. Yonsei Med J 44:608–614PubMed

Kane MJ, Engle RW (2002) The role of prefrontal cortex in working-memory capacity, executive attention, and general fluid intelligence: an individual-differences perspective. Psychon Bull Rev 9:637–671PubMedCrossRef

Kaneko M, Hoshino Y, Hashimoto S, Okano T, Kumashiro H (1993) Hypothalamic-pituitary-adrenal axis function in children with attention-deficit hyperactivity disorder. J Autism Dev Disord 23:59–65PubMedCrossRef

Kariyawasam SH, Zaw F, Handley S (2002) Reduced salivary cortisol in children with comorbid attention deficit hyperactivity disorder and oppositional defiant disorder. Neuro Endocrinol Lett 23:45–48PubMed

Kessler RC, Adler L, Barkley R, Biederman J, Conners CK, Demler O, Faraone SV, Greenhill LL, Howes MJ, Secnik K, Spencer T, Ustun TB, Walters EE, Zaslavsky AM (2006) The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication. Am J Psychiatry 163:716–723PubMedCrossRef

King J, Barkley R, Barrett S (1998) Attention-deficit hyperactivity disorder and the stress response. Biol Psychiatry 44:72–74PubMedCrossRef

Kirschbaum C, Hellhammer DH (1994) Salivary cortisol in psychoneuroendocrine research: recent developments and applications. Psychoneuroendocrinology 19:313–333PubMedCrossRef

Lackschewitz H, Hüther G, Kröner-Herwig B (2008) Physiological and psychological stress responses in adults with attention-deficit/hyperactivity disorder (ADHD). Psychoneuroendocrinology 33:612–624PubMedCrossRef

Lampe K, Konrad K, Kroeners S, Fast K, Kunert HJ, Herpertz SC (2007) Neuropsychological and behavioural disinhibition in adult ADHD compared to borderline personality disorder. Psychol Med 37:1717–1729PubMedCrossRef

Lee S, Shin D, Stein M (2010) Increased cortisol after stress is associated with variability in response time in ADHD children. Yonsei Med J 51:206–211PubMedCrossRef

Loney BR, Butler MA, Lima EN, Counts CA, Eckel LA (2006) The relation between salivary cortisol, callous-unemotional traits, and conduct problems in an adolescent non-referred sample. J Child Psychol Psychiatry 47:30–36PubMedCrossRef

Ma L, Chen Y-H, Chen H, Liu Y-Y, Wang Y-X (2011) The function of hypothalamus-pituitary-adrenal axis in children with ADHD. Brain Res 1368:159–162PubMedCrossRef

Maldonado E, Trianes M, Cortés A, Moreno E, Escobar M (2009) Cortisol response to a psychosocial stressor on children diagnosed with attention-deficit/hyperactivity disorder: differences between diagnostic subtypes. Span J Psychol 12:707–714PubMed

Mannie ZN, Harmer CJ, Cowen PJ (2007) Increased waking salivary cortisol levels in young people at familial risk of depression. Am J Psychiatry 164:617–621PubMedCrossRef

Marsh AA, Finger EC, Mitchell DGV, Reid ME, Sims C, Kosson DS, Towbin KE, Leibenluft E, Pine DS, Blair RJR (2008) Reduced Amygdala response to fearful expressions in children and adolescents with callous-unemotional traits and disruptive behavior disorders. Am J Psychiatry 165:712–720PubMedCrossRef

Mathews TA, Fedele DE, Coppelli FM, Avila AM, Murphy DL, Andrews AM (2004) Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression. J Neurosci Methods 140:169–181PubMedCrossRef

Mcburnett K, Lahey B, Frick P, Risch C, Loeber R, Hart E, Christ A, Hanson K (1991) Anxiety, inhibition, and conduct disorder in children: II. Relation to salivary cortisol. J Am Acad Child Adolesc Psychiatry 30:192–196PubMedCrossRef

Mick E, Faraone S, Biederman J (2004) Age-dependent expression of attention-deficit/hyperactivity disorder symptoms. Psychiatr Clin North Am 27:215–224PubMedCrossRef

Montañez S, Owens W, Gould G, Murphy D, Daws L (2003) Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout mice. J Neurochem 86:210–219PubMedCrossRef

Moore B (2002) Cortisol, stress and depression. Br J Psychiatry 181:348–353PubMedCrossRef

O’Hara R, Schroder CM, Mahadevan R, Schatzberg AF, Lindley S, Fox S, Weiner M, Kraemer HC, Noda A, Lin X, Gray HL, Hallmayer JF (2007) Serotonin transporter polymorphism, memory and hippocampal volume in the elderly: association and interaction with cortisol. Mol Psychiatry 12:544–555PubMedCrossRef

Pajer K, Gardner W, Rubin R, Perel J, Neal S (2001) Decreased cortisol levels in adolescent girls with conduct disorder. Arch Gen Psychiatry 58:297–302PubMedCrossRef

Pesonen A-K, Kajantie E, Heinonen K, Pyhälä R, Lahti J, Jones A, Matthews KA, Eriksson JG, Strandberg T, Räikkönen K (2012) Sex-specific associations between sleep problems and hypothalamic–pituitary–adrenocortical axis activity in children. Psychoneuroendocrinology 37:238–248PubMedCrossRef

Piwowarska J, Wrzosek M, Radziwoń-Zaleska M, Ryszewska-Pokraśniewicz B, Skalski M, Matsumoto H, Biernacka-Bazyluk A, Szelenberger W, Pachecka J (2009) Serum cortisol concentration in patients with major depression after treatment with clomipramine. Pharmacol Rep 2(61):604–611

Poustka L, Maras A, Hohm E, Fellinger J, Holtmann M, Banaschewski T, Lewicka S, Schmidt MH, Esser G, Laucht M (2010) Negative association between plasma cortisol levels and aggression in a high-risk community sample of adolescents. J Neural Transm 117:621–627PubMedCrossRef

Quay HC (1988) Theories of ADDH. J Am Acad Child Adolesc Psychiatry 27(2):262PubMedCrossRef

Quay HC (1997) Inhibition and attention deficit hyperactivity disorder. J Abnorm Child Psychol 25:7–13PubMedCrossRef

Ramos-Quiroga J, Ribasés-Haro M, Bosch-Munsó R, Cormand-Rifà B, Casas M (2007) Genetic advances in attention deficit hyperactivity disorder. Rev Neurol 44(Suppl 3):S51–S52PubMed

Randazzo W, Dockray S, Susman E (2008) The stress response in adolescents with inattentive type ADHD symptoms. Child Psychiatry Hum Dev 39:27–38PubMedCrossRef

Rasmussen P, Gillberg C (2000) Natural outcome of ADHD with developmental coordination disorder at age 22 years: a controlled, longitudinal, community-based study. J Am Acad Child Adolesc Psychiatry 39:1424–1431PubMedCrossRef

Ribases M, Ramos-Quiroga JA, Hervas A, Bosch R, Bielsa A, Gastaminza X, Artigas J, Rodriguez-Ben S, Estivill X, Casas M, Cormand B, Bayes M (2009) Exploration of 19 serotoninergic candidate genes in adults and children with attention-deficit/hyperactivity disorder identifies association for 5HT2A, DDC and MAOB. Mol Psychiatry 14:71–85PubMedCrossRef

Ribasés M, Hervás A, Ramos-Quiroga JA, Bosch R, Bielsa A, Gastaminza X, Fernández-Anguiano M, Nogueira M, Gómez-Barros N, Valero S, Gratacòs M, Estivill X, Casas M, Cormand B, Bayés M (2008) Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder. Biol Psychiatry 63:935–945PubMedCrossRef

Schommer NC, Hellhammer DH, Kirschbaum C (2003) Dissociation between reactivity of the hypothalamus-pituitary-adrenal axis and the sympathetic-adrenal-medullary system to repeated psychosocial stress. Psychosom Med 65:450–460PubMedCrossRef

Schulz P, Halperin M, Newcorn J, Sharma V, Gabriel S (1997) Plasma cortisol and aggression in boys with ADHD. J Am Acad Child Adolesc Psychiatry 36:605–609PubMedCrossRef

Shirtcliff EA, Granger DA, Booth A, Johnson D (2005) Low salivary cortisol levels and externalizing behavior problems in youth. Dev Psychopathol 17:167–184PubMedCrossRef

Snoek H, Van Goozen SHM, Matthys W, Buitelaar JK, Van Eengeland H (2004) Stress responsivity in children with externalizing behavior disorders. Dev Psychopathol 16:389–406PubMedCrossRef

Spangler G (1991) The emergence of adrenocortical circadian function in newborns and infants and its relationship to sleep, feeding and maternal adrenocortical activity. Early Hum Dev 25:197–208PubMedCrossRef

Stadler C, Zepf FD, Demisch L, Schmitt M, Landgraf M, Poustka F (2007) Influence of rapid tryptophan depletion on laboratory-provoked aggression in children with ADHD. Neuropsychobiology 56:104–110PubMedCrossRef

Stadler C, Kroeger A, Weyers P, Grasmann D, Horschinek M, Freitag C, Clement H-W (2011) Cortisol reactivity in boys with attention-deficit/hyperactivity disorder and disruptive behavior problems: the impact of callous unemotional traits. Psychiatry Res 187:204–209PubMedCrossRef

Tennes K, Kreye M, Avitable N, Wells R (1986) Behavioral correlates of excreted catecholamines and cortisol in second[hyphen (true graphic)]grade children. J Am Acad Child Psychiatry 25:764–770PubMedCrossRef

van West D, Claes S, Deboutte D (2009) Differences in hypothalamic-pituitary-adrenal axis functioning among children with ADHD predominantly inattentive and combined types. Eur Child Adolesc Psychiatry 18:543–553PubMedCrossRef

Vreeburg SA, Zitman FG, van Pelt J, DeRijk RH, Verhagen JCM, van Dyck R, Hoogendijk WJG, Smit JH, Penninx BWJH (2010) Salivary cortisol levels in persons with and without different anxiety disorders. Psychosom Med 72:340–347PubMedCrossRef

Wardenaar KJ, Vreeburg SA, van Veen T, Giltay EJ, Veen G, Penninx BWJH, Zitman FG (2011) Dimensions of depression and anxiety and the hypothalamo-pituitary-adrenal axis. Biol Psychiatry 69:366–373PubMedCrossRef

White B, Mulligan S (2005) Behavioral and physiologic response measures of occupational task performance: a preliminary comparison between typical children and children with attention disorder. Am J Occup Ther 59:426–436PubMedCrossRef

Willcutt E, Pennington B, Chhabildas N, Friedman M, Alexander J (1999) Psychiatric comorbidity associated with DSM-IV ADHD in a nonreferred sample of Twins. J Am Acad Child Adolesc Psychiatry 38:1355–1362PubMedCrossRef

Yang SJ, Shin DW, Noh KS, Mark AS, Mark A (2007) Cortisol is inversely correlated with aggression for those boys with attention deficit hyperactivity disorder who retain their reactivity to stress. Psychiatry Res 153:55–60PubMedCrossRef

Zepf FD, Holtmann M, Stadler C, Demisch L, Schmitt M, Wöckel L, Poustka F (2008) Diminished serotonergic functioning in hostile children with ADHD: tryptophan depletion increases behavioural inhibition. Pharmacopsychiatry 41:60–65PubMedCrossRef

Titel: Cortisol responses in children and adults with attention deficit hyperactivity disorder (ADHD): a possible marker of inhibition deficits
verfasst von: M. Corominas
J. A. Ramos-Quiroga
M. Ferrer
N. Sáez-Francàs
G. Palomar
R. Bosch
M. Casas
Publikationsdatum: 01.06.2012
Verlag: Springer Vienna
Erschienen in: ADHD Attention Deficit and Hyperactivity Disorders / Ausgabe 2/2012
Print ISSN: 1866-6116
Elektronische ISSN: 1866-6647
DOI: https://doi.org/10.1007/s12402-012-0075-5

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