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European Child & Adolescent Psychiatry

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01.09.2009 | Original Contribution

Differences in hypothalamic–pituitary–adrenal axis functioning among children with ADHD predominantly inattentive and combined types

verfasst von: Dirk van West, Stephan Claes, Dirk Deboutte

Erschienen in: European Child & Adolescent Psychiatry | Ausgabe 9/2009

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Abstract

Some evidence suggests that the HPA axis may be dysfunctional in children with attention-deficit/hyperactivity disorder (ADHD). The aim of this study was to investigate whether a different pattern of HPA axis activity is found between the inattentive (I) and combined (C) subtypes of ADHD, in comparison with healthy control children. A total of 100 prepubertal subjects [52 children with ADHD combined type (ADHD-C), 23 children with ADHD predominantly inattentive type (ADHD-I), and 25 healthy control subjects] were studied. The effects of stress were studied by comparing cortisol responses to a psychosocial stressor, consisting of a public speaking task. Children with ADHD-I showed an elevated cortisol response to the psychosocial stressor, in contrast to children with ADHD-C who showed a blunted cortisol response to the psychosocial stressor. When a distinction was made between responders and non-responders (a subject was classified as a responder when there was an increase in cortisol reactivity), hyperactivity symptoms were clearly related to a lower cortisol reactivity to stress. The results indicate that a low-cortisol responsivity to stress may be a neurobiological marker for children with ADHD-C, but not for those with ADHD-I. Directions for future research and clinical implications are discussed.

Aardal E, Holm AC (1995) Cortisol in saliva : reference ranges and relation to cortisol in serum. Eur J Clin Chem Clin Biochem 33:927–932PubMed

Achenbach TM (1991a) Manual for the child behavior checklist and 1991 profile. Department of Psychiatry, University of Vermont, Burlington

Achenbach TM (1991b) Manual for the teacher’s report form and 1991 profile. Department of Psychiatry, University of Vermont, Burlington

American Psychiatric Association (APA) (2000) Diagnostic and statistical manual of mental disorders, text revision, 4th edn. American Psychiatric Press, WashingtonCrossRef

Barkley RA, DuPaul GJ, McMurray MB (1990) Comprehensive evaluation of attention deficit disorder with and without hyperactivity as defined by research criteria. J Consult Clin Psychol 58:775–789PubMedCrossRef

Barkley RA (1997) Behavioral inhibition, sustained attention and executive functions: constructing a unifying theory of ADHD. Psychol Bull 121:65–94PubMedCrossRef

Barkley RA (2001) The inattentive type of ADHD as a distinct disorder: what remain to be done. Clin Psychol Sci Pract 8:489–493CrossRef

Biederman J, Faraone SV (2005) Attention-deficit hyperactivity disorder. Lancet 366:237–248PubMedCrossRef

Biederman J (2005) Attention-deficit/hyperactivity disorder: a selective overview. Biol Psychiatry 57:1215–1220PubMedCrossRef

10.

Biederman J, Faraone SV (2006) The effects of attention-deficit/hyperactivity disorder on employment and household income. MedgenMed 18:12

11.

Blomqvist M, Holmberg K, Lindblad F, Fernell E, Ek U, Dahllöf G (2007) Salivary cortisol levels and dental anxiety in children with attention deficit hyperactivity disorder. Eur J Oral Sci 115:1–6PubMedCrossRef

12.

Carlson M, Earls F (1997) Psychological and neuroendocrinological sequelae of early social deprivation in institutionalized children in Romania. Ann N Y Acad Sci 807:419–428PubMedCrossRef

13.

Carlson CL, Shin M, Booth J (1999) The case for DSM-IV subtypes in ADHD. Ment Retard Dev Disabil Res Rev 5:199–206CrossRef

14.

Carlson CL, Mann M (2002) Sluggish cognitive tempo predicts a different pattern of impairment in the attention deficit hyperactivity disorder, predominantly inattentive type. J Clin Child Adolesc Psychol 31:123–129PubMed

15.

Cohen J (1992) A power primer. Psychol Bull 112:155–159PubMedCrossRef

16.

Diamond A (2005) Attention-deficit disorder (attention-deficit/hyperactivity disorder without hyperactivity): a neurobiologically and behaviourally distinct disorder from attention-deficit/hyperactivity disorder (with hyperactivity). Dev Psychopathol 17:807–825PubMedCrossRef

17.

Dickerson SS, Kemeny ME (2004) Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Psychol Bull 130:355–391PubMedCrossRef

18.

Eiraldi RB, Power TJ, Nezu CM (1997) Patterns of comorbidity associated with subtypes of attention-deficit/hyperactivity disorder among 6- to 12-year old children. J Am Acad Child Adolesc Psychiatry 36:503–514PubMedCrossRef

19.

Faraone SV, Biederman J, Weber W, Russell RL (1998) Psychiatric, neuropsychological and psychosocial features of DSM-IV subtypes of attention-deficit/hyperactivity disorder: results from a clinically referred sample. J Am Acad Child Adolesc Psychiatry 37:185–193PubMed

20.

Farrington DP (1993) Childhood origins of teenage antisocial behavior and adult social dysfunction. J R Soc Med 86:13–17PubMed

21.

Frick PJ (2001) Effective interventions for children and adolescents with conduct disorder. Can J Psychiatry 46:597–608PubMed

22.

Gadow KD, Drabick DA, Loney J, Sprafkin J, Salisbury H, Azizian A, Schwartz J (2004) Comparison of ADHD-symptom subtypes as source-specific syndromes. J Abnorm Child Psychol 45:1135–1149

23.

Gray JA (1982) The neuropsychology of anxiety: an enquiry into the function of the septo-hippocampal system. Oxford University Press, New York

24.

Gray JA (1985) Issues in the neuropsychology of anxiety. In: Tuma AH, De Maser JD (eds) Anxiety and the anxiety disorders. Lawrence Erlbaum, Hillsdale, pp 5–25

25.

Gray JA (1987) The psychology of fear and stress, 2nd edn. Cambridge University Press, Cambridge

26.

Gray JA (1991) Neural systems, emotions and personality. In: Madden J (ed) Neurobiology of learning, emotion and affect. Raven Press, New York, pp 273–306

27.

Hankin BL, Abramson LY, Moffitt TE, Silva PA, McGee R, Angell KE (1998) Development of depression from preadolescence to young adulthood: emerging gender differences in a 10-year longitudinal study. J Abnorm Psychol 107:128–140PubMedCrossRef

28.

Hollingshead AB (1975) Four factor index of social status. Department of Sociology, Yale University, New Haven

29.

Hong HJ, Shin DW, Lee EH, Oh YH, Noh KS (2003) Hypothalamic–pituitary–adrenal reactivity in boys with attention deficit hyperactivity disorder. Yonsei Med J 44:608–614PubMed

30.

Ishii T, Takahashi O, Kawamura Y, Ohta T (2003) Comorbidity in attention deficit-hyperactivity disorder. Psychiatry Clin Neurosci 57:457–463PubMedCrossRef

31.

Kadesjö B, Gillberg C (2001) The comorbidity of ADHD in the general population of Swedish school-age children. J Child Psychol Psychiatry 42:487–492PubMedCrossRef

32.

Kaneko M, Hoshino Y, Hashimoto S, Okano T, Kumashiro H (1993) Hypothalamic–pituitary–adrenal axis function in children with attention-deficit hyperactivity disorder. J Autism Dev Disord 23:59–65PubMedCrossRef

33.

Kariyawasam SH, Zaw F, Handley SL (2002) Reduced salivary cortisol in children with comorbid attention deficit hyperactivity disorder and oppositional defiant disorder. Neuroendocrinol Lett 23:45–48PubMed

34.

Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, Williamson D, Ryan N (1997) Schedule for affective disorders and schizophrenia for school-aged children—present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 35:980–988CrossRef

35.

King JA, Barkley RA, Barrett S (1998) Attention-deficit hyperactivity disorder and the stress response. Biol Psychiatry 44:72–74PubMedCrossRef

36.

Kirschbaum C, Pirke KM, Hellhammer DH (1993) The trier social stress test: a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology 28:76–81PubMedCrossRef

37.

Kirschbaum C, Hellhammer DH (1994) Salivary cortisol in psychoendocrine research: recent developments and applications. Psychoneuroendocrinology 19:313–333PubMedCrossRef

38.

Kudielka BM, Buske-Kirschbaum A, Hellhammer DH, Kirschbaum C (2004) HPA axis responses to laboratory stress in healthy elderly adults, younger adults, and children: impact of age and gender. Psychoneuroendocrinology 29:83–98PubMedCrossRef

39.

Lahey BB, Loeber R, Quay HC, Frick PJ, Grimm J (1992) Oppositional defiant and conduct disorders: issues to be resolved for DSM-IV. J Am Acad Child Adolesc Psychiatry 31:539–546PubMedCrossRef

40.

Lahey BB, Pelham WE, Loney J, Lee SS, Wilcutt E (2005) Instability of the DSM-IV subtypes of ADHD from preschool through elementary school. Arch Gen Psychiatry 62:896–902PubMedCrossRef

41.

Loeber R, Green SM, Keenan K, Lahey BB (1995) Which boys will fare worse ? Early predictors of the onset of conduct disorder in a 6-year longitudinal study. J Am Acad Child Adolesc Psychiatry 34:499–509PubMed

42.

Lupien SJ, King S, Meaney MJ, McEwen BS (2000) Child’s stress hormone levels correlate with mother’s socioeconomic status and depressive state. Biol Psychiatry 48:976–980PubMedCrossRef

43.

Marshall WA, Tanner JM (1969) Variations in the pattern of pubertal changes in girls. Arch Dis Child 44:291PubMedCrossRef

44.

Marshall RW, Hynd GW, Handwerk MJ, Hall J (1997) Academic underachievement in ADHD subtypes. J Learn Disabil 30:635–642PubMedCrossRef

45.

McBurnett K, Lahey BB, Rathouz PJ, Loeber R (2000) Low salivary cortisol and persistent aggression in boys referred for disruptive behavior. Arch Gen Psychiatry 57:38–43PubMedCrossRef

46.

McBurnett K, Pfiffner LJ, Frick PJ (2001) Symptom properties as a function of ADHD type: an argument for continued study of sluggish cognitive tempo. J Abnorm Child Psychol 29:207–213PubMedCrossRef

47.

McGee R, Feehan M, Williams S, Anderson J (1992) DSM-III disorders from age 11 to age 15 years. J Am Acad Child Adolesc Psychiatry 31:50–59PubMed

48.

Milich R, Balentine AC, Lynam DR (2001) ADHD combined type and ADHD predominantly inattentive type are distinct and unrelated disorders. Clin Psychol Sci Pract 8:463–488CrossRef

49.

Morgan AE, Hynd GW, Riccio CA, Hall J (1996) Validity of DSM-IV ADHD predominantly inattentive and combined types: relationship to previous DSM diagnoses/subtype differences. J Am Acad Child Adolesc Psychiatry 35:325–333PubMedCrossRef

50.

Moss HB, Vanyukov M, Yao JK, Kirillova GP (1999) Salivary cortisol responses in prepubertal boys: the effects of parental substance abuse and association with drug use behavior during adolescence. Biol Psychiatry 45:1293–1299PubMedCrossRef

51.

Oosterlaan J, Sergeant JA (1998) Response inhibition and response re-engagement in attention-deficit/hyperactivity disorder, disruptive, anxious and normal children. Behav Brain Res 94:33–43PubMedCrossRef

52.

Oosterlaan J, Geurts HM, Knol DL, Sergeant JA (2005) Low basal salivary cortisol is associated with teacher-reported symptoms of conduct disorder. Psychiatry Res 134:1–10PubMedCrossRef

53.

Popma A, Jansen LM, Vermeiren R, Steiner H, Raine A, Van Goozen SH, van Engeland H, Doreleijers TA (2006) Hypothalamus pituitary adrenal axis and autonomic activity during stress in delinquent male adolescents and controls. Psychoneuroendocrinology 31:948–957PubMedCrossRef

54.

Power TJ, Costigan TE, Eiraldi RB, Leff SS (2004) Variations in anxiety and depression as a function of ADHD subtypes defined by DSM-IV: do subtype differences exist or not? J Abnorm Child Psychol 32:27–37PubMedCrossRef

55.

Pruessner JC, Kirschbaum C, Meinlschmid G, Hellhammer DH (2003) Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology 28:916–931PubMedCrossRef

56.

Quay HC (1997) Inhibition and attention deficit hyperactivity disorder. J Abnorm Psychol 25:7–13

57.

Randazzo WT, Dockray S, Susman EJ (2008) The stress response in adolescents with inattentive type ADHD symptoms. Child Psychiatry Hum Dev 39:27–38PubMedCrossRef

58.

Reichart CG, Wals M, Hillegers M (2000) Vertaling K-SADS. H.C. Rümke Groep, Utrecht

59.

Ryan ND (1998) Psychoneuroendocrinology of children and adolescents. Psychiatr Clin North Am 21:435–441PubMedCrossRef

60.

Schachar RJ, Tannock R, Logan G (1993) Inhibitory, control, impulsiveness, and attention deficit hyperactivity disorder. Clin Psychol Rev 13:721–739CrossRef

61.

Schmidt LA, Fox NA, Rubin KH, Sternberg EM, Gold PW, Smith CC (1997) Behavioral and neuroendocrine responses in shy children. Dev Psychobiol 30:127–140PubMedCrossRef

62.

Scholte EM, van der Ploeg JD (1998) Handleiding ADHD-vragenlijst (AVL). Swets Test Publishers, Lisse

63.

Schulz KP, Halperin JM, Newcorn JH, Sharma V, Gabriel S (1997) Plasma cortisol and aggression in Boys with ADHD. J Am Acad Child Adolesc Psychiatry 36:605–609PubMedCrossRef

64.

Sondeijker FE, Ferdinand RF, Oldehinkel AJ, Veenstra R, Tiemeier H, Ormel J, Verhulst FC (2007) Disruptive behaviors and HPA-axis activity in young adolescent boys and girls from the general population. J Psychiatr Res 41:570–578PubMedCrossRef

65.

Sonuga-Barke EJS (2002) Psychological heterogeneity in AD/HD—a dual pathway model of Behaviour and cognition. Behav Brain Res 130:29–36PubMedCrossRef

66.

Sulon J, Demey-Ponsart L, Beauduin P, Sodoyez JC (1978) Radioimmunoassay of corticosterone, cortisol and cortisone: their application to human cord and maternal plasma. J Steroid Biochem 9:671–676PubMedCrossRef

67.

Takahashi K, Miyawaki D, Suzuki F, Mamoto A, Matsushima N, Tsuji H, Horino A, Ballas PA, Kiriike N (2007) Hyperactivity and comorbidity in Japanese children with attention-deficit/hyperactivity disorder. Psychiatry Clin Neurosci 61:255–262PubMedCrossRef

68.

Van Goozen SH, Matthys W, Cohen-Kettenis PT, Gispen-de Wied C, Wiegant VM, van Engeland H (1998) Salivary cortisol and cardiovascular activity during stress in oppositional-defiant disorder boys and normal controls. Biol Psychiatry 43:531–539PubMedCrossRef

69.

van West D, Claes S, Sulon J, Deboutte D (2008) HPA reactivity in prepubertal children with social phobia. J Affect Disord 111:281–290PubMedCrossRef

70.

Verhulst FC, Van der Ende J (1993) “Comorbidity” in an epidemiological sample: a longitudinal perspective. J Child Psychol Psychiatry 34:767–783PubMedCrossRef

71.

Vila G, Zipper E, Dabbas M, Bertrand C, Robert JJ, Ricour C, Mouren-Simeoni MC (2004) Mental disorders in obese children and adolescents. Psychosom Med 66:387–394PubMedCrossRef

72.

Wechsler D (1974) Wechsler intelligence scale for children-revised. Psychological Corporation, New York

73.

Weiss M, Worling D, Wasdell M (2003) A chart review study of the inattentive and combined types of ADHD. J Atten Disord 7:1–9PubMedCrossRef

74.

Welsh MC, Pennington BF, Groisser DB (1988) A normative-developmental study of executive functioning: a window on prefrontal function in children. Dev Neuropsychol 7:131–149CrossRef

75.

Yang SJ, Shin DW, Noh KS, Stein MA (2007) Cortisol is inversely correlated with aggression for those boys with attention deficit hyperactivity disorder who retain their reactivity to stress. Psychiatry Res 153:55–60PubMedCrossRef

Titel: Differences in hypothalamic–pituitary–adrenal axis functioning among children with ADHD predominantly inattentive and combined types
verfasst von: Dirk van West
Stephan Claes
Dirk Deboutte
Publikationsdatum: 01.09.2009
Verlag: D. Steinkopff-Verlag
Erschienen in: European Child & Adolescent Psychiatry / Ausgabe 9/2009
Print ISSN: 1018-8827
Elektronische ISSN: 1435-165X
DOI: https://doi.org/10.1007/s00787-009-0011-1

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