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Current Breast Cancer Reports
Erschienen in: Current Breast Cancer Reports 1/2013

01.03.2013 | Systemic Therapy (J Cortes, Section Editor)

New Microtubule Inhibitors in Breast Cancer

verfasst von: Cristian B. Villanueva, Fernando F. Bazan, Xavier B. Pivot

Erschienen in: Current Breast Cancer Reports | Ausgabe 1/2013

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Abstract

Chemotherapy is still the main basis of treatment of metastatic breast cancer. Antimicrotubule agents regulating polymerization and depolymerization seem to be involved in a crucial physiopathogenic pathway controlling tumor growth. Such agents as paclitaxel and docetaxel have high activity and a survival benefit as first-line treatment for metastatic cancer, but several mechanisms of acquired resistance lead to refractory disease. Finding new active chemotherapeutic agents able to avoid such chemoresistance is a challenge. In this paper we review of the current state of development of new microtubule inhibitors.
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Metadaten
Titel
New Microtubule Inhibitors in Breast Cancer
verfasst von
Cristian B. Villanueva
Fernando F. Bazan
Xavier B. Pivot
Publikationsdatum
01.03.2013
Verlag
Current Science Inc.
Erschienen in
Current Breast Cancer Reports / Ausgabe 1/2013
Print ISSN: 1943-4588
Elektronische ISSN: 1943-4596
DOI
https://doi.org/10.1007/s12609-012-0101-9

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