Erschienen in:
01.08.2014 | Brief Communications
Thrombin-Induced Cerebral Hemorrhage: Role of Protease-Activated Receptor-1
verfasst von:
Yingying Cheng, Guohua Xi, Hang Jin, Richard F. Keep, Jiachun Feng, Ya Hua
Erschienen in:
Translational Stroke Research
|
Ausgabe 4/2014
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Abstract
Thrombin causes blood–brain barrier disruption, and this study examined whether thrombin can cause brain hemorrhage through protease-activated receptor-1 (PAR-1). Male wild type and PAR-1 knockout mice had an intracerebral injection of thrombin or saline. Mice then underwent serial T2 magnetic resonance imaging and were euthanized for brain hemoglobin, iron, and interleukin-1β measurements. Thrombin caused massive T2 lesions and brain hemorrhage in wild type mice. These effects were markedly reduced in PAR-1 knockout mice. Thrombin also increased brain interleukin-1β, and this was absent in PAR-1 knockout mice. In conclusion, thrombin increases interleukin-1β levels and induces intracerebral hemorrhage through PAR-1 activation.