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Translational Stroke Research
Erschienen in: Translational Stroke Research 5/2014

01.10.2014 | Review Article

Molecular and Cellular Immune Responses to Ischemic Brain Injury

verfasst von: Hilary A. Seifert, Keith R. Pennypacker

Erschienen in: Translational Stroke Research | Ausgabe 5/2014

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Abstract

Despite extensive research into stroke pathology, there have not been any major recent advancements in stroke therapeutics. Animal models of cerebral ischemia and clinical data have been used to investigate the progressive neural injury that occurs after an initial ischemic insult. This has lead researchers to focus more on the peripheral immune response that is generated as a result of cerebral ischemia. The therapies that have been developed as a result of this research thus far have proven ineffective in clinical trials. The failure of these therapeutics in clinical trials is thought to be due to the broad immunosuppression elicited as a result of the treatments and the cerebral ischemia itself. Emerging evidence indicates a more selective modulation of the immune system following stroke could be beneficial. The spleen has been shown to exacerbate neural injury following experimental stroke and would provide a strong therapeutic target. Selecting facets of the immune system to target would allow the protective and regenerative properties of the immune response to remain intact while blunting the pro-inflammatory response generated towards the injured brain.
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Metadaten
Titel
Molecular and Cellular Immune Responses to Ischemic Brain Injury
verfasst von
Hilary A. Seifert
Keith R. Pennypacker
Publikationsdatum
01.10.2014
Verlag
Springer US
Erschienen in
Translational Stroke Research / Ausgabe 5/2014
Print ISSN: 1868-4483
Elektronische ISSN: 1868-601X
DOI
https://doi.org/10.1007/s12975-014-0349-7

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