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Translational Stroke Research

Erschienen in:

08.02.2020 | Original Article

FasL-PDPK1 Pathway Promotes the Cytotoxicity of CD8⁺ T Cells During Ischemic Stroke

verfasst von: Lizhen Fan, Cun-Jin Zhang, Liwen Zhu, Jian Chen, Zhi Zhang, Pinyi Liu, Xiang Cao, Hailan Meng, Yun Xu

Erschienen in: Translational Stroke Research | Ausgabe 4/2020

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Abstract

CD8⁺ T cells are recognized as key players in exacerbation of ischemic stroke; however, the underlying mechanism in modulating the function of CD8⁺ T cells has not been completely elucidated. Here, we uncovered that FasL enhanced the cytotoxicity of CD8⁺ T cells to neurons after ischemic stroke. Inactivation of FasL specific on CD8⁺ T cells protected against brain damage and neuron loss. Proteomic analysis identified that PDPK1 functioned downstream of FasL signaling and inhibition of PDPK1 effectively reduced cytotoxicity of CD8⁺ T cells and improved ischemic neurological deficits. Taken together, these results highlight an intrinsic FasL-PDPK1 pathway regulating the cytotoxicity of CD8⁺ T cells in ischemic stroke.

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Titel: FasL-PDPK1 Pathway Promotes the Cytotoxicity of CD8+ T Cells During Ischemic Stroke
verfasst von: Lizhen Fan
Cun-Jin Zhang
Liwen Zhu
Jian Chen
Zhi Zhang
Pinyi Liu
Xiang Cao
Hailan Meng
Yun Xu
Publikationsdatum: 08.02.2020
Verlag: Springer US
Erschienen in: Translational Stroke Research / Ausgabe 4/2020
Print ISSN: 1868-4483
Elektronische ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-019-00749-0

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FasL-PDPK1 Pathway Promotes the Cytotoxicity of CD8⁺ T Cells During Ischemic Stroke

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