Introduction
Methods
Study Subjects
Outcome Measures and Measurements
Statistical Analysis
Results
Subject Characteristics
Total | IDeg–IGlar | IGlar–IDeg |
p value | |
---|---|---|---|---|
n (male/female) | 20 (11/9) | 10 (5/5) | 10 (6/4) | |
Age (years) | 54 ± 16 | 55 ± 14 | 53 ± 18 | 0.383 |
Diabetes (years) | 15.2 ± 8.5 | 14.4 ± 8.6 | 16.1 ± 8.7 | 0.333 |
Body weight (kg) | 62.0 ± 11.1 | 64.0 ± 10.4 | 60.0 ± 12.0 | 0.218 |
BMI (kg/m2) | 23.7 ± 4.3 | 24.4 ± 4.4 | 23.1 ± 4.1 | 0.256 |
HbA1c (%) | 7.4 ± 0.8 | 7.1 ± 0.9 | 7.7 ± 0.6 | 0.077 |
Total daily dose of insulin (U/kg) | 0.68 ± 0.27 | 0.64 ± 0.23 | 0.72 ± 0.32 | 0.239 |
Basal insulin percentage of TDD (%) | 41.4 ± 18.2 | 47.4 ± 21.2 | 34.9 ± 16.1 | 0.689 |
Glycemic Control
Total | IDeg | IGlar |
p value | |
---|---|---|---|---|
n
| 40 | 20 | 20 | |
Body weight (kg) | 61.7 ± 12.7 | 61.5 ± 12.5 | 61.9 ± 12.9 | 0.945 |
BMI (kg/m2) | 23.6 ± 4.6 | 23.5 ± 4.7 | 23.6 ± 4.6 | 0.884 |
HbA1c (%) | 7.2 ± 0.9 | 7.2 ± 0.8 | 7.3 ± 0.9 | 0.733 |
Total daily dose of insulin (U/kg) | 0.64 ± 0.2 | 0.62 ± 0.21 | 0.65 ± 0.2 | 0.916 |
Basal insulin percentage of TDD (%) | 42.3 ± 16.3 | 42.5 ± 16.9 | 42.1 ± 15.7 | 0.755 |
IDeg | IGlar |
p value | |
---|---|---|---|
Number of CGM records | 20 | 20 | |
Mean glucose value (mg/dL) | 140.1 ± 40.5 | 143.2 ± 28.4 | 0.435 |
Optimum glucose value, 70–140 mg/dL (%) | 50.5 ± 21.2 | 49.3 ± 18.8 | 0.434 |
Total hypoglycemia (%) | 6.6 ± 9.2 | 5.4 ± 6.5 | 0.300 |
Nocturnal hypoglycemia (%) | 39.6 ± 30.6 | 35.1 ± 25.3 | 0.325 |
Mean amplitude of glycemic excursions (MAGE) | 159.7 ± 65.6 | 168.5 ± 57.7 | 0.355 |
J-index | 41.2 ± 24.5 | 42.3 ± 18.1 | 0.444 |
Mean fasting interstitial glucose (mg/dL) | 117.7 ± 44.4 | 137.1 ± 30.5 | 0.102 |
Day-to-day variation of fasting interstitial glucose (mg/dL) | 25.9 ± 22.0 | 43.8 ± 30.1 | 0.037 |