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Neurotherapeutics
Erschienen in: Neurotherapeutics 3/2019

01.07.2019 | Review

Exercise for Brain Health: An Investigation into the Underlying Mechanisms Guided by Dose

verfasst von: Danylo F. Cabral, Jordyn Rice, Timothy P. Morris, Tatjana Rundek, Alvaro Pascual-Leone, Joyce Gomes-Osman

Erschienen in: Neurotherapeutics | Ausgabe 3/2019

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Abstract

There is a strong link between the practice of regular physical exercise and maintenance of cognitive brain health. Animal and human studies have shown that exercise exerts positive effects on cognition through a variety of mechanisms, such as changes in brain volume and connectivity, cerebral perfusion, synaptic plasticity, neurogenesis, and regulation of trophic factors. However, much of this data has been conducted in young humans and animals, raising questions regarding the generalizability of these findings to aging adults. Furthermore, it is not clear at which doses these effects might take place, and if effects would differ with varying exercise modes (such as aerobic, resistance training, combinations, or other). The purpose of this review is to summarize the evidence on the effects of exercise interventions on various mechanisms believed to support cognitive improvements: cerebral perfusion, synaptic neuroplasticity, brain volume and connectivity, neurogenesis, and regulation of trophic factors. We synthesized the findings according to exposure to exercise (short- [1 day-16 weeks], medium- [24-40 weeks], and long-term exercise [52 weeks and beyond]) and have limited our discussion of dose effects to studies in aging adults and aged animals (when human data was not available).
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Metadaten
Titel
Exercise for Brain Health: An Investigation into the Underlying Mechanisms Guided by Dose
verfasst von
Danylo F. Cabral
Jordyn Rice
Timothy P. Morris
Tatjana Rundek
Alvaro Pascual-Leone
Joyce Gomes-Osman
Publikationsdatum
01.07.2019
Verlag
Springer International Publishing
Erschienen in
Neurotherapeutics / Ausgabe 3/2019
Print ISSN: 1933-7213
Elektronische ISSN: 1878-7479
DOI
https://doi.org/10.1007/s13311-019-00749-w

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Correction to: Preserving Lysosomal Function in the Aging Brain: Insights from Neurodegeneration

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