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Current Obesity Reports

Erschienen in:

26.04.2018 | Obesity Treatment (CM Apovian, Section Editor)

Intermittent Fasting: Is the Wait Worth the Weight?

verfasst von: Mary-Catherine Stockman, Dylan Thomas, Jacquelyn Burke, Caroline M. Apovian

Erschienen in: Current Obesity Reports | Ausgabe 2/2018

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Abstract

Purpose of Review

We review the underlying mechanisms and potential benefits of intermittent fasting (IF) from animal models and recent clinical trials.

Recent Findings

Numerous variations of IF exist, and study protocols vary greatly in their interpretations of this weight loss trend. Most human IF studies result in minimal weight loss and marginal improvements in metabolic biomarkers, though outcomes vary. Some animal models have found that IF reduces oxidative stress, improves cognition, and delays aging. Additionally, IF has anti-inflammatory effects, promotes autophagy, and benefits the gut microbiome. The benefit-to-harm ratio varies by model, IF protocol, age at initiation, and duration.

Summary

We provide an integrated perspective on potential benefits of IF as well as key areas for future investigation. In clinical trials, caloric restriction and IF result in similar degrees of weight loss and improvement in insulin sensitivity. Although these data suggest that IF may be a promising weight loss method, IF trials have been of moderate sample size and limited duration. More rigorous research is needed.

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Titel: Intermittent Fasting: Is the Wait Worth the Weight?
verfasst von: Mary-Catherine Stockman
Dylan Thomas
Jacquelyn Burke
Caroline M. Apovian
Publikationsdatum: 26.04.2018
Verlag: Springer US
Erschienen in: Current Obesity Reports / Ausgabe 2/2018
Elektronische ISSN: 2162-4968
DOI: https://doi.org/10.1007/s13679-018-0308-9

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Devices and Endoscopic Bariatric Therapies for Obesity

Food Cues and Obesity: Overpowering Hormones and Energy Balance Regulation

Stress and Obesity: Are There More Susceptible Individuals?

Obesity Prevention and Management Strategies in Canada: Shifting Paradigms and Putting People First

Early Childhood Obesity Risk Factors: Socioeconomic Adversity, Family Dysfunction, Offspring Distress, and Junk Food Self-Medication

Future Pharmacotherapy for Obesity: New Anti-obesity Drugs on the Horizon

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Blutdrucksenkung könnte Uterusmyome verhindern

„Jeder Fall von plötzlichem Tod muss obduziert werden!“

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

Update Innere Medizin