Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Typ-2-Diabetes und Adipositas Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Die Highlights vom Kongress des American College of Cardiology 2024

Im April diskutierten die Herz-Kreislauf-Spezialisten aus der ganzen Welt auf dem  Kongress des American College of Cardiology (ACC) u.a. neue Therapieansätze bei akutem Myokardinfarkt, koronarer Herzerkrankung, kardiogenem Schock oder Aortenklappenstenose. In unserem Kongress-Dossier haben wir für Sie Berichte über die „Late-Breaking Trials“ und andere wichtige Studien zusammengestellt. 
Erweiterte Suche
Anmelden
nach oben
Current Pediatrics Reports
Erschienen in: Current Pediatrics Reports 4/2021

01.12.2021 | Critical Care (R Pierce, Section Editor)

Short-term Cardiovascular Complications of Multi-system Inflammatory Syndrome in Children (MIS-C) in Adolescents and Children

verfasst von: Omar I. Hejazi, Yue-Hin Loke, Ashraf S. Harahsheh

Erschienen in: Current Pediatrics Reports | Ausgabe 4/2021

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

We provide the readers with a review of cardiac complications in children with multi-system inflammatory syndrome in children (MIS-C) and its short-term outcomes.

Recent Findings

Recent reports described the acute cardiac manifestations of MIS-C in children and provided a glimpse of the short-term outcomes.

Summary

Children with MIS-C have been reported to acutely have variable degrees of cardiac findings including abnormal cardiac enzymes, abnormal electrocardiographs, decreased systolic function, coronary artery abnormalities from coronary dilation to giant aneurysms, mitral valve regurgitation, tricuspid valve regurgitation, aortic valve insufficiency, pericardial effusion, diastolic dysfunction, abnormal cardiac strain, and abnormal cardiac MRI. The majority of these abnormalities resolved during short-term follow-up. Further studies are needed to assess if transient or persistent cardiac complications are associated with long-term adverse cardiac events in children with MIS-C.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
2.
3.
• Loke YH, Berul CI, Harahsheh AS. Multisystem inflammatory syndrome in children: is there a linkage to Kawasaki disease? Trends Cardiovasc Med. 2020;30(7):389-396. A review article discussing similarities and differences between MIS-C and Kawasaki disease.
4.
DeBiasi RL, Song X, Delaney M, et al. Severe coronavirus disease-2019 in children and young adults in the Washington, DC, Metropolitan Region. J Pediatr. 2020;223:199–203 e191.
5.
Harahsheh AS, Selekman RE, Simpson JN, et al. Children’s hospital ambulatory response to the 2019 novel coronavirus disease (COVID-19) pandemic. J Ambul Care Manage. 2021.
6.
Harahsheh AS, Dahdah N, Newburger JW, et al. Missed or delayed diagnosis of Kawasaki disease during the 2019 novel coronavirus disease (COVID-19) pandemic. J Pediatr. 2020;222:261–2.
7.
Mahmoud S, Fouda EM, Kotby A, et al. The “golden hours” algorithm for the management of the multisystem inflammatory syndrome in children (MIS-C). Glob Pediatr Health. 2021;8:2333794X21990339.
8.
• Whittaker E, Bamford A, Kenny J, et al. Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2. JAMA. 2020;324(3):259–269. Landmark paper comparing MIS-C to historical Kawasaki disease.
9.
Harahsheh AS, Dahdah N, Newburger JW, et al. Reply. J Pediatr. 2020;224:184–185.e1.
10.
Abdel-Haq N, Asmar BI, Deza Leon MP, et al. SARS-CoV-2-associated multisystem inflammatory syndrome in children: clinical manifestations and the role of infliximab treatment. Eur J Pediatr. 2021;180(5):1581–91.
11.
•• DeBiasi RL, Harahsheh AS, Srinivasalu H, et al. Multisystem inflammatory syndrome of children: sub-phenotypes, risk factors, biomarkers, cytokine profiles and viral sequencing. J Pediatr. 2021;237:125–135.e18. A prospective case control study comparing MIS-C sub-phenotypes to controls.
12.
•• Elias MD, McCrindle BW, Larios G, et al. Management of multisystem inflammatory syndrome in children associated with COVID-19: a survey from the International Kawasaki Disease Registry. CJC Open. 2020;2(6):632-640. International survey describing therapeutic strategies in children with MIS-C.
13.
•• Belay ED, Abrams J, Oster ME, et al. Trends in geographic and temporal distribution of US children with multisystem inflammatory syndrome during the COVID-19 pandemic. JAMA Pediatr. 2021 Aug 1;175(8):837–45. One of the largest US-based MIS-C cohort comparing early to late onset cases.
14.
Valverde I, Singh Y, Sanchez-de-Toledo J, et al. Acute cardiovascular manifestations in 286 children with multisystem inflammatory syndrome associated with COVID-19 infection in Europe. Circulation. 2021;143(1):21–32.CrossRef
15.
Caro-Paton GL, de Azagra-Garde AM, Garcia-Salido A, Cabrero-Hernandez M, Tamariz A, Nieto-Moro M. Shock and myocardial injury in children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection: what we know. Case Series and Review of the Literature. J Intensive Care Med. 2021;36(4):392–403.CrossRef
16.
Minocha PK, Phoon CKL, Verma S, Singh RK. Cardiac findings in pediatric patients with multisystem inflammatory syndrome in children associated with COVID-19. Clin Pediatr (Phila). 2021;60(2):119–26.CrossRef
17.
Jain S, Nolan SM, Singh AR, et al. Myocarditis in multisystem inflammatory syndrome in children associated with coronavirus disease 2019. Cardiol Rev. 2020;28(6):308–11.CrossRef
18.
Vukomanovic V, Krasic S, Minic P, et al. Kawasaki-like disease and acute myocarditis in the SARS-CoV-2 pandemic—reports of three adolescents. Bosn J Basic Med Sci. 2021;21(2):252.PubMedPubMedCentral
19.
Pouletty M, Borocco C, Ouldali N, et al. Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort. Ann Rheum Dis. 2020;79(8):999–1006.CrossRef
20.
Clark BC, Sanchez-de-Toledo J, Bautista-Rodriguez C, et al. Cardiac abnormalities seen in pediatric patients during the SARS-CoV2 pandemic: an international experience. J Am Heart Assoc. 2020;9(21):e018007.CrossRef
21.
Cattalini M, Della Paolera S, Zunica F, et al. Defining Kawasaki disease and pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection during SARS-CoV-2 epidemic in Italy: results from a national, multicenter survey. Pediatr Rheumatol Online J. 2021;19(1):29.CrossRef
22.
Regev T, Antebi M, Eytan D, et al. Pediatric inflammatory multisystem syndrome with central nervous system involvement and hypocomplementemia following SARS-COV-2 infection. Pediatr Infect Dis J. 2020;39(8):e206–7.CrossRef
23.
Rojahn AE, Gammelsrud KW, Brunvand LI, et al. Multiorgan inflammatory syndrome associated with SARS-CoV-2 in a child. Tidsskr Nor Laegeforen. 2020;140(11).
24.
Kappanayil M, Balan S, Alawani S, et al. Multisystem inflammatory syndrome in a neonate, temporally associated with prenatal exposure to SARS-CoV-2: a case report. Lancet Child Adolesc Health. 2021;5(4):304–8.CrossRef
25.
Bordet J, Perrier S, Olexa C, Gerout AC, Billaud P, Bonnemains L. Paediatric multisystem inflammatory syndrome associated with COVID-19: filling the gap between myocarditis and Kawasaki? Eur J Pediatr. 2021;180(3):877–84.CrossRef
26.
Ramcharan T, Nolan O, Lai CY, et al. Paediatric inflammatory multisystem syndrome: temporally associated with SARS-CoV-2 (PIMS-TS): cardiac features, management and short-term outcomes at a UK tertiary paediatric hospital. Pediatr Cardiol. 2020;41(7):1391–401.CrossRef
27.
Soongswang J, Durongpisitkul K, Nana A, et al. Cardiac troponin T: a marker in the diagnosis of acute myocarditis in children. Pediatr Cardiol. 2005;26(1):45–9.CrossRef
28.
Kim HS, Choi HJ. N-terminal pro-B-type natriuretic peptide levels in children: comparison in cardiac and non-cardiac diseases. Cardiol Young. 2020;30(4):500–4.CrossRef
29.
Bautista-Rodriguez C, Sanchez-de-Toledo J, Clark BC, et al. Multisystem inflammatory syndrome in children: an international survey. Pediatrics. 2021;147(2).
30.
• Matsubara D, Kauffman HL, Wang Y, et al. Echocardiographic findings in pediatric multisystem inflammatory syndrome associated with COVID-19 in the United States. J Am Coll Cardiol. 2020;76(17):1947–1961. Single center study comparing MIS-C to Kawasaki disease and controls.
31.
Belhadjer Z, Meot M, Bajolle F, et al. Acute heart failure in multisystem inflammatory syndrome in children in the context of global SARS-CoV-2 pandemic. Circulation. 2020;142(5):429–36.CrossRef
32.
Margossian R, Schwartz ML, Prakash A, et al. Comparison of echocardiographic and cardiac magnetic resonance imaging measurements of functional single ventricular volumes, mass, and ejection fraction (from the Pediatric Heart Network Fontan Cross-Sectional Study). Am J Cardiol. 2009;104(3):419–28.CrossRef
33.
•• Harahsheh AS, Krishnan A, DeBiasi RL, et al. Cardiac echocardiogram findings of severe acute respiratory syndrome coronavirus-2-associated multi-system inflammatory syndrome in children. Cardiol Young. 2021;5:1–9. https://​doi.​org/​10.​1017/​S104795112100302​4. Single center study assessing risk factors associated with cardiac complications.
34.
•• Lopez L, Colan SD, Frommelt PC, et al. Recommendations for quantification methods during the performance of a pediatric echocardiogram: a report from the Pediatric Measurements Writing Group of the American Society of Echocardiography Pediatric and Congenital Heart Disease Council. J Am Soc Echocardiogr. 2010;23(5):465–495; quiz 576–467. Excellent reference discussing echocardiogram evaluation of children.
35.
•• McCrindle BW, Rowley AH, Newburger JW, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: a scientific statement for health professionals from the American Heart Association. Circulation. 2017;135(17):e927-e999. Excellent reference discussing management of children with Kawasaki disease.
36.
Manlhiot C, Newburger JW, Low T, et al. Low-molecular-weight heparin vs warfarin for thromboprophylaxis in children with coronary artery aneurysms after Kawasaki disease: a pragmatic registry trial. Can J Cardiol. 2020;36(10):1598–607.CrossRef
37.
McCrindle BW, Manlhiot C, Newburger JW, et al. Medium-term complications associated with coronary artery aneurysms after Kawasaki disease: a study from the international Kawasaki Disease Registry. J Am Heart Assoc. 2020;9(15):e016440.CrossRef
38.
Osborne J, Friedman K, Runeckles K, et al. Comparison between currently recommended long-term medical management of coronary artery aneurysms after Kawasaki disease and actual reported management in the last two decades. Pediatr Cardiol. 2021;42(3):676–84.
39.
Teitel DF, Newburger JW, Sutton N, et al. Development and utility of quality metrics for ambulatory pediatric cardiology in Kawasaki disease. Clin Pediatr (Phila). 2020;59(3):245–51.CrossRef
40.
•• Lamrani L, Manlhiot C, Elias MD, et al. Kawasaki disease shock syndrome versus classical Kawasaki disease, a meta-analysis and comparison with SARS-CoV-2 multisystem inflammatory syndrome. Can J Cardiol. 2021;6:S0828-282X(21)00290-7. Excellent systemic review and meta-analysis comparing Kawasaki disease to Kawasaki disease shock syndrome and MIS-C..
41.
Mamishi S, Movahedi Z, Mohammadi M, et al. Multisystem inflammatory syndrome associated with SARS-CoV-2 infection in 45 children: a first report from Iran. Epidemiol Infect. 2020;148:e196.CrossRef
42.
Gaitonde M, Ziebell D, Kelleman MS, et al. COVID-19-related multisystem inflammatory syndrome in children affects left ventricular function and global strain compared with Kawasaki disease. J Am Soc Echocardiogr. 2020;33(10):1285–7.CrossRef
43.
Blondiaux E, Parisot P, Redheuil A, et al. Cardiac MRI in children with multisystem inflammatory syndrome associated with COVID-19. Radiology. 2020;297(3):E283–8.CrossRef
44.
45.
46.
47.
Ferreira VM, Schulz-Menger J, Holmvang G, et al. Cardiovascular magnetic resonance in nonischemic myocardial inflammation: expert recommendations. J Am Coll Cardiol. 2018;72(24):3158–76.CrossRef
48.
Georgiopoulos G, Figliozzi S, Sanguineti F, et al. Prognostic impact of late gadolinium enhancement by cardiovascular magnetic resonance in myocarditis: a systematic review and meta-analysis. Circ Cardiovasc Imaging. 2021;14(1):e011492.CrossRef
49.
Banka P, Robinson JD, Uppu SC, et al. Cardiovascular magnetic resonance techniques and findings in children with myocarditis: a multicenter retrospective study. J Cardiovasc Magn Reson. 2015;17:96.CrossRef
50.
Sachdeva S, Song X, Dham N, Heath DM, DeBiasi RL. Analysis of clinical parameters and cardiac magnetic resonance imaging as predictors of outcome in pediatric myocarditis. Am J Cardiol. 2015;115(4):499–504.CrossRef
51.
Messroghli DR, Moon JC, Ferreira VM, et al. Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2* and extracellular volume: a consensus statement by the Society for Cardiovascular Magnetic Resonance (SCMR) endorsed by the European Association for Cardiovascular Imaging (EACVI). J Cardiovasc Magn Reson. 2017;19(1):75.CrossRef
52.
Farsalinos KE, Daraban AM, Unlu S, Thomas JD, Badano LP, Voigt JU. Head-to-head comparison of global longitudinal strain measurements among nine different vendors: the EACVI/ASE inter-vendor comparison study. J Am Soc Echocardiogr. 2015;28(10):1171–1181, e1172.
53.
Levy PT, Machefsky A, Sanchez AA, et al. Reference ranges of left ventricular strain measures by two-dimensional speckle-tracking echocardiography in children: a systematic review and meta-analysis. J Am Soc Echocardiogr. 2016;29(3):209–225 e206.
54.
Theocharis P, Wong J, Pushparajah K, et al. Multimodality cardiac evaluation in children and young adults with multisystem inflammation associated with COVID-19. Eur Heart J Cardiovasc Imaging. 2021;20;22(8):896–903.
55.
Kobayashi R, Dionne A, Ferraro A, et al. Detailed assessment of left ventricular function in multisystem inflammatory syndrome in children using strain analysis. CJC Open. 2021;3(7):880–7.
56.
•• Sanil Y, Misra A, Safa R, et al. Echocardiographic indicators associated with adverse clinical course and cardiac sequelae in multisystem inflammatory syndrome in children with coronavirus disease 2021;34(8):862–76. J Am Soc Echocardiogr. 2021. Excellent single center paper discussing the use of cardiac strain in the evaluation of children with MIS-C.
57.
Feldstein LR, Tenforde MW, Friedman KG, et al. Characteristics and outcomes of US children and adolescents with multisystem inflammatory syndrome in children (MIS-C) compared with severe acute COVID-19. JAMA. 2021;325(11):1074–87.CrossRef
58.
Penner J, Abdel-Mannan O, Grant K, et al. 6-month multidisciplinary follow-up and outcomes of patients with paediatric inflammatory multisystem syndrome (PIMS-TS) at a UK tertiary paediatric hospital: a retrospective cohort study. Lancet Child Adolesc Health. 2021;5(7):473–82.
Metadaten
Titel
Short-term Cardiovascular Complications of Multi-system Inflammatory Syndrome in Children (MIS-C) in Adolescents and Children
verfasst von
Omar I. Hejazi
Yue-Hin Loke
Ashraf S. Harahsheh
Publikationsdatum
01.12.2021
Verlag
Springer US
Erschienen in
Current Pediatrics Reports / Ausgabe 4/2021
Elektronische ISSN: 2167-4841
DOI
https://doi.org/10.1007/s40124-021-00258-5

Weitere Artikel der Ausgabe 4/2021

Current Pediatrics Reports 4/2021 Zur Ausgabe

Renal (D Noone, Section Editor)

Obesity in Children with Kidney Disease

Technology and Pediatrics (E Eisenstein and Y Evans, Section Editors)

Newest Diabetes-Related Technologies for Pediatric Type 1 Diabetes and Its Impact on Routine Care: a Narrative Synthesis of the Literature

Technology and Pediatrics (E Eisenstein and Y Evans, Section Editors)

Welcoming Healthcare Into Our Virtual Meeting Rooms: Perspective and Perseverance in Pediatric Rheumatology

Invited Commentary

The Expansion of Pediatric Care Through Digital Technology

Renal (D Noone, Section Editor)

IgA Vasculitis: a Review and Update on the Management of Renal and Extrarenal Disease, Highlighting What’s New for Biomarkers and Treatment

Renal (D Noone, Section Editor)

Demystifying the Nephron: a Call to Action

Neu im Fachgebiet Pädiatrie

ADHS-Medikation erhöht das kardiovaskuläre Risiko

16.05.2024 Herzinsuffizienz Nachrichten

Erwachsene, die Medikamente gegen das Aufmerksamkeitsdefizit-Hyperaktivitätssyndrom einnehmen, laufen offenbar erhöhte Gefahr, an Herzschwäche zu erkranken oder einen Schlaganfall zu erleiden. Es scheint eine Dosis-Wirkungs-Beziehung zu bestehen.

Erstmanifestation eines Diabetes-Typ-1 bei Kindern: Ein Notfall!

16.05.2024 DDG-Jahrestagung 2024 Kongressbericht

Manifestiert sich ein Typ-1-Diabetes bei Kindern, ist das ein Notfall – ebenso wie eine diabetische Ketoazidose. Die Grundsäulen der Therapie bestehen aus Rehydratation, Insulin und Kaliumgabe. Insulin ist das Medikament der Wahl zur Behandlung der Ketoazidose.

Frühe Hypertonie erhöht späteres kardiovaskuläres Risiko

16.05.2024 Arterielle Hypertonie in der Pädiatrie Nachrichten

Wie wichtig es ist, pädiatrische Patienten auf Bluthochdruck zu screenen, zeigt eine kanadische Studie: Hypertone Druckwerte in Kindheit und Jugend steigern das Risiko für spätere kardiovaskuläre Komplikationen.

Betalaktam-Allergie: praxisnahes Vorgehen beim Delabeling

16.05.2024 Pädiatrische Allergologie Nachrichten

Die große Mehrheit der vermeintlichen Penicillinallergien sind keine. Da das „Etikett“ Betalaktam-Allergie oft schon in der Kindheit erworben wird, kann ein frühzeitiges Delabeling lebenslange Vorteile bringen. Ein Team von Pädiaterinnen und Pädiatern aus Kanada stellt vor, wie sie dabei vorgehen.

Update Pädiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise