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American Journal of Clinical Dermatology
Erschienen in: American Journal of Clinical Dermatology 4/2014

01.08.2014 | Review Article

Optimal Management of Skin Cancer in Immunosuppressed Patients

verfasst von: Lauren Brin, Adeel S. Zubair, Jerry D. Brewer

Erschienen in: American Journal of Clinical Dermatology | Ausgabe 4/2014

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Abstract

Skin cancer is the most common malignancy in humans with basal cell carcinoma representing the majority of cases in the general population. The prevalence of skin cancer is increased amongst immunosuppressed patients such as those with lymphoproliferative disorders including non-Hodgkin lymphoma and chronic lymphocytic leukemia or those with iatrogenic immunosuppression following organ transplantation. In addition, these patients experience greater morbidity and mortality associated with skin cancers. The most common skin cancer in immunosuppressed patients is squamous cell carcinoma, which often presents with more aggressive features and has a greater rate of metastasis. This article reviews the risk factors, etiology, clinical presentation, and prevalence of skin cancer amongst immunosuppressed patients, including organ transplant, lymphoproliferative disorders, autoimmune disorders, and human immunodeficiency virus. We also provide a comprehensive review of treatment guidelines for immunosuppressed patients with cutaneous malignancy. Surgical therapy is the cornerstone of treatment; however, we also discuss pharmacologic treatment options, lifestyle modifications, and revision of immunosuppressive regimens.
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Metadaten
Titel
Optimal Management of Skin Cancer in Immunosuppressed Patients
verfasst von
Lauren Brin
Adeel S. Zubair
Jerry D. Brewer
Publikationsdatum
01.08.2014
Verlag
Springer International Publishing
Erschienen in
American Journal of Clinical Dermatology / Ausgabe 4/2014
Print ISSN: 1175-0561
Elektronische ISSN: 1179-1888
DOI
https://doi.org/10.1007/s40257-014-0085-5

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