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01.10.2019 | Review Article

Clinical Management of Pharmacokinetic Drug Interactions with Direct Oral Anticoagulants (DOACs)

verfasst von: Megan C. Herink, Yan F. Zhuo, Craig D. Williams, Thomas G. DeLoughery

Erschienen in: Drugs | Ausgabe 15/2019

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Abstract

Compared with warfarin, the direct-acting oral anticoagulants (DOAC) have fewer pharmacokinetic drug interactions. However, significant drug interactions do exist with documented changes in DOAC concentrations, which can exceed 100%. Unlike warfarin, DOACs have no validated surrogate test to monitor the intensity of anticoagulation. However, several analyses of major outcomes trials with DOACs have demonstrated that serum concentrations do affect both the thrombotic benefits and the hemorrhagic risks of these agents. This paper reviews the known significant pharmacokinetic interactions with DOACs and includes considerations for their use in the presence of interacting medications.

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Titel: Clinical Management of Pharmacokinetic Drug Interactions with Direct Oral Anticoagulants (DOACs)
verfasst von: Megan C. Herink
Yan F. Zhuo
Craig D. Williams
Thomas G. DeLoughery
Publikationsdatum: 01.10.2019
Verlag: Springer International Publishing
Erschienen in: Drugs / Ausgabe 15/2019
Print ISSN: 0012-6667
Elektronische ISSN: 1179-1950
DOI: https://doi.org/10.1007/s40265-019-01183-0

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Clinical Management of Pharmacokinetic Drug Interactions with Direct Oral Anticoagulants (DOACs)

Abstract

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

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