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Molecular Diagnosis & Therapy

Erschienen in:

01.12.2012 | Review Article

Biomarkers of Therapeutic Response to BCL2 Antagonists in Cancer

verfasst von: Lloyd T. Lam, Haichao Zhang, Brenda Chyla

Erschienen in: Molecular Diagnosis & Therapy | Ausgabe 6/2012

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Abstract

Cancer cells persist by resisting programmed cell death or apoptosis. In particular, an imbalance of proteins that regulate apoptosis leads to lack of response to apoptotic stimuli. Thus, restoring the ability of cancer cells to undergo apoptosis is highly desirable. One apoptosis pathway, the intrinsic pathway, involves perturbation of the mitochondria. The major players of this pathway are the members of the B cell CLL/lymphoma 2 (BCL2) family. Currently, three BCL2 antagonists are in clinical trials for cancer treatment. While these antagonists show various specificity and potency, the development of companion diagnostics is crucial for developing these compounds into viable cancer treatments. In this review we describe predictive and pharmacodynamic biomarkers for these agents. Future directions on biomarker development for this class of antagonist are also discussed.

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Titel: Biomarkers of Therapeutic Response to BCL2 Antagonists in Cancer
verfasst von: Lloyd T. Lam
Haichao Zhang
Brenda Chyla
Publikationsdatum: 01.12.2012
Verlag: Springer International Publishing AG
Erschienen in: Molecular Diagnosis & Therapy / Ausgabe 6/2012
Print ISSN: 1177-1062
Elektronische ISSN: 1179-2000
DOI: https://doi.org/10.1007/s40291-012-0003-6

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Role of Leptin Receptor (LEPR) Gene Polymorphisms and Haplotypes in Susceptibility to Hepatocellular Carcinoma in Subjects with Chronic Hepatitis B Virus Infection

Molecular-Based Classification of Acute Myeloid Leukemia and Its Role in Directing Rational Therapy

Genetic Testing in Combination with Preventive Donepezil Treatment for Patients with Amnestic Mild Cognitive Impairment

Cardiac Troponins I and T: Molecular Markers for Early Diagnosis, Prognosis, and Accurate Triaging of Patients with Acute Myocardial Infarction

Pharmacogenetics in Kidney Transplantation