Background
Methods
Subject materials
Inflammatory bowel disease
Celiac disease
Psoriasis
Disease | Sample set | Sample size | |
---|---|---|---|
IBD
| Swedish case-controls | UC cases | 455 |
CD cases | 348 | ||
Controls | 280 | ||
Celiac disease
| Finnish families 260 families (185 multiplex, 75 trios) | Affected | 607 |
Unaffected | 379 | ||
Finnish case-controls | Cases | 165 | |
Hungarian families 400 families (204 multiplex, 196 trios) | Affected | 606 | |
Unaffected | 474 | ||
Hungarian case-controls | Cases | 270 | |
Controls | 270 | ||
Italian case-controls | Cases | 139 | |
Controls | 198 | ||
Psoriasis
| Finnish families 255 families (64 multiplex, 191 trios) | Affected | 385 |
Unaffected | 516 | ||
Controls
| Finnish controls (from Lappalainen et al. 2008) | Controls | 292 |
Genotyping and analysis
Results
IL23Rand inflammatory bowel disease
rs1004819*T | rs10489629*C | rs2201841*C | rs11465804*G | rs11209026*A | rs1343151*C | rs10889677*A | rs11209032*A | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N (cases/controls)
|
p-value
|
OR
|
p-value
|
OR
|
p-value
|
OR
|
p-value
|
OR
|
p-value
|
OR
|
p-value
|
OR
|
p-value
|
OR
|
p-value
|
OR
| ||
A
| SWE IBD [UC&CD] | 773/280 |
0.004
| 1.38 |
0.006
| 0.76 | 0.054 |
0.002
| 0.42 |
0.003
| 0.45 |
0.014
| 1.30 | 0.088 | 0.130 | |||
SWE IBD UC | 461/280 |
0.013
| 1.36 |
0.002
| 0.72 |
0.044
| 1.27 |
0.003
| 0.42 |
0.007
| 0.43 |
0.012
| 1.34 | 0.059 | 0.111 | |||
SWE IBD CD | 337/280 |
0.006
| 1.43 |
0.049
| 0.80 | 0.188 |
0.022
| 0.47 |
0.038
| 0.51 |
0.039
| 1.29 | 0.323 | 0.312 | ||||
B
| HUN CEL | 610/269 | 0.273 | 0.665 | 0.444 | 0.220 | 0.390 | 0.492 | 0.335 | 0.546 | ||||||||
FIN CEL | 460/292 | 0.400 | 0.773 | 0.401 | 0.874 | 0.503 | 0.247 | 0.499 | 0.634 | |||||||||
ITA CEL | 138/194 | 0.803 | 0.324 | 0.390 | 0.753 | 0.778 | 0.570 | 0.334 | 0.491 | |||||||||
ALL CEL | 1208/750 | 0.524 | 0.865 | 0.846 | 0.279 | 0.677 | 0.399 | 0.849 | 0.424 | |||||||||
C
| FIN PSOR | 250/292 | 0.853 | 0.203 | 0.619 | 0.186 | 0.357 | 0.776 | 0.808 | 0.582 |
IL23Rand celiac disease
A
|
Celiac disease
| Samples | max Z-value | max lod | max lod p-value |
---|---|---|---|---|---|
Finnish families (135) | 3.19 | 3.24 | 0.00006 | ||
Hungarian families (132) | 1.25 | 0.4 | 0.08 | ||
Finnish and Hungarian families (268) | 3.22 | 3.04 | 0.00009 | ||
B
|
Celiac disease-DH vs. non-DH
|
Samples
|
max Z-value
|
max lod
|
max lod p-value
|
Finnish DH (34) | 1.87 | 1.03 | 0.015 | ||
Finnish non-DH (74) | 2.53 | 1.71 | 0.0013 | ||
Hungarian DH (11) | 0.14 | 0.01 | 0.4 | ||
Hungarian non-DH (121) | 1.01 | 0.28 | 0.13 | ||
C
|
Psoriasis
|
Samples
|
max Z-value
|
max lod
|
max lod p-value
|
Finnish families (51) | 1.49 | 0.83 | 0.03 |