Background
Methods
Study Population and Setting
Endpoint Assessment
Statistical Analysis
Results
Variable | Total Population (n = 4,174) | Derivation sample (n = 300) | Validation sample (n = 100) | Unselected patients (n = 3,774) | P-value* |
---|---|---|---|---|---|
Age (years) -- mean ± SD | 67 ± 14 | 67 ± 14 | 68 ± 14 | 67 ± 14 | 0.47 |
Male -- no.(%) | 2011 (48%) | 155 (52%) | 46 (46%) | 1810 (48%) | 0.42 |
White -- no. (%) | 2615 (63%) | 61% | 59% | 63% | 0.12 |
Hypertension -- no. (%) | 3384 (81%) | 244 (81%) | 77 (77%) | 3063 (81%) | 0.57 |
Diabetes -- no. (%) | 1409 (34%) | 104 (35%) | 31 (31%) | 1274 (34%) | 0.80 |
Chronic obstructive pulmonary disease - no. (%) | 600 (14%) | 46 (15%) | 12 (12%) | 542 (14%) | 0.71 |
Coronary Atherosclerosis - no. (%) | 829 (20%) | 42 (14%) | 15 (15%) | 772 (20%) | 0.012 |
≥1 BNP measurement during the study period - no. (%) | 2374 (57%) | 170 (57%) | 53 (53%) | 2151 (57%) | 0.73 |
Maximum BNP level - median (interquartile range) | 198 (88-494) | 192 (84-500) | 144 (90-379) | 201 (89-500) | 0.634 |
# | Heart failure criteria based on claims and laboratory data | Sensitivity | Specificity | AUC |
---|---|---|---|---|
1 | ≥2 heart failure encounters OR any hospital discharge diagnosis of heart failure OR BNP ≥ 200 pg/ml | 76.29 | 74.53 | 0.754 |
2 | ≥2 heart failure encounters OR any hospital discharge diagnosis of heart failure | 68.56 | 81.13 | 0.748 |
3 | ≥2 heart failure encounters OR BNP ≥ 200 pg/ml | 69.59 | 79.25 | 0.744 |
4 | ≥2 heart failure encounters OR any hospital discharge diagnosis of heart failure ORBNP ≥ 500 pg/ml | 69.59 | 78.3 | 0.739 |
5 | ≥2 heart failure encounters OR primary hospital discharge diagnosis of heart failure | 60.31 | 85.85 | 0.729 |
6 | ≥2 heart failure encounters OR BNP ≥ 100 pg/ml | 76.29 | 68.87 | 0.726 |
7 | ≥2 heart failure encounters | 58.76 | 85.85 | 0.723 |
8 | ≥2 heart failure encounters AND ≥ 1 BNP ≥ 50 pg/ml OR any hospital discharge diagnosis of heart failure OR ≥ 1 BNP ≥ 200 pg/ml | 59.28 | 81.13 | 0.702 |
9 | ≥2 heart failure encounters AND ≥ 1 BNP ≥ 50 pg/ml OR primary hospital discharge diagnosis of heart failure OR ≥ 1 BNP ≥ 500 pg/ml | 38.66 | 90.57 | 0.646 |
10 | Any hospital discharge diagnosis of heart failure OR BNP ≥ 500 pg/ml | 40.72 | 87.74 | 0.642 |
11 | Any hospital discharge diagnosis of heart failure | 35.05 | 91.51 | 0.633 |
12 | BNP ≥ 100 pg/ml | 48.97 | 76.42 | 0.627 |
13 | BNP ≥ 200 pg/ml | 36.08 | 87.74 | 0.619 |
14 | Primary hospital discharge diagnosis of heart failure OR BNP ≥ 500 pg/ml | 24.23 | 95.28 | 0.598 |
15 | BNP ≥ 500 pg/ml | 20.1 | 95.28 | 0.577 |
16 | Any primary hospital discharge diagnosis of heart failure | 14.95 | 100 | 0.575 |
# | Heart failure criteria based on claims and laboratory data | Sensitivity (%) | Specificity (%) |
AUC
|
---|---|---|---|---|
1 | ≥2 heart failure encounters OR any hospital discharge diagnosis of heart failure OR ≥ 1 BNP level ≥ 200 pg/ml | 78.46 | 68.57 | 0.735 |
2 | ≥2 heart failure encounters OR any hospital discharge diagnosis of heart failure | 70.77 | 74.29 | 0.725 |
3 | ≥2 heart failure encounters OR ≥ 1 BNP level ≥ 200 pg/ml | 63.08 | 82.86 | 0.730 |
4 | ≥2 heart failure encounters OR any hospital discharge diagnosis of heart failure OR≥ 1 BNP ≥ 500 pg/ml | 70.77 | 71.43 | 0.711 |