Diffusion weighted imaging (DWI) gives rise to a unique method to evaluate perfusion and diffusion parameters of a tissue without the need of any contrast agent, with the introduction of the Intravoxel Incoherent Motion (IVIM) model (Le Bihan, Radiology 1988). Despite its relevance, cardiac DWI has so far been limited to low b-values primarily due to signal loss induced by physiological motion. Recently, an efficient cardiac DWI method was proposed where images were acquired at different time points of the cardiac cycle and where motion-induced signal-loss was removed by Principal Component Analysis (PCA) filtering and temporal MIP (tMIP) techniques (PCATMIP) (Rapacchi, Invest Radiol 2011). We compared the IVIM parameters obtained at a single optimized diastolic time point of the cardiac cycle (1TD) to the results obtained with PCATMIP technique.
Methods
Breath-hold DWI scans were performed on 12 volunteers for 10 trigger-delay values in diastole. 13 b-values ranged from 0 to 550 s/mm2 were used. Signal intensity (SI) of the LV myocardium was fitted with the IVIM model corrected for T1/T2 relaxation (Lemke, MRM 2010).
Anzeige
Results
Figure 1 shows examples of DWI for 1TD and PCATMIP as well as maps of IVIM parameters. PCATMIP allowed the recovery of signal loss due to either intra-scan cardiac motion or RR variability over multiple breath-holds (see fig. 2). Perfusion fraction f, diffusion coefficient D and pseudo-diffusion coefficient D* were evaluated. The values of D measured for 1TD and for PCATMIP were similar (2.35±1.12x10-3 mm2/s and 2.35±0.89x10-3 mm2/s respectively, p=0.999). However, f was lower with 1TD than with PCATMIP (0.118±0.067 and 0.163±0.056 respectively, p=0.0018). Average D* obtained was 0.106 mm2/s for 1TD and 0.0763 mm2/s for PCATMIP.
×
×
Conclusions
This study demonstrates feasibility and reports for the first time cardiac IVIM parameters in normal humans. PCATMIP minimized the motion-induced signal loss which is the main problem in cardiac DWI. This study opens new perspectives for perfusion imaging without contrast media.
Funding
This work was supported by the French National Agency for Research (ANR).
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Frauen, die zum Zeitpunkt der Brustkrebsdiagnose eine hohe mammografische Brustdichte aufweisen, haben ein erhöhtes Risiko für ein baldiges Rezidiv, legen neue Daten nahe.
Sie sei „ethisch geboten“, meint Gesundheitsminister Karl Lauterbach: mehr Transparenz über die Qualität von Klinikbehandlungen. Um sie abzubilden, lässt er gegen den Widerstand vieler Länder einen virtuellen Klinik-Atlas freischalten.
Gesundheitsminister Lauterbach hat die vom Bundeskabinett beschlossene Klinikreform verteidigt. Kritik an den Plänen kommt vom Marburger Bund. Und in den Ländern wird über den Gang zum Vermittlungsausschuss spekuliert.
In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.
Update Radiologie
Bestellen Sie unseren Fach-Newsletterund bleiben Sie gut informiert.