Verbal Autopsy (VA) is widely viewed as the only immediate strategy for registering cause of death in much of Africa and Asia, where routine physician certification of deaths is not widely practiced. VA involves a lay interview with family or friends after a death, to record essential details of the circumstances. These data can then be processed automatically to arrive at standardized cause of death information.
Methods
The Population Health Metrics Research Consortium (PHMRC) undertook a study at six tertiary hospitals in low- and middle-income countries which documented over 12,000 deaths clinically and subsequently undertook VA interviews. This dataset, now in the public domain, was compared with the WHO 2012 VA standard and the InterVA-4 interpretative model.
Results
The PHMRC data covered 70% of the WHO 2012 VA input indicators, and categorized cause of death according to PHMRC definitions. After eliminating some problematic or incomplete records, 11,984 VAs were compared. Some of the PHMRC cause definitions, such as ‘preterm delivery’, differed substantially from the International Classification of Diseases, version 10 equivalent. There were some appreciable inconsistencies between the hospital and VA data, including 20% of the hospital maternal deaths being described as non-pregnant in the VA data. A high proportion of VA cases (66%) reported respiratory symptoms, but only 18% of assigned hospital causes were respiratory-related. Despite these issues, the concordance correlation coefficient between hospital and InterVA-4 cause of death categories was 0.61.
Conclusions
The PHMRC dataset is a valuable reference source for VA methods, but has to be interpreted with care. Inherently inconsistent cases should not be included when using these data to build other VA models. Conversely, models built from these data should be independently evaluated. It is important to distinguish between the internal and external validity of VA models. The effects of using tertiary hospital data, rather than the more usual application of VA to all-community deaths, are hard to evaluate. However, it would still be of value for VA method development to have further studies of population-based post-mortem examinations.
The online version of this article (doi:10.1186/1741-7015-12-23) contains supplementary material, which is available to authorized users.
Competing interests
The author declares that he has no competing interests, and points out that the InterVA models which he has developed are entirely public domain assets.
Background
Verbal Autopsy (VA, the practice of interviewing witnesses of a death and processing the information into likely causes of death) is recognized as an important strategy for widening the scope of cause-specific mortality data, particularly in countries where most deaths pass unregistered and unattended by medical professionals. There has been considerable development in recent years of automated procedures for systematically coding VA data into cause of death outcomes, which are seen as a necessary strategy to underpin widespread, rapid and cost-effective approaches to registering cause of death [1].
Inevitably, one of the major challenges to developing fit-for-purpose VA interpretative models is capturing the necessary knowledge in a valid and usable manner. Some models have sought to be entirely based on data, including in some cases the application of machine learning techniques to construct the model’s evidence base [2, 3]. Others have developed systematic approaches to incorporating human medical expertise as the basis of model building [4]. In both cases, there is also an obvious desire to be able to test models with high-quality VA data in order to demonstrate validity in terms of relationships between the input side (VA interview material) and the output side (cause of death assignment) [5, 6].
Anzeige
To meet this need, the Population Health Metrics Research Consortium (PHMRC) undertook a data collection exercise between 2007 and 2010 in four countries (India, Mexico, Tanzania and the Philippines) which documented 12,542 deaths in high-level hospitals where excellent diagnostic facilities were available during final illnesses, and then followed up the deaths with VA interviews [7]. This dataset was dubbed as ‘gold standard’ VA data in findings published in 2011. In October 2013 the dataset was released into the public domain, and this dataset is examined here in terms of its compatibility with the WHO 2012 VA standard [8, 9], its completeness and quality, and consistency between the hospital cause of death categorization and the InterVA-4 model (which is exactly compatible with the WHO 2012 VA standard) [10]. The objectives in undertaking these analyses are to arrive at a better understanding of how useful the PHMRC dataset might be for developing general VA methods and to explore the external validity of the dataset.
Methods
The PHMRC public-domain dataset [11] contains tertiary hospital assignments of cause of death and responses to subsequent VA interviews. The data are divided into three sections according to variations in the VA instrument used for the neonatal period (including stillbirths), childhood (one month to eleven years) and adulthood (twelve years and older). Two separate sites were covered in India (Andra Pradesh and Uttar Pradesh) and Tanzania (Dar es Salaam and Pemba island), with one each in the Philippines (Bohol) and Mexico (Mexico City). The public domain dataset contains slightly fewer cases than were originally reported (12,530 versus 12,542). An overall summary of the data is presented in Table 1 by site, age group and cause of death according to the hospital diagnosis. No hospital data other than the cause of death category are available in the dataset, and the cause categories were pre-defined as previously described [7].
Table 1
Summary of PHMRC VA dataset for 12,530 deaths by cause of death, age group (adult, child and neonate) and site
Site
Andhra Pradesh
Bohol
Dar es Salaam
Mexico City
Pemba
Uttar Pradesh
Total
Cause of death category
Ad
Ch
Ne
Ad
Ch
Ne
Ad
Ch
Ne
Ad
Ch
Ne
Ad
Ch
Ne
Ad
Ch
Ne
AIDS
136
1
203
19
120
43
522
Acute myocardial infarction
101
116
3
76
104
400
Asthma
21
6
12
1
6
1
47
Birth asphyxia
115
50
134
45
66
52
462
Bite of venomous animal
31
33
1
1
33
21
120
Breast cancer
3
28
90
69
5
195
COPD
25
4
2
63
77
171
Cervical cancer
3
9
108
31
4
155
Cirrhosis
51
39
27
133
63
313
Colorectal cancer
7
24
33
35
99
Congenital malformation
63
41
62
61
19
3
249
Diabetes
88
77
59
105
38
47
414
Diarrhea/dysentery
77
35
27
22
37
50
18
8
21
64
48
77
484
Drowning
32
29
4
9
13
4
28
6
33
31
189
Encephalitis
7
34
41
Epilepsy
30
5
6
2
5
48
Esophageal cancer
1
5
34
40
Falls
32
12
38
6
11
1
36
2
26
4
30
24
222
Fires
35
30
7
25
15
18
1
6
7
31
15
190
Hemorrhagic fever
30
13
1
7
51
Homicide
31
35
30
37
3
31
167
Leukemia/lymphomas
7
15
59
72
3
156
Lung cancer
5
23
11
59
8
106
Malaria
29
12
34
102
2
2
35
216
Maternal
71
41
135
39
46
136
468
Measles
1
22
23
Meningitis
6
2
23
27
58
Meningitis/sepsis
2
19
132
7
1
5
166
Other cancers
7
8
2
3
8
28
Other cardiovascular diseases
76
14
78
12
112
32
81
7
69
11
492
Other defined causes of child deaths
31
20
31
48
30
34
194
Other digestive diseases
5
18
9
13
3
48
Other infectious diseases
34
4
51
9
37
9
37
6
3
2
101
37
330
Other injuries
31
7
23
2
3
37
103
Other non-communicable diseases
90
125
171
122
54
37
599
Pneumonia
55
102
7
142
124
18
95
111
43
102
22
41
134
2
105
39
13
1155
Poisonings
30
3
3
3
8
2
9
1
1
35
9
104
Preterm delivery
85
90
244
127
53
61
660
Prostate cancer
1
4
32
11
48
Renal failure
102
68
49
92
105
416
Road traffic
39
33
55
3
31
15
34
2
11
8
32
31
294
Sepsis
29
21
32
10
46
138
Stillbirth
102
156
435
75
119
118
1005
Stomach cancer
5
5
21
31
62
Stroke
125
179
103
122
101
630
Suicide
49
16
13
11
2
33
124
TB
101
22
103
17
6
27
276
Violent death
26
26
52
ALL CAUSES
1,554
449
374
1,259
262
374
1,726
467
1,050
1,586
126
315
297
261
260
1,419
499
252
12,530
Ad, adult; Ch, children; COPD, chronic obstructive pulmonary disease; Ne, neonate; PHMRC, Population Health Metrics Research Consortium; TB, tuberculosis; VA, verbal autopsy.
The VAs that were subsequently performed on the PHMRC hospital deaths used a set of standard forms covering each of the three age groups, yielding databases with structures defined in a spreadsheet [12]. In addition, the original VAs contained an open narrative section which is not available in the public domain dataset, but the dataset does include some machine-extracted variables indicating the presence of certain key words within those narratives. However, in the present analyses it was not possible to make use of those key word variables because no clear distinction was made between narratives containing, for example, the word ‘heartbeat’ in the phrases ‘the baby’s heartbeat was normal’ or ‘the baby had no heartbeat’.
The WHO 2012 VA standard [8] and InterVA-4 [10] define 244 yes/no indicators covering VAs relating to various age and sex groups. A correspondence table between the WHO 2012 indicators and the PHMRC database is available in Additional file 1. Overall 170/244 (69.7%) of the WHO indicators were available in the PHMRC dataset, and these variables were extracted into a dataset for processing using the InterVA-4 model (version 4.02) [13]. Some problems were encountered in the age and sex variables in the PHMRC dataset. Dates of birth and death were recorded in two duplicate sets of variables (g1_01/6 and g5_01/3) as well as duplicate variables for age at death (g1_07 and g5_04). For some individuals there were inconsistencies between these age-related variables, and cases were dropped where these inconsistencies resulted in ambiguities between WHO 2012 age groups. Overall, 494 cases (3.9%) in the PHMRC dataset had no valid age or sex recorded and were excluded from InterVA-4 processing. A further 36 cases (0.3%) reported none of the WHO 2012 symptom indicators and were likewise excluded. Analyses of InterVA-4 outputs are, therefore, based on 11,984 cases.
Anzeige
The InterVA-4 model requires estimates of HIV/AIDS and malaria levels among deaths in what would normally be a population (rather than a group of hospital cases), as described in the User Guide [14]. In the PHMRC study, there was no intention that the deaths recorded were in any way representative of local populations, and so these parameters were set according to the overall levels of HIV/AIDS and malaria according to the hospital causes of death. In Andhra Pradesh, Dar es Salaam and Uttar Pradesh malaria levels were high (>1% of all deaths) while in the remaining sites malaria levels were very low (<0.01%). Similarly for HIV/AIDS, in Bohol and Pemba HIV/AIDS levels were very low (<0.01%), while in the remaining sites the level was high (>1%). InterVA-4 generates from zero to three most likely causes per case, each with an associated likelihood; cases with zero causes reflect complete uncertainty. The sum of the likelihoods for each case was always taken to be one in these analyses, including, where necessary, an indeterminate cause component.
The WHO 2012 VA standard defines 62 cause of death categories (including stillbirths) with corresponding International Classification of Diseases, 10th revision (ICD-10) codes. These differ in some respects from the PHMRC cause categories, and for the purposes of comparison the correspondence between the WHO and PHMRC categories (34 cause version as previously published [7]) is shown in Table 2. The concordance correlation coefficient between cause-specific mortality fractions (CSMF) was calculated using Stata, according to the method described by Lin [15].
Table 2
Working equivalence between WHO 2012 and PHMRC cause of death categories
WHO 2012 VA cause categories
PHMRC cause categories
01.01 Sepsis (non-obstetric)
Sepsis
01.02 Acute resp infect incl pneumonia
Pneumonia
01.03 HIV/AIDS related death
AIDS
01.04 Diarrhoeal diseases
Diarrhea/dysentery
01.05 Malaria
Malaria
01.06 Measles
Measles
01.07 Meningitis and encephalitis
Meningitis; encephalitis
01.08 & 10.05 Tetanus
Other infectious diseases
01.09 Pulmonary tuberculosis
TB
01.10 Pertussis
Other infectious diseases
01.11 Haemorrhagic fever
Hemorrhagic fever
01.99 Other and unspecified infect dis
Other infectious diseases
02.01 Oral neoplasms
Other cancers
02.02 Digestive neoplasms
Esophageal cancer; stomach cancer
02.03 Respiratory neoplasms
Lung cancer
02.04 Breast neoplasms
Breast cancer
02.05 & 02.06 Reproductive neoplasms M/F
Cervical cancer; prostate cancer
02.99 Other and unspecified neoplasms
Leukemia/lymphomas; other cancers
03.01 Severe anaemia
Other non-communicable diseases
03.02 Severe malnutrition
Other non-communicable diseases
03.03 Diabetes mellitus
Diabetes
04.01 Acute cardiac disease
Acute myocardial infarction
04.02 Stroke
Stroke
04.03 Sickle cell with crisis
Other non-communicable diseases
04.99 Other and unspecified cardiac dis
Other cardiovascular diseases
05.01 Chronic obstructive pulmonary dis
COPD
05.02 Asthma
Asthma
06.01 Acute abdomen
Other digestive diseases; other non-communicable diseases
06.02 Liver cirrhosis
Liver cirrhosis
07.01 Renal failure
Renal failure
08.01 Epilepsy
Epilepsy
98 Other and unspecified NCD
Other digestive diseases; other non-communicable diseases
10.06 Congenital malformation
Congenital malformation
10.01 Prematurity
Preterm delivery
10.02 Birth asphyxia
Birth asphyxia
10.03 Neonatal pneumonia
Pneumonia
10.04 Neonatal sepsis
Meningitis/sepsis
10.99 Other and unspecified neonatal CoD
n/a
11.01 Fresh stillbirth
Stillbirth
11.02 Macerated stillbirth
Stillbirth
12.01 Road traffic accident
Road traffic
12.02 Other transport accident
Other injuries
12.03 Accid fall
Falls
12.04 Accid drowning and submersion
Drowning
12.05 Accid expos to smoke fire & flame
Fires
12.06 Contact with venomous plant/animal
Bite of venomous animal
12.10 Exposure to force of nature
Other injuries
12.07 Accid poisoning & noxious subs
Poisonings
12.08 Intentional self-harm
Suicide
12.09 Assault
Homicide; violent death
12.99 Other and unspecified external CoD
Other injuries
09.01 Ectopic pregnancy
Maternal
09.02 Abortion-related death
Maternal
09.03 Pregnancy-induced hypertension
Maternal
09.04 Obstetric haemorrhage
Maternal
09.05 Obstructed labour
Maternal
09.06 Pregnancy-related sepsis
Maternal
09.07 Anaemia of pregnancy
Maternal
09.08 Ruptured uterus
Maternal
09.99 Other and unspecified maternal CoD
Maternal
99 Indeterminate
Other defined causes of child deaths
COPD, chronic obstructive pulmonary disease; PHMRC, Population Health Metrics Research Consortium; TB, tuberculosis; VA, verbal autopsy.
A separate experiment was carried out using the DHS 2010 Afghanistan national mortality survey [16] database as an independent source, to estimate the effect of losing the missing PHMRC VA variables on the overall mortality cause distribution as determined by InterVA-4. This involved running InterVA-4 separately on a dataset extracted from the DHS and then re-running with the non-PHMRC indicators removed.
No specific ethical clearance was required for this study, since it only used the public domain anonymized PHMRC VA dataset, the public domain DHS 2010 Afghanistan dataset and the public domain InterVA-4 model.
Results
From the overall 12,530 cases in the PHMRC VA dataset, 11,984 cases met the basic minimum requirements of the WHO 2012 VA standard (valid age, sex and some symptom data). Among these cases, 1,688 (14.1%) of the PHMRC causes of death fell into categories described as ‘Other…’ which do not represent specific causes of death.
Deaths among women aged 12 to 49 accounted for 1,884/11,984 (15.7%) of the cases, and 458 (24.3%) of these deaths were classified as ‘Maternal’ in the PHMRC dataset. However, 17/1,884 (0.9%) of these deaths had contradictory pregnancy status information in the VA data (for example, both pregnant and recently delivered at death). Of the 458 PHMRC ‘Maternal’ deaths, 90 (19.7%) were not reported in the VA interview to have been pregnant at or within six weeks of death. Hospital diagnoses reported 1,603 neonatal deaths, 107 (6.7%) of which were said to be stillbirths in the VA interviews. The remaining 1,496 neonatal deaths are presented by cause and time in Figure 1. In 147/1,001 (14.7%) deaths which were recorded as stillbirths in hospitals, the circumstances were recorded as neonatal deaths in VA interviews, mostly during the first day of life. However, the symptoms reported in many of these discrepant cases were contradictory, leading to many being categorized as indeterminate in cause by InterVA-4.
×
A high proportion of cases (7,898/11,984; 65.9%) were reported as having respiratory symptoms in the VA interviews, although 2,134/11,984 (17.8%) had respiratory-related PHMRC causes of death assigned. Table 3 shows the proportions of cases reporting various respiratory symptoms for respiratory-related PHMRC causes (2,134/11,984; 17.8%; comprising asthma, birth asphyxia, COPD, lung cancer, pneumonia, TB) and for other PHMRC causes of death.
Table 3
Numbers (%) of verbal autopsy interviews reporting respiratory symptoms for respiratory-related and other PHMRC causes of death, by age group
Symptom
n 11,984
Respiratory-related causes of deatha
Other causes of death
Adults (n = 1,074)
Children (n = 519)
Neonates (n = 541)
Adults (n = 6,338)
Children (n = 1,449)
Neonates (n = 2,063)
Any breathing problem
7,898
945 (88.0%)
465 (89.6%)
435 (80.4%)
4,260 (67.2%)
906 (62.5%)
887 (43.0%)
Rapid breathing
4,126
578 (53.8%)
320 (61.7%)
122 (22.6%)
2,312 (36.5%)
511 (35.3%)
283 (13.7%)
Breathless on exertion
415
96 (8.9%)
319 (5.0%)
Breathless lying down
1,965
322 (30.0%)
1,643 (25.9%)
Chest indrawing
987
270 (52.0%)
101 (18.7%)
349 (24.1%)
267 (12.9%)
Wheezing or grunting
2,188
323 (30.0%)
240 (46.2%)
60 (11.1%)
1,018 (16.1%)
340 (23.5%)
207 (10.0%)
aIncludes asthma, birth asphyxia, chronic obstructive pulmonary disease, lung cancer, pneumonia and tuberculosis. PHMRC, Population Health Metrics Research Consortium.
CSMFs are shown in Table 4 by age group and for all ages combined for 43 cause-of-death categories as determined by InterVA-4 and PHMRC. Differences in CSMF and 95% confidence intervals (CIs) of those differences are shown for the all-age CSMFs. For 22/43 causes (51.1%), CSMF differences were less than 1%. Figure 2 illustrates the correlation between PHMRC and InterVA-4 CSMFs in the 11,984 cases and 43 cause categories analyzed. The concordance correlation coefficient was 0.612 (95% CI 0.454 to 0.770). Excluding the residual categories, the concordance correlation coefficient increased to 0.665 (95% CI 0.502 to 0.827).
Table 4
Cause-specific mortality fractions (%) for 11,984 deaths by age group and for all ages as determined by InterVA-4 and PHMRC hospital causes of death
Cause of death category
Adults
Children
Neonates
Stillbirths
All ages
InterVA
PHMRC
InterVA
PHMRC
InterVA
PHMRC
InterVA
PHMRC
InterVA
PHMRC
diff
95% CI
01.01 Sepsis (non-obstetric)
0.13
0.4
6.35
0.15
1.04
−0.89
−1.09 to −0.70
01.02 Acute resp infect, incl pneumonia
14.97
7.07
43.78
26.37
16.45
8.70
7.74
6.91 to 8.58
01.03 HIV/AIDS related death
6.57
6.44
6.34
0.91
5.11
4.13
0.97
0.44 to 1.51
01.04 Diarrheal diseases
0.17
2.98
3.78
12.7
0.73
3.93
−3.20
−3.58 to −2.82
01.05 Malaria
1.8
1.23
11.68
5.59
3.03
1.68
1.35
0.97 to 1.74
01.06 Measles
0.03
0.64
1.17
0.12
0.19
−0.07
−0.17 to 0.03
01.07 Meningitis and encephalitis
0.76
1.73
4.93
0.82
0.81
0.01
−0.22 to 0.23
01.09 Pulmonary tuberculosis
5.64
3.33
0.24
3.53
2.06
1.47
1.05 to 1.89
01.11 Hemorrhagic fever
0.27
2.54
0.04
0.42
−0.37
−0.49 to −0.25
01.99 Other and unspecified infect dis
1.89
3.35
1.33
3.4
1.39
2.63
−1.24
−1.60 to −0.89
02.02 Digestive neoplasms
3.2
2.51
1.98
1.55
0.43
0.09 to 0.76
02.03 Respiratory neoplasms
0.94
1.38
0.58
0.85
−0.27
−0.48 to −0.06
02.04 Breast neoplasms
1.59
2.54
0.99
1.57
−0.58
−0.87 to −0.30
02.05, 02.06 Reproductive neoplasms M,F
2.55
2.54
1.58
1.57
0.01
−0.31 to 0.32
02.99 Other and unspecified neoplasms
1.78
1.98
1.37
1.10
1.45
−0.35
−0.63 to −0.07
03.03 Diabetes mellitus
1.88
5.19
0.03
1.17
3.21
−2.05
−2.41 to −1.68
04.01 Acute cardiac disease
1.55
5.06
0.96
3.13
−2.17
−2.52 to −1.81
04.02 Stroke
4.93
7.8
3.05
4.82
−1.77
−2.27 to −1.28
04.99 Other and unspecified cardiac dis
12.75
5.38
0.03
3.81
7.89
3.96
3.94
3.34 to 4.53
05.01 Chronic obstructive pulmonary dis
1.87
2.15
1.16
1.33
−0.17
−0.45 to 0.11
05.02 Asthma
1.5
0.57
0.22
0.96
0.35
0.61
0.41 to 0.81
06.02 Liver cirrhosis
1.33
3.93
0.82
2.43
−1.61
−1.92 to −1.29
07.01 Renal failure
0.83
5.4
0.52
3.34
−2.82
−3.17 to −2.48
08.01 Epilepsy
0.87
0.59
0.37
0.60
0.37
0.23
0.06 to 0.41
98 Other and unspecified NCD
12.13
7.61
5.59
2.34
8.42
5.09
3.33
2.69 to 3.96
09 Maternal CoD
2.57
6.22
1.59
3.85
−2.26
−2.67 to −1.85
10.01 Prematurity
7.99
40.8
0.85
1.14
5.46
−4.32
−4.77 to −3.87
10.02 Birth asphyxia
31.46
28.57
3.79
4.52
3.82
0.70
0.20 to 1.21
10.03 Neonatal pneumonia
38.47
5.18
0.54
5.19
0.69
4.50
4.08 to 4.92
10.04 Neonatal sepsis
5.03
10.23
0.18
0.63
1.37
−0.74
−0.99 to −0.49
10.06 Congenital malformation
1.45
15.22
0.68
0.25
2.04
−1.78
−2.05 to −1.52
10.99 Other and unspecified neonatal CoD
2.77
1.33
0.48
0.00
0.48
0.35 to 0.60
11 Stillbirth
5.62
76.94
100
7.18
8.35
−1.17
−1.85 to −0.50
12.01 Road traffic accident
1.51
2.6
3.68
4.57
1.54
2.36
−0.82
−1.17 to −0.47
12.03 Accid fall
0.7
2.17
1.41
2.18
0.66
1.70
−1.04
−1.31 to −0.77
12.04 Accid drowning and submersion
0.57
1.39
3.55
3.96
0.94
1.51
−0.57
−0.85 to −0.30
12.05 Accid expos to smoke, fire & flame
0.37
1.59
1.54
3.25
0.48
1.52
−1.04
−1.29 to −0.79
12.06 Contact with venomous plant/animal
0.55
0.84
2.31
2.59
0.72
0.94
−0.22
−0.45 to 0.01
12.07 Accid poisoning and noxious subs
0.04
1.11
0.33
0.91
0.08
0.83
−0.75
−0.92 to −0.58
12.08 Intentional self-harm
2.01
1.61
0.03
1.25
0.99
0.26
−0.01 to 0.52
12.09 Assault
2.27
2.2
3.3
2.49
1.94
1.77
0.18
−0.17 to 0.52
12.99 Other and unspecified external CoD
0.02
1.27
0.12
0.03
0.78
−0.75
−0.92 to −0.59
99 Indeterminate
7.71
7.31
8.54
7.21
15.69
8.24
1.40
6.84
6.31 to 7.38
CI, confidence interval; PHMRC, Population Health Metrics Research Consortium.
×
Anzeige
In an empirical comparison of the DHS 2010 Afghanistan dataset (3,349 deaths) run through InterVA-4 with and without the input indicators not available in the PHMRC dataset, overall 16.2% of causes of death were re-assigned due to the missing indicators. There was a net shift of 2.5% of all deaths into residual categories. Specific causes which increased most appreciably due to the missing indicators included neonatal pneumonia, acute abdomen and asthma, while the greatest decreases due to the missing indicators were seen in birth asphyxia, COPD and diarrheal diseases. However, the top six ranked causes of death were the same in both cases.
Discussion
The PHMRC VA dataset undoubtedly represents an important attempt to collect a set of reference data for VA that have corresponding causes of death established in high-level facilities offering good diagnostic procedures. Obviously, since the commencement of the PHMRC study preceded the WHO 2012 VA standard, the dataset could not correspond directly to that standard. In the analyses presented here, equivalence between the PHMRC and WHO 2012 VA cause of death categories and VA indicators has been established as transparently and completely as possible, given the inherent differences. Empirical findings from the Afghan data comparison suggest that the WHO 2012 indicators which are missing from the PHMRC dataset may have some effect in terms of decreased certainty of cause attribution and redistribution of certain causes, although the overall cause of death profile may not change markedly in consequence. The relatively robust nature of the InterVA model has also been demonstrated in a previous sensitivity analysis [17].
Nevertheless, there are some differences both of principle and detail that cannot be totally reconciled between the PHMRC and WHO 2012 approaches. The PHMRC study set out to rigorously define causes of death, but this involved imposing some hierarchies which may not be universally recognized and are not always consistent with ICD-10 coding. For example, prematurity as cause of death can be applied according to the PHMRC definitions if a baby is born at <33 weeks gestational age and experienced ‘death from another medically documented neonatal condition’ irrespective of that condition [7]. This differs appreciably from ICD-10 coding: ‘The mode of death, e.g. heart failure, asphyxia or anoxia, should not be entered… [as the most important cause] …unless it was the only fetal or infant condition known. This also holds true for prematurity’. [18]. As can be seen from the PHMRC causes of death in Figure 1, prematurity is consequently the dominant component of mortality throughout the neonatal period. InterVA-4, on the other hand, ascribes more of these later neonatal deaths among premature babies to infectious causes, based on their subsequently reported symptoms. Neither of these two approaches is necessarily right or wrong, and both may actually be different views of the same reality; but the differences are very important in statistical descriptions of neonatal mortality and in assessing the comparability of different methods of cause of death ascertainment.
Unfortunately, the PHMRC public-domain dataset does not include any clinical details from the hospital work-ups in addition to the assigned cause of death. It would add considerable value to have basic clinical parameters for these deaths irrespective of cause of death. As has been shown in a multicenter analysis of VA cause of death against HIV serostatus, being infected with HIV has consequences for cause of death far beyond the number of classic AIDS deaths [19], and this may also be true for other factors routinely recorded as clinical parameters, such as malaria parasitemia, hemoglobin levels, and so on. It would also be of interest to have included the PHMRC local physicians’ interpretation of the VAs in order to see how those related to VA data, even though the PHMRC group previously concluded that physicians did not perform particularly well against the hospital causes of death [20].
Anzeige
The very high proportion of VA interviews reporting respiratory symptoms in the PHMRC dataset is also worth noting. Table 3 shows rather non-specific relationships between respiratory symptoms and respiratory causes of death in the PHMRC data, which need further investigation and explanation. One possibility is that many patients in tertiary facilities may receive oxygen therapy in the final stages of an illness leading to death, which may be interpreted as respiratory difficulties by family and friends when later responding to a VA interview. In any case, the high proportion of VAs reporting respiratory symptoms leads InterVA-4 to assign high fractions of respiratory-related causes of death. Again, further clinical details in terms of treatment received in the final illness would add value to the utility of the PHMRC dataset. By extension, this and similar issues also raise questions of the validity of using tertiary facility deaths as the evidence base for VA methods. For example, since all the injury cases in the PHMRC data were hospitalized, clearly none of them could have been instantaneous or near-instantaneous fatalities. On closer examination, many of the VAs for injury cases also reported a range of symptoms not obviously associated with their injuries by the time they died in hospital; but, according to the PHMRC protocols, any ‘third-party written account’ of an injury makes that injury the cause of death, irrespective of further clinical details [7].
There are some significant omissions in the PHMRC indicators compared with the WHO 2012 standard. Many of the detailed items relating to obstetric causes of death were missing from the PHMRC instrument, for example. Other items were recorded more precisely by PHMRC, such as details around loss of consciousness and tobacco consumption. Inevitably the comparability of cause of death between the PHMRC cause categories and the WHO 2012 VA cause categories generated by InterVA-4 are somewhat compromised by the differences in cause definitions and by missing 30% of the WHO 2012 VA indicators. Given these sources of variation, the overall concordance correlation coefficient of 0.6, as reflected in Figure 2 for specific cause categories, reflected reasonably good agreement. Some particular cause categories, such as pneumonia, some neonatal causes and certain residual groupings, accounted for much of the non-concordance.
Unsurprisingly, there were cases within the PHMRC database which showed blatant inconsistencies between hospital cause of death and responses to some VA questions. The most obvious were the 147 cases recorded as stillbirths in hospital but which were described as neonatal deaths in VA interviews, and the 90 hospital maternal deaths described as neither pregnant nor recently delivered in VA interviews. There is no way of knowing from the dataset whether these reflected data quality issues either in the hospital causes of death or VA material, or whether VA respondents were actually, either knowingly or unwittingly, presenting a different picture. It is, of course, likely that there were similar phenomena relating to other parameters which cannot be so easily checked. However, it raises an important issue if such a dataset is to be used to build an evidence-based model for VA interpretation, because any data-driven model based solely on these data would ‘learn’, for example, that a proportion of stillbirths show signs of life and that a proportion of maternal deaths occur in non-pregnant women. These effects are of particular concern in the case of, for example, the random forest and tariff models which the PHMRC group has built exclusively from this dataset and then evaluated using the same data [2, 3]. Earlier work with artificial neural networks showed that VA models could be built with extremely high internal validity but had very limited external validity [21]. PHMRC’s earlier conclusions that independent methods (physician interpretation [20] and InterVA-3 [22]) performed less well against the PHMRC dataset than their internally-derived methods essentially confirm that the internal and external validities of automated VA methods can be very different. These findings are also reflected in a systematic review of automated VA methods [23]. There may be an argument for an expert panel to censor unreliable or contradictory cases from any VA reference database before using it to build VA models, in order to improve external validity. In addition, including residual cause of death categories in data for building models is unlikely to be very productive, given that residual categories are likely to include multifarious symptomatology, with no clear mapping between symptoms and cause of death categories.
Conclusions
The PHMRC VA dataset is a unique resource in terms of offering mappings from causes of death determined in tertiary hospitals to corresponding VA data. The dataset would be all the more valuable if it included clinical diagnostic data, details of hospital treatment and local physicians’ interpretation of the VA material. In addition, a more usable presentation of terms included in the VA narratives might add further insights.
Anzeige
Such a dataset basically has two potential uses in relation to VA methods in general. Firstly, it is potentially a source of reference VA data which can be used to evaluate various approaches intended for interpreting other VA material, basically as done here in Figure 2. When used in that way, it should not be applied to data-driven models that have themselves been built from this same reference dataset to avoid confusion between the internal and external validity of models. Secondly, it is potentially a source of evidence between established causes of death and VA data that can be used to build evidence-based models for interpreting other VA data. Used in this context, it would be important to censor obviously misleading cases and probably also to exclude residual cause of death categories before extracting evidence from the dataset into models. In both uses, it is impossible to completely discount the effect of taking only tertiary hospital cases and cause of death assignments, which clearly differ in some important respects from more usual all-population applications of VA. Nevertheless, this effect has to be weighed against the advantages of having hospital causes of death based on sound clinical evidence.
It would still be very interesting to see studies of all-population post-mortem series from settings in low- and middle-income countries in order to build a more definitive evidence base from which to construct and validate VA methods [24].
Acknowledgments
This work was undertaken within the Umeå Centre for Global Health Research, with support from Forte, the Swedish Research Council for Health, Working Life and Welfare (grant no. 2006–1512). Thanks are due to the Population Health Metrics Research Consortium for making their VA dataset available in the public domain, and to Measure DHS for making available the VA dataset from the Afghanistan 2010 national mortality survey.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Competing interests
The author declares that he has no competing interests, and points out that the InterVA models which he has developed are entirely public domain assets.
Dass sich invasive Pilzinfektionen in letzter Zeit weltweit häufen, liegt wahrscheinlich auch am Klimawandel. Ausbrüche mit dem Hefepilz Candida auris stellen eine zunehmende Gefahr für Immungeschwächte dar – auch in Deutschland.
Darmkrebserkrankungen in jüngeren Jahren sind ein zunehmendes Problem, das häufig längere Zeit übersehen wird, gerade weil die Patienten noch nicht alt sind. Welche Anzeichen Ärzte stutzig machen sollten, hat eine Metaanalyse herausgearbeitet.
Bei chronischer Verstopfung wirken Kiwis offenbar besser als Flohsamenschalen. Das zeigen die Daten aus einer randomisierten Studie, die der Gastroenterologe Oliver Pech beim Praxis-Update vorstellte.
Im Verlauf von rheumatoider Arthritis entwickeln viele Patienten extraartikuläre Manifestationen. Schwedische Forscher haben sich mit der Inzidenz und den Risikofaktoren befasst.
Update Allgemeinmedizin
Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.