Introduction
Materials and methods
Patients and controls
Detection of mannose-binding lectin gene polymorphisms
Statistical analysis
Results
Findings in healthy controls
Healthy control, n (%) | Hong Kong controla, n (%) | European controlb, n (%) | |
---|---|---|---|
Wide type | 36 (75.0) | 153 (78.1) | 84 (73.7) |
Heterozygous type | 12 (25.0) | 42 (21.4) | 28 (24.6) |
Homozygous type | 0 (0.0) | 1 (0.5) | 2 (1.7) |
Frequency of allele A | 0.12 | 0.11 | 0.14 |
Findings in patients with juvenile idiopathic arthritis
Groups | Genotype | Allele | HWE P value | |||
---|---|---|---|---|---|---|
Wild type | Heterozygous type | Homozygous type | G | A | ||
JIA, n (%) | 66 (71.0) | 24 (25.8) | 3 (3.2) | 0.84 | 0.16 | 0.66 |
Control, n (%) | 36 (75.0) | 12 (25.0) | 0 (0.0) | 0.88 | 0.12 | 0.32 |
P
| 0.69a | 0.42b |
Codon 54 mutations in subgroups of patients with juvenile idiopathic arthritis
Subtype of JIA | Genotype | Allele | |||
---|---|---|---|---|---|
Wild type | Heterozygous type | Homozygous type | G | A | |
Systemic onset, n (%) | 18 (69.2) | 6 (23.1) | 2 (7.7) | 0.808 | 0.192 |
RF(-) polyarthritis, n (%) | 17 (73.9) | 6 (26.1) | 0 (0.0) | 0.870 | 0.130 |
RF(+) polyarthritis, n (%) | 9 (60.0) | 5 (33.3) | 1 (6.7) | 0.767 | 0.233 |
Oligoarthritis, n (%) | 13 (81.2) | 3 (18.8) | 0 (0.0) | 0.906 | 0.094 |
ERA, n (%) | 9 (69.2) | 4 (30.8) | 0 (0.0) | 0.846 | 0.154 |
P value | 0.84a | 0.57b |
Analysis of the genotype of codon 54 and serum indices in patients with juvenile idiopathic arthritis
Indices | JIA genotype (n = 93) | P value | ||
---|---|---|---|---|
Wild type (n = 66) | Mutation type (n = 27) | |||
RF | positive (n = 15) negative (n = 78) | 9 57 | 6 21 | 0.36 |
ANA | positive (n = 16) negative (n = 77) | 11 55 | 5 22 | 1.00 |