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Arthritis Research & Therapy
Erschienen in: Arthritis Research & Therapy 3/2008

01.06.2008 | Review

High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease

verfasst von: David S Pisetsky, Helena Erlandsson-Harris, Ulf Andersson

Erschienen in: Arthritis Research & Therapy | Ausgabe 3/2008

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Abstract

High-mobility group box protein 1 (HMGB1) is a non-histone nuclear protein that has a dual function. Inside the cell, HMGB1 binds DNA, regulating transcription and determining chromosomal architecture. Outside the cell, HMGB1 can serve as an alarmin to activate the innate system and mediate a wide range of physiological and pathological responses. To function as an alarmin, HMGB1 translocates from the nucleus of the cell to the extra-cellular milieu, a process that can take place with cell activation as well as cell death. HMGB1 can interact with receptors that include RAGE (receptor for advanced glycation endproducts) as well as Toll-like receptor-2 (TLR-2) and TLR-4 and function in a synergistic fashion with other proinflammatory mediators to induce responses. As shown in studies on patients as well as animal models, HMGB1 can play an important role in the pathogenesis of rheumatic disease, including rheumatoid arthritis, systemic lupus erythematosus, and polymyositis among others. New approaches to therapy for these diseases may involve strategies to inhibit HMGB1 release from cells, its interaction with receptors, and downstream signaling.
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Metadaten
Titel
High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease
verfasst von
David S Pisetsky
Helena Erlandsson-Harris
Ulf Andersson
Publikationsdatum
01.06.2008
Verlag
BioMed Central
Erschienen in
Arthritis Research & Therapy / Ausgabe 3/2008
Elektronische ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar2440

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29.05.2024 Herzinfarkt Nachrichten

Bei Menschen mit Typ-2-Diabetes sind die Chancen, einen Myokardinfarkt zu überleben, in den letzten 15 Jahren deutlich gestiegen – nicht jedoch bei Betroffenen mit Typ 1.

15% bedauern gewählte Blasenkrebs-Therapie

29.05.2024 Urothelkarzinom Nachrichten

Ob Patienten und Patientinnen mit neu diagnostiziertem Blasenkrebs ein Jahr später Bedauern über die Therapieentscheidung empfinden, wird einer Studie aus England zufolge von der Radikalität und dem Erfolg des Eingriffs beeinflusst.

Costims – das nächste heiße Ding in der Krebstherapie?

28.05.2024 Onkologische Immuntherapie Nachrichten

„Kalte“ Tumoren werden heiß – CD28-kostimulatorische Antikörper sollen dies ermöglichen. Am besten könnten diese in Kombination mit BiTEs und Checkpointhemmern wirken. Erste klinische Studien laufen bereits.

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