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Arthritis Research & Therapy

Erschienen in:

01.06.2010 | Review

New developments in osteoarthritis: Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options

verfasst von: Martin K Lotz

Erschienen in: Arthritis Research & Therapy | Ausgabe 3/2010

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Abstract

Joint trauma can lead to a spectrum of acute lesions, including osteochondral fractures, ligament or meniscus tears and damage to the articular cartilage. This is often associated with intraarticular bleeding and causes posttraumatic joint inflammation. Although the acute symptoms resolve and some of the lesions can be surgically repaired, joint injury triggers a chronic remodeling process in cartilage and other joint tissues that ultimately manifests as osteoarthritis in a majority of cases. The objective of the present review is to summarize information on pathogenetic mechanisms involved in the acute and chronic consequences of joint trauma and discuss potential pharmacological interventions. The focus of the review is on the early events that follow joint trauma since therapies for posttraumatic joint inflammation are not available and this represents a unique window of opportunity to limit chronic consequences.

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Titel: New developments in osteoarthritis: Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options
verfasst von: Martin K Lotz
Publikationsdatum: 01.06.2010
Verlag: BioMed Central
Erschienen in: Arthritis Research & Therapy / Ausgabe 3/2010
Elektronische ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar3046

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Der Tyrosinkinasehemmer (TKI) Asciminib ist älteren Vertretern dieser Gruppe bei CML offenbar überlegen: Personen mit frisch diagnostizierter CML entwickelten damit in einer Phase-3-Studie häufiger eine gut molekulare Response, aber seltener ernste Nebenwirkungen.

Hereditäres Angioödem: Tablette könnte Akuttherapie erleichtern

05.06.2024 Hereditäres Angioödem Nachrichten

Medikamente zur Bedarfstherapie bei hereditärem Angioödem sind bisher nur als Injektionen und Infusionen verfügbar. Der Arzneistoff Sebetralstat kann oral verabreicht werden und liefert vielversprechende Daten.

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