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Breast Cancer Research

Erschienen in:

01.10.2001 | Review

Hypoxia and oxidative stress in breast cancer Oxidative stress - its effects on the growth, metastatic potential and response to therapy of breast cancer

verfasst von: Nicholas S Brown, Roy Bicknell

Erschienen in: Breast Cancer Research | Ausgabe 5/2001

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Abstract

Reactive oxygen species (ROS) damage DNA, but the role of ROS in breast carcinoma may not be limited to the mutagenic activity that drives carcinoma initiation and progression. Carcinoma cells in vitro and in vivo are frequently under persistent oxidative stress. In the present review, we outline potential causes of oxygen radical generation within carcinoma cells and explore the possible impact of oxidative stress on the clinical outcome of breast carcinoma.

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Titel: Hypoxia and oxidative stress in breast cancer Oxidative stress - its effects on the growth, metastatic potential and response to therapy of breast cancer
verfasst von: Nicholas S Brown
Roy Bicknell
Publikationsdatum: 01.10.2001
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe 5/2001
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr315

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