Background
The obesity pandemic
Methods
Study design
BMI data - GIANT
Heart attack data - UK biobank
Summary data
Statistical analysis
Results
Higher BMI causes increased risk of heart attacks in European descendants
SNP | Chr | Position | EA | OA | EAF | Beta | SE | P | Gene |
---|---|---|---|---|---|---|---|---|---|
rs1343424 | 1 | 49,376,820 | C | T | 0.251 | 0.02 | 0.004 | 8.56E-09 | AGBL4 |
rs2422134 | 1 | 72,514,701 | C | G | 0.508 | −0.022 | 0.003 | 2.49E-13 | NEGR1 |
rs6690871 | 1 | 74,977,277 | G | A | 0.407 | 0.022 | 0.003 | 1.28E-12 | LRRC53 |
rs505066 | 1 | 96,882,671 | A | C | 0.285 | 0.025 | 0.004 | 2.35E-09 | (UBE2WP1) |
rs7550711 | 1 | 110,082,886 | T | C | 0.026 | 0.066 | 0.009 | 9.51E-14 | GPR61 |
rs4478775 | 1 | 177,770,097 | A | G | 0.223 | 0.025 | 0.004 | 1.98E-11 | SEC16B |
rs2820292 | 1 | 201,784,287 | A | C | 0.432 | −0.02 | 0.003 | 1.58E-10 | NAV1 |
rs13411762 | 2 | 554,109 | C | T | 0.928 | 0.033 | 0.006 | 5.93E-09 | (TMEM18) |
rs13391869 | 2 | 606,213 | G | A | 0.848 | −0.022 | 0.004 | 1.65E-08 | (TMEM18) |
rs10495749 | 2 | 24,730,847 | A | G | 0.231 | −0.021 | 0.004 | 3.21E-09 | NCOA1 |
rs11126666 | 2 | 26,928,811 | G | A | 0.745 | −0.021 | 0.003 | 5.71E-10 | KCNK3 |
rs13011109 | 2 | 58,857,419 | G | C | 0.612 | 0.018 | 0.003 | 6.84E-09 | FANCL |
rs6545714 | 2 | 59,307,725 | G | A | 0.399 | 0.018 | 0.003 | 3.19E-09 | (FANCL) |
rs2890652 | 2 | 142,959,931 | T | C | 0.839 | −0.028 | 0.005 | 2.24E-08 | (LRP1B) |
rs1528435 | 2 | 181,550,962 | T | C | 0.62 | 0.018 | 0.003 | 4.68E-09 | (UBE2E3) |
rs7599312 | 2 | 213,413,231 | G | A | 0.732 | 0.022 | 0.003 | 4.88E-11 | (ERBB4) |
rs10510554 | 3 | 25,099,776 | T | C | 0.431 | −0.018 | 0.003 | 1.78E-09 | RARB |
rs1916801 | 3 | 61,187,046 | A | T | 0.595 | 0.019 | 0.003 | 8.13E-10 | FHIT |
rs3849570 | 3 | 81,792,112 | A | C | 0.348 | 0.019 | 0.003 | 1.61E-08 | GBE1 |
rs10511073 | 3 | 85,653,460 | G | A | 0.646 | −0.021 | 0.003 | 1.46E-10 | CADM2 |
rs16851483 | 3 | 141,275,436 | G | T | 0.934 | −0.048 | 0.008 | 1.77E-10 | RASA2 |
rs4494964 | 3 | 185,776,491 | T | C | 0.142 | −0.04 | 0.005 | 1.39E-15 | ETV5 |
rs13144044 | 4 | 45,082,236 | C | G | 0.534 | −0.025 | 0.004 | 1.02E-11 | (GNPDA2) |
rs17001654 | 4 | 77,129,568 | C | G | 0.852 | −0.031 | 0.005 | 3.88E-09 | SCARB2 |
rs13107325 | 4 | 103,188,709 | C | T | 0.925 | −0.048 | 0.007 | 1.15E-12 | SLC39A8 |
rs11727676 | 4 | 145,659,064 | C | T | 0.096 | −0.036 | 0.006 | 1.11E-08 | HHIP |
rs6871667 | 5 | 74,604,742 | A | G | 0.401 | −0.017 | 0.003 | 1.44E-08 | (HMGCR) |
rs280275 | 6 | 50,668,612 | A | G | 0.952 | −0.039 | 0.007 | 4.46E-09 | (TFAP2D) |
rs4141973 | 6 | 50,946,521 | T | C | 0.134 | 0.028 | 0.005 | 5.51E-09 | (FTH1P5) |
rs9400239 | 6 | 108,977,663 | C | T | 0.706 | 0.019 | 0.003 | 6.10E-09 | FOXO3 |
rs13191362 | 6 | 163,033,350 | A | G | 0.875 | 0.028 | 0.005 | 3.94E-09 | PARK2 |
rs1167827 | 7 | 75,163,169 | A | G | 0.435 | −0.02 | 0.003 | 4.64E-10 | HIP1 |
rs2245368 | 7 | 76,608,143 | T | C | 0.833 | −0.032 | 0.006 | 1.34E-08 | DTX2P1 |
rs2922763 | 8 | 76,573,711 | G | T | 0.274 | −0.024 | 0.004 | 2.73E-10 | (HNF4G) |
rs2033732 | 8 | 85,079,709 | C | T | 0.744 | 0.019 | 0.004 | 2.06E-08 | (RALYL) |
rs4740619 | 9 | 15,634,326 | T | C | 0.551 | 0.018 | 0.003 | 3.87E-09 | CCDC171 |
rs1412234 | 9 | 28,410,683 | C | T | 0.33 | 0.024 | 0.004 | 4.97E-09 | LINGO2 |
rs6477694 | 9 | 111,932,342 | C | T | 0.354 | 0.017 | 0.003 | 9.95E-09 | (FRRS1L) |
rs1928295 | 9 | 120,378,483 | C | T | 0.43 | −0.019 | 0.003 | 6.62E-10 | (TLR4) |
rs10733682 | 9 | 129,460,914 | A | G | 0.473 | 0.017 | 0.003 | 9.95E-09 | LMX1B |
rs7899106 | 10 | 87,410,904 | A | G | 0.95 | −0.04 | 0.007 | 1.32E-08 | GRID1 |
rs17094222 | 10 | 102,395,440 | C | T | 0.213 | 0.025 | 0.004 | 2.83E-11 | (PAX2) |
rs17747324 | 10 | 114,752,503 | C | T | 0.227 | −0.023 | 0.004 | 1.16E-09 | TCF7L2 |
rs1374262 | 11 | 8,458,749 | G | A | 0.532 | 0.017 | 0.003 | 1.44E-08 | STK33 |
rs4514364 | 11 | 27,456,059 | C | T | 0.316 | 0.02 | 0.003 | 1.72E-09 | LGR4 |
rs2176598 | 11 | 43,864,278 | T | C | 0.246 | 0.02 | 0.004 | 1.90E-08 | HSD17B12 |
rs2856650 | 11 | 47,365,199 | G | A | 0.703 | −0.02 | 0.003 | 9.87E-10 | MYBPC3 |
rs12286929 | 11 | 115,022,404 | G | A | 0.527 | 0.022 | 0.003 | 1.28E-12 | (CADM1) |
rs2720296 | 12 | 50,169,070 | G | A | 0.613 | −0.02 | 0.003 | 9.87E-10 | (LSM6P2) |
rs11057405 | 12 | 122,781,897 | A | G | 0.106 | −0.031 | 0.006 | 1.19E-08 | CLIP1 |
rs7988412 | 13 | 28,000,282 | C | T | 0.815 | −0.026 | 0.005 | 1.10E-08 | GTF3A |
rs2797084 | 13 | 54,071,824 | T | C | 0.86 | − 0.032 | 0.006 | 6.12E-09 | (OLFM4) |
rs10132280 | 14 | 25,928,179 | A | C | 0.3 | −0.023 | 0.003 | 6.68E-12 | (STXBP6) |
rs2370982 | 14 | 79,890,677 | T | C | 0.216 | 0.025 | 0.005 | 2.43E-08 | NRXN3 |
rs3736485 | 15 | 51,748,610 | A | G | 0.461 | 0.018 | 0.003 | 6.84E-09 | DMXL2 |
rs12905371 | 15 | 67,845,930 | C | T | 0.736 | 0.021 | 0.004 | 4.46E-09 | MAP 2 K5 |
rs12448257 | 16 | 3,599,655 | G | A | 0.784 | −0.024 | 0.004 | 8.42E-10 | NLRC3 |
rs2531995 | 16 | 4,013,467 | C | T | 0.379 | −0.024 | 0.004 | 8.46E-10 | ADCY9 |
rs2354584 | 16 | 19,778,575 | A | G | 0.87 | 0.035 | 0.006 | 1.10E-09 | IQCK |
rs2650492 | 16 | 28,333,411 | A | G | 0.298 | 0.021 | 0.004 | 1.67E-09 | SBK1 |
rs2303222 | 16 | 31,085,470 | C | T | 0.378 | −0.018 | 0.003 | 1.78E-09 | ZNF668 |
rs1477199 | 16 | 53,712,135 | A | G | 0.864 | −0.024 | 0.004 | 1.90E-08 | RPGRIP1L |
rs7205986 | 16 | 53,755,146 | G | A | 0.511 | 0.025 | 0.003 | 3.68E-16 | FTO |
rs3026101 | 17 | 5,280,440 | C | T | 0.301 | 0.018 | 0.003 | 1.23E-08 | NUP88 |
rs12949279 | 17 | 78,558,411 | C | T | 0.439 | −0.018 | 0.003 | 8.25E-09 | RPTOR |
rs891389 | 18 | 21,087,531 | C | T | 0.655 | −0.021 | 0.004 | 2.20E-08 | RMC1 |
rs7243357 | 18 | 56,883,319 | G | T | 0.176 | −0.022 | 0.004 | 2.90E-08 | (GRP) |
rs4940929 | 18 | 57,803,890 | G | C | 0.583 | 0.027 | 0.004 | 3.43E-11 | (MC4R) |
rs9944545 | 18 | 57,958,244 | T | C | 0.297 | 0.034 | 0.003 | 5.66E-24 | (MC4R) |
rs17724992 | 19 | 18,454,825 | A | G | 0.733 | 0.019 | 0.004 | 1.49E-08 | PGPEP1 |
rs29944 | 19 | 34,306,898 | A | G | 0.327 | −0.018 | 0.003 | 2.07E-08 | (KCTD15) |
rs2075650 | 19 | 45,395,619 | A | G | 0.854 | 0.026 | 0.005 | 4.92E-09 | TOMM40 |
rs9304665 | 19 | 47,602,577 | A | T | 0.765 | 0.025 | 0.004 | 7.61E-09 | ZC3H4 |
MR Method | Estimated OR | 95% CI | P-value |
---|---|---|---|
IVW | 1.008 | (1.003, 1.012) | 0.001 |
RAPS | 1.007 | (1.002, 1.012) | 0.004 |