Background
Methods
Study selection and inclusion criteria
Quality assessment, data extraction, analysis and reporting
Results
Author | Year | Population | Tool | Timing | Variables | AUC (SE) |
---|---|---|---|---|---|---|
Mortality prediction tools | ||||||
Alsina [24] | 2014 | Supratentorial ICH not submitted to surgery | Equation | 30 days | IVH, hematoma size, and midline shift. | 0·933 (0·029) |
Berwaerts [41] | 2000 | Oral anticoagulant related ICH | Equation | Discharge | Hematoma diameter and CT signs of ischemia. | – |
Bhatia [65] | 2013 | Primary ICH | Equation | Discharge | GCS, hematoma size, IVH,and ventilatory requirement. | 0·822 (0·033) |
Broderick [44] | 1993 | Spontaneous ICH | Equation | 30 days | GCS, hematoma size. | 0·805 (0·036) |
Broderick´ [44] | 1993 | Spontaneous ICH | Equation | 30 days | Hematoma size, IVH volume, GCS, and surgery. | – |
Celik [68] | 2014 | Spontaneous ICH | ANN | 10 days | Age, gender, hypertension, diabetes, smoking, mean blood pressure, Scandinavian Stroke Scale score, pulse pressure, localization of hemorrhage (including infratentorial), volume of hemorrhage, ventricular drainage, and midline shift. | – |
Cerillo [21] | 1981 | Operated supratentorial ICH | Equation | Discharge | Age, mode of onset, site of hemorrhage, level of consciousness, time from onset to surgery, congestive heart failure/coronary artery disease, and diabetes/uremia. | 0·893 (0·033) |
Chen [45] | 2011 | Nontraumatic ICH | Score | Discharge | GCS, hematoma volume, IVH, and diabetes. | 0·867 (0·027) |
Chiu [61] | 2016 | Spontaneous ICH | CART+SVM | 30 days | GCS, hematoma size. | – |
Chuang [63] | 2009 | Spontaneous ICH | Score | 30 days | Age, GCS, hypertension, glucose and dialysis dependency. | 0·890 (0·026) |
Edwards [28] | 1999 | Supratentorial ICH | ANN | Discharge | Gender, race, hydrocephalus, mean arterial pressure, pulse pressure, GCS, IVH, hematoma size, location (thalamic, basal, lobal), cisternal effacement, pineal shift, hypertension, diabetes, and age. | 0·984 (0·020) |
Edwards´ [28] | 1999 | Supratentorial ICH | Equation | Discharge | Hydrocephalus, GCS, gender, pineal shift | 0·919 (0·043) |
Fogelholm [31] | 1997 | Supratentorial ICH | Equation | 28 days | Consciousness, mean arterial pressure, subarachnoid spread, midline shift, glucose, and vomiting. | – |
Frithz [12] | 1976 | ICH patients < 70 years | Decision tree | Discharge | Consciousness, diastolic blood pressure. | 0·943 (0·024) |
Galbois [38] | 2013 | Spontaneous comatose ICH not submitted to surgery | Score | ICU stay | Brainstem reflexes, swirl sign. | 0·850 (0·050) |
Galbois´ [38] | 2013 | Spontaneous comatose ICH not submitted to surgery | Score | ICU stay | Corneal reflexes, swirl sign. | 0·840 (0·051) |
Grellier [66] | 1983 | Spontaneous ICH | Score | 2 days | Age, gender, consciousness (normal, changed, coma), CV risk factors (alcohol, tobacco, hypertension, dyslipidemia, CV disease), and ICH location (infratentorial, thalamic, internal capsule, oval center, lobar). | – |
Hallevi [34] | 2009 | Primary ICH with IVH | Score | Discharge | GCS, total volume (ICH + IVH). | 0·840a |
Hemphill [48] | 2001 | Nontraumatic ICH | Score | 30 days | Age, ICH volume, infratentorial ICH, GCS, and IVH. | 0·920 (0·020) |
Ho [64] | 2016 | Primary ICH | Score | Discharge | Age, creatinine, NIHSS, heart disease, gender, and systolic blood pressure. | 0·870 (0·018) |
Huang [40] | 2008 | Spontaneous medically treated ICH in hemodialysis patients | Score | 30 days | GCS, age, and systolic blood pressure. | 0·745 (0·048) |
Li [50] | 2012 | Spontaneous ICH | Equation | Discharge | Age, GCS, glucose, and white blood cell count. | 0·923 (0·020) |
Li´ [49] | 2011 | Primary ICH | Score | Discharge | Age, Glucose, LDH, and white blood cell count. | 0·745 (0·025) |
Lukic [33] | 2012 | Primary supratentorial medically treated ICH | Equation | Discharge | Level of consciousness, GCS verbal response, age, gender, and pulse pressure. | 0·856 (0·018) |
Lukic´ [26] | 2012 | Spontaneous supratentorial ICH | ANN | Discharge | Age, gender, pulse pressure, mean arterial pressure, GCS (E/V/M), and consciousness. | 0·883 (0.048) |
Lukic´´ [26] | 2012 | Spontaneous supratentorial ICH | Equation | Discharge | GCS, level of consciousness. | 0·819 (0·030) |
Masé [27] | 1995 | Primary supratentorial medically treated ICH | Equation | 30 days | GCS, IVH spread, and hematoma size. | – |
Parry-Jones [53] | 2013 | Spontaneous ICH | Equation | 30 days | Age, GCS, IVH extension, and hematoma volume. | 0·897 (0·010) |
Peng [54] | 2010 | Spontaneous ICH | Random Forrest | 30 days | Age, gender, hypertension, diabetes, ischemic heart disease, previous stroke, anemia, dialysis dependency, GCS, systolic/diastolic/mean blood pressure, infratentorial bleed, site of ICH, ICH volume, IVH, pineal shift, hydrocephalus, hemoglobin, and glucose. | 0·870 (0·015) |
Peng´ [54] | 2010 | Spontaneous ICH | ANN | 30 days | Age, gender, GCS, site of ICH, ICH volume, IVH, hypertension, diabetes, anemia, and previous stroke. | 0·810 (0·020) |
Peng´´ [54] | 2010 | Spontaneous ICH | SVM | 30 days | Age, gender, GCS, site, ICH volume, IVH, hypertension, diabetes, anemia, and previous stroke. | 0·790 (0·020) |
Peng´´´ [54] | 2010 | Spontaneous ICH | Equation | 30 days | Anemia, age, GCS, hypertension, and dialysis dependency. | 0·780 (0·020) |
Romano [56] | 2009 | Primary ICH | Score | 30 days | GCS, hematoma volume, and intraventricular spread. | 0·915 (0·026) |
Ruiz-Sandoval [58] | 2007 | Primary ICH | Score | Discharge | Age, infratentorial bleed, ICH size, GCS, and IVH spread. | 0·880 (0·017) |
Safatli [60] | 2016 | Primary ICH | Score | 30 days | GCS, infratentorial bleed, and hematoma volume. | – |
Szepesi [32] | 2015 | Supratentorial ICH | Equation | 30 days | Age, hematoma volume, IVH, systolic blood pressure, glucose, and potassium. | – |
Tabak [59] | 2007 | Spontaneous ICH | Equation | Discharge | Age, creatinine, glucose, pH, CO2, O2, partial thromboplastin time, prothrombin time, platelets, white blood cells, cancer, temperature, pulse, systolic blood pressure, respiratory rate, and altered mental status. | 0·890 (0·003) |
Takahashi [67] | 2006 | Spontaneous ICH | CART | Discharge | Japan Coma Scale, ICH volume, and age. | 0·853 (0·024) |
Takahashi´ [67] | 2006 | Spontaneous ICH | Equation | Discharge | Japan Coma Scale, temperature, infratentorial bleed, and ICH volume. | 0·810 (0·033) |
Tshikwela [36] | 2012 | Black hypertensive primary ICH | Score | Discharge | GCS, ICH volume, left hemisphere involved. | – |
Tshikwela´ [36] | 2012 | Black hypertensive primary ICH | Score | Discharge | Gender, GCS, midline shift. | – |
Tuhrim [23] | 1999 | Primary supratentorial ICH managed medically | Equation | 30 days | GCS, ICH volume, pulse pressure, hydrocephalus, and IVH volume. | – |
Tuhrim´ [30] | 1991 | Supratentorial ICH | Equation | 30 days | Hematoma size, IVH, GCS, pulse pressure, and IVHaGCS interaction. | 0·900 (0·027) |
Tuhrim´´ [29] | 1988 | Supratentorial hemorrhage | Equation | 30 days | GCS score, hematoma size, and pulse pressure. | 0·892 (0·042) |
Ziai [35] | 2015 | Primary ICH with IVH | Score | Discharge | Temperature, glucose, intracranial pressure, and Do-Not-Resuscitate orders | 0·850 (0·030) |
Zis [39] | 2014 | Non-operated primary ICH | Score | 30 days | GCS, ICH size, INR, IVH spread, and infratentorial location. | 0·920 (0·023) |
Functional outcome prediction tools | ||||||
Appelboom [10] | 2012 | AVM related ICH | Score | 3 months | Age, IVH, infratentorial bleed, GCS, and hematoma size. | 0·914 (0·039) |
Creutzfeld [47] | 2011 | Primary ICH | Equation | Discharge | Age, GCS, heart rate, mass effect, IVH, premorbid level of function, and systolic blood pressure. | 0·930 (0·014) |
Flemming [18] | 2001 | Lobar primary supratentorial ICH | Tree based model | Discharge | GCS, septum pellucidum shift. | 0·890 (0·045) |
Flemming´ [18] | 2001 | Lobar primary supratentorial ICH | Tree based model | Discharge | ICH size, GCS, and time to presentation. | 0·921 (0·032) |
Hallevy [25] | 2002 | Primary supratentorial medically treated ICH | Score | Discharge | Age, limb paresis, level of consciousness, mass effect, hematoma size, and intraventricular extension. | 0·897 (0·023) |
Ji [51] | 2013 | Spontaneous ICH | Score | 1 year | Age, NIHSS, GCS, glucose, infratentorial bleed, ICH volume, and IVH. | 0·836 (0·009) |
Lisk [22] | 1994 | Primary supratentorial < 24 h | Equation | Discharge or 30 days | Age, GCS, hemorrhage volume, and gender. | – |
Lisk´ [22] | 1994 | Primary supratentorial < 24 h, GCS > 9, no surgery | Equation | Discharge or 30 days | Age, hemorrhage diameter, and ventricular extension. | – |
Neidert [11] | 2016 | AVM related ICH | Score | Unclear | Age, GCS, hematoma size, IVH, AVM size, diffuse nidus, eloquence, and deep venous drainage. | 0·842 (0·046) |
Misra [15] | 1999 | Primary putaminal ICH | Equation | 3 months | GCS, pupillary change, incontinence, and location of hematoma (cortical, subcortical, medial or lateral). | – |
Mittal [52] | 2011 | Primary ICH | Score | Discharge | Age, infratentorial, ICH size, GCS, cognitive impairment, and FOUR score. | – |
Portenoy [20] | 1987 | Nontraumatic supratentorial spontaneous ICH | Equation | Unclear | GCS, ICH size (index), and IVH spread. | – |
Poungvarin [55] | 2006 | Primary ICH | Equation | Discharge | Fever, ICH size > 30, GCS, and IVH spread. | – |
Rost [57] | 2008 | Primary ICH | Score | 3 months | Age, GCS, hematoma size, location (infratentorial/deep/lobar), and cognitive impairment. | 0·879 (0·017) |
Shah [17] | 2005 | Thalamic hemorrhage | Equation | 3 months | Posterolateral ICH extension, Canadian Neurological Scale. | – |
Shaya [19] | 2005 | Hypertensive supratentorial ICH | Score | 6 months | Focal neurological deficit, hydrocephalus, ICH volume | – |
Weimar [42] | 2009 | Patients included in ICH trials | Equation | 3 months | Age, NIHSS, and level of consciousness. | 0·805 (0·020) |
Weimar´ [37] | 2006 | Non-comatose ICH patients | Equation | 100 days | Age, NIHSS. | 0·861 (0·029) |
Weimar´´ [43] | 2006 | Spontaneous ICH | Score | 100 days | Age, NIHSS, and level of consciousness. | 0·913 (0·018) |
Combined outcome prediction tools | ||||||
Cheung [46] | 2003 | Nontraumatic ICH | Score | 30 days | IVH, subarachnoid extension, pulse pressure, NIHSS, and temperature. | – |
– | ||||||
Cheung´ [46] | 2003 | Nontraumatic ICH | Score | 30 days | Age, IVH, infratentorial bleed, NIHSS, and hematoma size. | – |
– | ||||||
Cho [14] | 2008 | Basal ganglia hemorrhage | Score | 6 months | GCS, ICH volume, and IVH. | 0·897 (0·033)b |
Barthel 0·884a GOS 0·935ac | ||||||
Godoy [62] | 2006 | Primary ICH | Score | 30 daysb | Age, GCS, Graeb score, ICH volume, and APACHE2 score comorbidities. | 0·878 (0·028)b |
6 monthsc | 0.893 (0·025)c | |||||
Godoy´ [62] | 2006 | Primary ICH | Score | 30 daysb | Age, GCS, Graeb score, ICH volume, and APACHE2 score comorbidities. | 0·869 (0·029)b |
6 monthsc | 0·895 (0·024)c | |||||
Lei [13] | 2016 | Cerebral amyloid related ICH | Score | 3 months | Age, IVH, midline shift, and GCS. | 0·890 (0·038)b |
0·810 (0·031)c | ||||||
Stein [16] | 2010 | Supratentorial deep ICH with secondary IVH | Score | 30 daysb | Age, GCS, hydrocephalus, and ICH volume | 0·890 (0.036)b |
6 monthsc | 0·848 (0·056)c |
Population, sampling and source of data
Outcome timing, definition and assessment
Number and type of predictors
Author | Source of data | Sampling reported | Nr patients | Nr events | Nr variable | EPV | Loss to follow-up: | Missing data reported? | Blinding reported? | Modelling method | Internal validation | Calibration |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Alsina [24] | Cohort | Not reported | 100 | 38 | 3 | 12.7 | 0% | Yes | No | Logistic | No | Hosmer-Lemeshow |
Berwaerts [41] | Cohort | Consecutive | 42 | 18 | 2 | 9 | 0% | Yes | No | Logistic | No | Not reported |
Bhatia [65] | Cohort | Consecutive | 214 | 70 | 4 | 17.5 | 0% | No | No | Logistic | No | Not reported |
Broderick [44] | Cohort | Consecutive | 162 | 83 | 2 | 19.8 | 0.6% | Yes | No | Logistic | No | Not reported |
Broderick´ [44] | Cohort | Consecutive | 162 | 83 | 4 | 39.5 | 0.6% | Yes | No | Logistic | No | Not reported |
Celik [68] | Cohort | Not reported | 257 | 119 | 12 | 9.9 | 0% | No | No | ANN | Cross-validation | Not reported |
Cerillo [21] | Cohort | Not reported | 88 | 34 | 7 | 4.9 | 0% | No | No | Univariate analysis | No | Not reported |
Chen [45] | Cohort | Consecutive | 285 | 61 | 4 | 15.3 | 0% | No | No | Logistic | No | Not reported |
Chiu [61] | Cohort | Not reported | 106 | 16 | 2 | 8 | 0% | Yes | No | CART + SVM | Split sample | Not reported |
Chuang [63] | Cohort | Not reported | 293 | 40 | 5 | 8 | 0% | No | No | Logistic | Cross-validation | Hosmer-Lemeshow |
Edwards [28] | Cohort | Consecutive | 81 | 21 | 15 | 1.4 | 0% | No | No | ANN | No | Hosmer-Lemeshow |
Edwards´ [28] | Cohort | Consecutive | 81 | 21 | 4 | 5.3 | 0% | Yes | No | Logistic | No | Hosmer-Lemeshow |
Fogelholm [31] | Cohort | Consecutive | 282 | 120 | 6 | 20 | 0% | Yes | No | Logistic | No | Not reported |
Frithz [12] | Cohort | Not reported | 91 | 79 | 2 | 6 | 0% | Yes | No | CART | No | Not reported |
Galbois [38] | Cohort | Consecutive | 72 | 35 | 2 | 17.5 | 0% | Yes | No | Logistic | Cross-validation | Not reported |
Galbois´ [38] | Cohort | Consecutive | 72 | 35 | 2 | 17.5 | 0% | Yes | No | Logistic | Cross-validation | Not reported |
Grellier [66] | Cohort | Not reported | 300 | Not reported | 9 | n/a | 0% | No | No | Unclear | No | Not reported |
Hallevi [34] | Cohort | Consecutive | 174 | Not reported | 2 | n/a | 0% | Yes | No | Logistic | No | Not reported |
Hemphill [48] | Cohort | Consecutive | 152 | 68 | 5 | 13.6 | 0% | Yes | No | Logistic | No | Not reported |
Ho [64] | Registry | Consecutive | 805 | 164 | 6 | 27.3 | 0% | No | No | Logistic | No | Le Cessie and Howelingen + plots |
Huang [40] | Cohort | Consecutive | 107 | 72 | 3 | 11.7 | 0% | Yes | No | Logistic | No | Not reported |
Li [50] | Cohort | Consecutive | 227 | 49 | 4 | 12.3 | 0% | Yes | No | Logistic | No | Not reported |
Li´ [49] | Cohort | Consecutive | 716 | 140 | 4 | 35 | 0% | Yes | No | Logistic | No | Not reported |
Lukic [33] | Cohort | Consecutive | 411 | 256 | 5 | 31 | 0% | Yes | No | Logistic | No | Hosmer-Lemeshow |
Lukic´ [26] | Case-Control | Not reported | 200 | 100 | 8 | 12.5 | 0% | Yes | No | ANN | Split Sample | Not reported |
Lukic´´ [26] | Case-Control | Not reported | 200 | 100 | 2 | 50 | 0% | Yes | No | Logistic | No | Not reported |
Masé [27] | Cohort | Consecutive | 138 | 38 | 3 | 12.7 | 0% | No | No | Logistic | No | Not reported |
Parry-Jones [53] | Cohort | Consecutive | 1175 | 483 | 4 | 120.8 | 1.1% | Yes | No | Logistic | No | Not reported |
Peng [54] | Cohort | Not reported | 423 | 62 | 20 | 3.1 | 0% | Yes | No | Random Forrest | Cross-validation | Not reported |
Peng´ [54] | Cohort | Not reported | 423 | 62 | 10 | 6.2 | 0% | Yes | No | ANN | Cross-validation | Not reported |
Peng´´ [54] | Cohort | Not reported | 423 | 62 | 10 | 12.4 | 0% | Yes | No | SVM | Cross-validation | Not reported |
Peng´´´ [54] | Cohort | Not reported | 423 | 62 | 5 | 12.4 | 0% | Yes | No | Logistic | Cross-validation | Not reported |
Romano [56] | Cohort | Consecutive | 154 | 63 | 3 | 21 | 0.6% | Yes | No | Logistic | Split sample | Not reported |
Ruiz-Sandoval [58] | Cohort | Consecutive | 378 | 174 | 5 | 34.8 | 0% | Yes | No | Logistic | Bootstrap | Hosmer-Lemeshow |
Safatli [60] | Cohort | Consecutive | 342 | 86 | 3 | 28.7 | 0% | No | No | Logistic | No | Hosmer-Lemeshow |
Szepesi [32] | Cohort | Not reported | 125 | 59 | 6 | 9.8 | 0% | Yes | No | Logistic | No | Hosmer-Lemeshow |
Tabak [59] | Administrative data | Consecutive | 29,975 | 6765 | 17 | 397.9 | 0% | Yes | No | Logistic | Bootstrap | Calibration plot |
Takahashi [67] | Cohort | Not reported | 347 | 70 | 3 | 23.3 | 0% | No | No | CART | Cross-validation | Not reported |
Takahashi´ [67] | Cohort | Not reported | 347 | 70 | 4 | 17.5 | 0% | No | No | Logistic | No | Not reported |
Tshikwela [36] | Cohort | Not reported | 185 | 68 | 3 | 22.7 | 0% | No | No | Logistic | No | Not reported |
Tshikwela´ [36] | Cohort | Not reported | 185 | 68 | 3 | 22.7 | 0% | No | No | Logistic | No | Not reported |
Tuhrim [23] | Cohort | Not reported | 129 | 27 | 5 | 5.4 | 0% | No | No | Logistic | No | Not reported |
Tuhrim´ [30] | Registry | Not reported | 187 | 54 | 5 | 10.8 | 2.1% | Yes | No | Logistic | No | Not reported |
Tuhrim´´ [29] | Registry | Not reported | 73 | 25 | 3 | 8.3 | 0% | Yes | No | Logistic | No | Not reported |
Ziai [35] | Cohort | Consecutive | 170 | 87 | 4 | 20.8 | 0% | Yes | No | Logistic | Cross-validation | Not reported |
Zis [39] | Cohort | Consecutive | 191 | 61 | 5 | 12.2 | 0% | No | No | Logistic | No | Hosmer-Lemeshow |
Appelboom [10] | Cohort | Consecutive | 84 | 18 | 5 | 3.6 | Unclear | Yes | Yes | Logistic (Update) | No | Not reported |
Creutzfeld [47] | Cohort | Consecutive | 424 | 187 | 7 | 26.7 | 0% | No | No | Logistic | No | Hosmer-Lemeshow |
Flemming [18] | Cohort | Consecutive | 81 | 24 | 2 | 12 | 0% | Yes | No | Decision Tree | No | Not reported |
Flemming´ [18] | Cohort | Consecutive | 81 | 51 | 3 | 10 | 0% | Yes | No | Decision Tree | No | Not reported |
Hallevy [25] | Cohort | Consecutive | 184 | 70 | 6 | 11.7 | 0% | No | No | Logistic | No | Not reported |
Ji [51] | Registry | Consecutive | 1953 | 912 | 7 | 130.3 | 12.6% | Yes | Yes | Logistic | Split sample | Hosmer-Lemeshow |
Lisk [22] | Cohort | Consecutive | 75 | 35 | 4 | 8.8 | 0% | Yes | No | Logistic | No | Hosmer-Lemeshow |
Lisk´ [22] | Cohort | Consecutive | 42 | 9 | 3 | 3 | 0% | Yes | No | Logistic | No | Hosmer-Lemeshow |
Neidert [11] | Cohort | Consecutive | 67 | 28 | 8 | 3.5 | 0% | No | No | Univariate analysis | No | Not reported |
Misra [15] | Cohort | Not reported | 38 | Not reported | 4 | n/a | Unclear | Yes | No | Logistic | No | Not reported |
Mittal [52] | Cohort | Consecutive | 92 | 62 | 5 | 6 | 0% | No | Yes | Logistic (update) | No | Not reported |
Portenoy [20] | Cohort | Consecutive | 112 | 41 | 3 | 13.7 | 0% | No | No | Logistic | No | Hosmer-Lemeshow |
Poungvarin [55] | Cohort | Consecutive | 995 | 402 | 4 | 100.5 | 0% | Yes | No | Logistic | No | Not reported |
Rost [57] | Cohort | Consecutive | 418 | 121 | 5 | 24.2 | 13.4% | Yes | No | Logistic | Split sample | Not reported |
Shah [17] | Cohort | Not reported | 53 | 29 | 2 | 12 | 0% | No | No | Logistic | No | Not reported |
Shaya [19] | Cohort | Consecutive | 50 | n/a | 3 | n/a | 0% | No | No | Ordered logistic | No | Not reported |
Weimar [42] | RCTs | Not reported | 564 | 171 | 3 | 57 | 0% | Yes | No | Logistic (update) | No | Calibration plot |
Weimar´ [37] | Cohort | Consecutive | 207 | 78 | 2 | 39 | 20.4% | Yes | Yes | Logistic | No | Not reported |
Weimar´´ [43] | Registry | Consecutive | 340 | 89 | 3 | 29.7 | 27% | Yes | Yes | Logistic (update) | No | Not reported |
Cheung [46] | Cohort | Consecutive | 141 | 31a | 5 | 6.2a | 0.7% | Yes | No | Logistic | No | Not reported |
49b | 9.8b | |||||||||||
Cheung´ [46] | Cohort | Consecutive | 141 | 31a | 5 | 6.2a | 0.7% | Yes | No | Logistic (update) | No | Not reported |
49b | 9.8b | |||||||||||
Cho [14] | RCT | Consecutive | 226 | 42a | 3 | 14a | 0% | Yes | No | Logistic | No | Not reported |
Unclearb | n/ab | |||||||||||
Godoy [62] | Cohort | Consecutive | 153 | 53a | 5 | 10.6a | 0% | Yes | No | Logistic (update) | No | Not reported |
59b | 11.8b | |||||||||||
Godoy´ [62] | Cohort | Consecutive | 153 | 53a | 5 | 10.6a | 0% | Yes | No | Logistic (update) | No | Not reported |
59b | 11.8b | |||||||||||
Lei [13] | Cohort | Consecutive | 170 | 43a | 4 | 10.8a | 0% | No | Yes | Logistic | Split sample | Not reported |
90b | 20b | |||||||||||
Stein [16] | Cohort | Consecutive | 110 | 31a | 4 | 7.8a | 0% | Yes | No | Logistic | Split sample | Not reported |
86b | 4.5b |
Number of patients and events
Handling of missing data and loss to follow-up
Methods used for tool derivation
Prognostic tool performance
Prognostic tools | Nr studies | Nr tools | Pooled c-stat | 95%CI | I2 | ß | 95%CI | p | ||
---|---|---|---|---|---|---|---|---|---|---|
Lower | Upper | Lower | Upper | |||||||
Overall | 40 | 53 | 0·878 | 0·864 | 0·891 | 79% | – | – | – | – |
Mortality prediction tools | 30 | 38 | 0·880 | 0·865 | 0·894 | 80% | -0·007a | -0·039a | 0·026a | 0·679 |
Functional outcome prediction tools | 13 | 15 | 0·872 | 0·842 | 0·901 | 77% | ||||
Logistic regression based tools | 37 | 43 | 0·874 | 0·858 | 0·889 | 76% | 0·018b | -0·034b | 0·070b | 0·490 |
Machine learning algorithms | 6 | 9 | 0·898 | 0·821 | 0·976 | 88% |