Introduction
Expression of IGF2BP2 and metabolic disease
Metabolic diseases | SNPs | Population | Biological functions | Refs. |
---|---|---|---|---|
Diabetes | rs4402960 | Chinese Han population | Protected against T2D, enhanced the therapeutic efficacy of repaglinide, and reduced the effect of pioglitazone on PPG, TG, and HDL-C | |
Japanese population | \ | [32] | ||
Asians | \ | |||
Iceland’s population | Decreased fasting insulin levels, impaired β-cell function | [34] | ||
Greek-Cypriot population | \ | [35] | ||
Czech population | \ | [26] | ||
Germany population | \ | |||
Lebanese Arabs | \ | [37] | ||
Arab population | \ | [38] | ||
Moroccan population | \ | [38] | ||
Tunisian population | \ | [39] | ||
India’s population | \ | [40] | ||
\ | Predict the occurrence and diagnosis of GDM | [43] | ||
Poland population | Influenced the length of gestation and the Apgar scores of newborns | [44] | ||
rs1470579 | Chinese Han population | Reduced the therapeutic efficacy of repaglinide and the effect of pioglitazone on PPG, TG, and HDL-C | ||
Lebanese population | \ | [46] | ||
Iranian population | \ | [47] | ||
rs11705701 | Mexican American population | Affected insulin resistance | [53] | |
Russian population | Contributed to T2D risk, decreased levels of p58 and increased levels of p66 of the IGF2BP2 in adipose tissue of non-obese individuals | [51] | ||
Poland population | Influenced the length of gestation and the Apgar scores of newborns | [44] | ||
\ | Associated with prediabetes | [54] | ||
rs9826022 | \ | \ | [48] | |
rs11927381 | Chinese Han population | \ | [55] | |
rs7640539 | [55] | |||
rs6777038 | \ | Associated with GADA negative diabetes | [56] | |
rs16860234 | ||||
rs7651090 | ||||
Nonalcoholic steatohepatitis | \ | \ | Increased the ratio of C18:C16 and the expression of ELOVL6 | [63] |
\ | \ | Promoted the de-differentiated cells toward steatohepatitis-associated cirrhosis development via accelerating DR | [64] | |
Obesity | \ | \ | IGF2BP2 deficiency induced the resistance to diet-induced obesity and fatty liver, and showed great glucose tolerance and insulin sensitivity | [12] |
Fatty liver | \ | \ | IGF2BP2 knockout impaired fatty acid oxidation and promoted modest diet-induced fatty liver | [13] |
Expression of IGF2BP2 and diabetes
Expression of IGF2BP2 rs4402960 and rs1470579 in diabetes
Other IGF2BP2 SNPs in diabetes
The mechanisms underlying IGF2BP2 in diabetic nephropathy
IGF2BP2 in fatty liver and steatohepatitis and the specific mechanisms
IGF2BP2 and cancers
Cancer | Expression | Role | Biological function | Upstream | Target | Refs. |
---|---|---|---|---|---|---|
AML | ↑ | Oncogene | Cell growth | / | [65] | |
Breast cancer | / | Oncogene | Proliferation, invasion | miR-1193 | ERK, PI3K/Akt | [7] |
↑ | Oncogene | / | / | / | [14] | |
↑ | Oncogene | Autoantibody response | / | / | [73] | |
↑ | Oncogene | Tumor growth | CCN6 | / | [74] | |
Colorectal cancer | ↑ | Oncogene | Proliferation, survival | / | miR-195/RAF1 | [81] |
/ | Oncogene | Invasion, proliferation, migration, MDV, EMT, apoptosis | LncRNA HOTAIR | / | [9] | |
/ | Oncogene | Glycolysis, proliferation | LINRIS | MYC | [100] | |
/ | / | Proliferation, migration, invasion, autophagy | 91H | IGF2 | [103] | |
/ | / | Cell self-renewal, stem cell frequency, migration, tumorigenesis, metastasis | METTL3 | SOX2 | [15] | |
Glioma | / | / | Proliferation, migration, invasion | miR-188 | / | [91] |
↑ | Oncogene | Proliferation, invasion | miR-138 | / | [17] | |
HCC | ↑ | Oncogene | Proliferation, migration, invasion | miR-216b | / | [92] |
/ | Oncogene | Proliferation, metastasis | lncRNA RHPN1-AS1/miR-596 | / | [104] | |
/ | / | / | MIRLRT7A3/miR-let-7a | / | [18] | |
↑ | Oncogene | Proliferation | FEN1 | [66] | ||
Lung cancer | / | / | Growth, invasion, cell cycle | miR-485-5p | / | [95] |
HNSCC | ↑ | Oncogene | Scavenging and degradation, synthesis and metabolism, cell growth, death and motility | / | / | [67] |
PDAC | ↑ | Oncogene | Aerobic glycolysis, proliferation | / | GLUT1 | [68] |
↑ | Oncogene | Cell growth | miR-141 | PI3K/Akt | [20] | |
↑ | Oncogene | Proliferation, stemness-like properties | LncRNA DANCR | [70] | ||
GBC | ↑ | Oncogene | Tumor growth | / | / | [71] |
ERMS | / | / | Survival and growth | HMGA2 | NRAS | [85] |