Background
Biogenesis, classification and characteristics of circRNAs
Biological roles and mechanistic models of circRNAs
Symbol | Function | Expression | Cancer Type | Mechanism | PMID |
---|---|---|---|---|---|
circ-ANAPC7 (hsa_circ_0005785) | / | Upregulated | Acute Myeloid Leukemia. | circ-ANAPC7/miR-181 | 29,969,755 |
hsa_circ_0075001 | / | Upregulated | Acute Myeloid Leukemia. | / | 28,971,903 |
circ-DLEU2 | oncogene | Upregulated | Acute Myeloid Leukemia. | circ-DLEU2/miR-496/PRKACB | 30,037,980 |
hsa_circ_0004277 | / | Downregulated | Acute Myeloid Leukemia. | / | 28,282,919 |
circ-HIPK2 | / | Downregulated | Acute Myeloid Leukemia. | circ-HIPK2/miR-124-3p | 29,844,435 |
hsa_circ_0075825 | / | Upregulated | Basal cell carcinoma | / | 27,097,056 |
hsa_circ_0075828 | / | Upregulated | Basal cell carcinoma | / | 27,097,056 |
hsa_circ_0022383 | / | Downregulated | Basal cell carcinoma | / | 27,298,156 |
hsa_circ_0022392 | / | Downregulated | Basal cell carcinoma | / | 27,298,156 |
circRNA-MYLK(hsa_circ_0002768) | oncogene | Upregulated | Bladder Cancer | circRNA-MYLK/miR-29a/VEGFA/VEGFR2 | 28,687,357 |
circTCF25(hsa_circ_0041103) | oncogene | Upregulated | Bladder Cancer | circTCF25/miR-103-3p/miR-107/CDK6 | 27,484,176 |
circ-BCRC4 | tumor suppressor | Downregulated | Bladder Cancer | circ-BCRC4.miR-101/EZH2 | 29,270,748 |
circ-ITCH | tumor suppressor | Downregulated | Bladder Cancer | circ-ITCH/miR-17/miR-224/p21/PTEN | 29,386,015 |
circHIPK3 | tumor suppressor | Downregulated | Bladder Cancer | circHIPK3/miR-558/HPSE | 28,794,202 |
circ-ABCB10 (hsa_circ_0008717) | oncogene | Upregulated | Breast Cancer | circ-ABCB10/miR-1271 | 28,744,405 |
circ-DENND4C | oncogene | Upregulated | Breast Cancer | HIF1α/circ-DENND4C | 28,739,726 |
circGFRA1 (hsa_circ_0005239) | oncogene | Upregulated | Breast Cancer | circGFRA1/miR-34a/GFRA1 | 29,037,220 |
hsa_circ_0001982 | oncogene | Upregulated | Breast Cancer | hsa_circ_0001982/miR-143 | 28,933,584 |
hsa_circ_0011946 | oncogene | Upregulated | Breast Cancer | hsa_circ_0011946/miR-26a/miR-26b / RFC3 | 29,593,432 |
circ-Foxo3 | tumor suppressor | Downregulated | Breast Cancer | p53/miR-22/ miR-136/ miR-138/ miR-149/ miR-433/ miR-762/ miR-3614-5p/ miR-3622b-5p | 27,886,165/26657152 |
hsa_circ_000911 | tumor suppressor | Downregulated | Breast Cancer | hsa_circ_000911/miR-449a/Notch1 | 29,431,182 |
hsa_circ_0000284 | oncogene | Upregulated | Cervical Cancer | hsa_circ_0000284/miR-506/Snail-2 | 29,511,454 |
hsa_circ_0023404 | oncogene | Upregulated | Cervical Cancer | hsa_circ_0023404/miR-5047/VEGFA | 31,082,770 |
CDR1as (hsa_circ_0001946,ciRS-7) | oncogene | Upregulated | Cholangiocarcinoma | / | 29,424,892 |
hsa_circ_0001649 | tumor suppressor | Downregulated | Cholangiocarcinoma | / | 29,337,065 |
circ-CBFB | oncogene | Upregulated | Chronic Lymphocytic Leukemia | circ-CBFB/miR-607/FZD3/Wnt/β-catenin | 29,902,450 |
circ_0132266 | / | Downregulated | Chronic Lymphocytic Leukemia | circ_0132266/miR-337-3p/PML | 31,152,142 |
circ-BA9.3 | oncogene | Upregulated | Chronic Myelogenous Leukaemia | circ-BA9.3/ABL1/BCR-ABL1 | 30,224,298 |
hsa_circ_0080145 | oncogene | Upregulated | Chronic Myelogenous Leukaemia | hsa_circ_0080145/miR-29b | 30,205,959 |
hsa_circ_0001793 | / | Upregulated | Colorectal Cancer | / | 25,624,062 |
circ_001569 | oncogene | Upregulated | Colorectal Cancer | circ_001569/miR-145/E2F5/BAG4/FMNL2 | 27,058,418 |
circ-BANP | oncogene | Upregulated | Colorectal Cancer | circ-BANP/p-Akt | 28,103,507 |
circCCDC66 | oncogene | Upregulated | Colorectal Cancer | circCCDC66/miR-33b/ miR-93 | 28,249,903 |
circHIPK3 | oncogene | Upregulated | Colorectal Cancer | circ-HIPK/miR-7/FAK//IGF1R/ EGFR/YY1 | 29,549,306 |
hsa_circ_0000069 | oncogene | Upregulated | Colorectal Cancer | / | 28,003,761 |
CDR1as (hsa_circ_0001946, ciRS-7) | oncogene | Upregulated | Colorectal Cancer | hsa_circ_0001946/miR-7/EGFR/ RAF1 | 25,624,062/28174233 |
hsa_circ_0007534 | oncogene | Upregulated | Colorectal Cancer | / | 29,364,478 |
hsa_circ_000984 | oncogene | Upregulated | Colorectal Cancer | hsa_circ_000984/miR-106b/CDK6 | 29,207,676 |
hsa_circ_0020397 | oncogene | Upregulated | Colorectal Cancer | hsa_circ_0020397/miR-138/TERT/ PD-L1 | 28,707,774 |
hsa_circ_0136666 | oncogene | Upregulated | Colorectal Cancer | hsa_circ_0136666/miR-136/SH2B1 | 30,370,521 |
hsa_circ_0000523 | / | Downregulated | Colorectal Cancer | / | 25,624,062 |
hsa_circ_0001346 | / | Downregulated | Colorectal Cancer | / | 25,624,062 |
hsa_circ_0001649 | / | Downregulated | Colorectal Cancer | / | 29,421,663 |
cir-ITCH | tumor suppressor | Downregulated | Colorectal Cancer | cir-ITCH/miR-7/ miR-20a/ miR-214/Wnt/β-catenin | 26,110,611 |
hsa_circ_0003906 | tumor suppressor | Downregulated | Colorectal Cancer | / | 29,123,417 |
cric-FBXW7 (hsa_circ_001988) | tumor suppressor | Downregulated | Colorectal Cancer | / | 26,884,878 |
hsa_circ_0070933 | / | Upregulated | Cutaneous squamous cell carcinoma | / | 27,298,156 |
hsa_circ_0070934 | / | Upregulated | Cutaneous squamous cell carcinoma | / | 27,298,156 |
hsa_circ_0022383 | / | Downregulated | Cutaneous squamous cell carcinoma | / | 27,298,156 |
hsa_circ_0022392 | / | Downregulated | Cutaneous squamous cell carcinoma | / | 27,298,156 |
circ-HIPK3 | oncogene | Upregulated | Epithelial Ovarian Cancer | / | 29,949,144 |
circ-SLC7A5 | oncogene | Upregulated | Esophageal squamous cell carcinoma | / | 31,726,270 |
circPRKCI (hsa_circ_0067934) | oncogene | Upregulated | Esophageal squamous cell carcinoma | / | 27,752,108 |
hsa_circ_0000518 | / | Downregulated | Esophageal squamous cell carcinoma | hsa_circ_0000518/miR-181a-2/ miR-512-5p/ miR-521/ miR-556-5p/ miR-663b/ miR-1204 | 27,465,405 |
hsa_circ_0000554 | / | Downregulated | Esophageal squamous cell carcinoma | hsa_circ_0000554/miR-30c-1/ miR-30c-2/ miR-122/ miR-139-3p/ miR-339-5p/ miR-1912 | 27,465,405 |
circ-ITCH | tumor suppressor | Downregulated | Esophageal squamous cell carcinoma | miR-7/ miR-17/ miR-214/Wnt/β-catenin | 25,749,389 |
circPVT1 (hsa_circ_0001821) | / | Upregulated | Gastric Cancer | / | 31,616,472 |
circLMTK2 | oncogene | Upregulated | Gastric Cancer | circLMTK2/miR-150-5p/c-Myc | 31,722,712 |
has-circRNA7690–15 | oncogene | Upregulated | Gastric Cancer | / | 28,980,874 |
hsa_circ_0047905 | oncogene | Upregulated | Gastric Cancer | / | 28,980,874 |
hsa_circ_0138960 | oncogene | Upregulated | Gastric Cancer | / | 28,980,874 |
hsa_circ_0001017 | / | Downregulated | Gastric Cancer | / | 29,098,316 |
hsa_circ_0001649 | / | Downregulated | Gastric Cancer | / | 28,167,847 |
hsa_circ_0003159 | / | Downregulated | Gastric Cancer | / | 28,618,205 |
hsa_circ_0014717 | / | Downregulated | Gastric Cancer | / | 28,544,609 |
hsa_circ_0061276 | / | Downregulated | Gastric Cancer | / | 29,098,316 |
hsa_circ_0074362 | / | Downregulated | Gastric Cancer | / | 29,240,459 |
hsa_circ_002059 | tumor suppressor | Downregulated | Gastric Cancer | / | 25,689,795 |
circ-LPHN2 (hsa_ circRNA_100269) | tumor suppressor | Downregulated | Gastric Cancer | hsa_ circRNA_100269/miR-630 | 28,657,541 |
circ-HuR (hsa_circ_0049027) | tumor suppressor | Downregulated | Gastric Cancer | circ-HuR/CNBP | 31,718,709 |
circLARP4 | tumor suppressor | Downregulated | Gastric Cancer | circLARP4/miR-424/LATS1 | 28,893,265 |
hsa_circ_0000096 | tumor suppressor | Downregulated | Gastric Cancer | hsa_circ_0000096/cyclin D1/CDK6/ MMP2/ MMP9 | 28,081,541 |
hsa_circ_0000181 | tumor suppressor | Downregulated | Gastric Cancer | / | 28,940,688 |
hsa_circ_0000190 | tumor suppressor | Downregulated | Gastric Cancer | / | 28,130,019 |
hsa_circ_0000520 | tumor suppressor | Downregulated | Gastric Cancer | / | 29,103,021 |
hsa_circ_0000745 | tumor suppressor | Downregulated | Gastric Cancer | / | 28,974,900 |
hsa_circ_0001895 | tumor suppressor | Downregulated | Gastric Cancer | / | 28,443,463 |
hsa_circ_0067582 | tumor suppressor | Downregulated | Gastric Cancer | / | 31,721,300 |
circ-VCAN | / | Upregulated | Gliomas | / | 26,873,924 |
circ_0001730 | oncogene | Upregulated | Gliomas | circ_0001730/miR-326/Wnt7B | 31,304,776 |
circ-SHKBP1 | oncogene | Upregulated | Gliomas | circ-SHKBP1/miR-544a/miR-379/FOXP1/FOXP2 | 29,499,945 |
circ-ZNF292 | oncogene | Upregulated | Gliomas | circ-ZNF292/Wnt/β-catenin | 27,613,831 |
circTTBK2 (hsa_circ_0000594) | oncogene | Upregulated | Gliomas | circTTBK2/miR-217/HNF1β/Derlin-1 | 28,219,405 |
cric-FBXW7 (hsa_circ_001988) | oncogene | Upregulated | Gliomas | / | 28,903,484 |
hsa_circ_0046701 | oncogene | Upregulated | Gliomas | hsa_circ_0046701/miR-142/ITGB8 | 29,337,055 |
CDR1as (hsa_circ_0001946,ciRS-7) | / | Downregulated | Gliomas | miR-671-5p/CDR1as/CDR1/VSNL1 | 26,683,098 |
circ-BRAF | / | Downregulated | Gliomas | / | 28,236,760 |
circ-SHPRH | tumor suppressor | Downregulated | Gliomas | / | 29,343,848 |
circSMARCA5(hsa_circ_0001445) | tumor suppressor | Downregulated | Gliomas | circSMARCA5/SRSF1 | 29,415,469 |
circRNA_100338 | / | Upregulated | Hepatocellular Carcinoma | circRNA_100338/miR-141-3p | 31,157,168/28710406 |
hsa_circ_0000284 | / | Upregulated | Hepatocellular Carcinoma | hsa_circ_0000284/miR-124/miR-152 /miR-193a/miR-29a/miR-29b/miR-338/miR-379/miR-584/miR-654 | 27,050,392 |
circ_000839 | oncogene | Upregulated | Hepatocellular Carcinoma | circ_000839/miR-200b | 28,695,771 |
circPRKCI (hsa_circ_0067934) | oncogene | Upregulated | Hepatocellular Carcinoma | has_circ_0067934/miR-1324/FZD5/Wnt/β-catenin | 29,458,020 |
hsa_circ_0005075 | oncogene | Upregulated | Hepatocellular Carcinoma | / | 27,258,521 |
CDR1as (hsa_circ_0001946, ciRS-7) | / | Downregulated | Hepatocellular Carcinoma | hsa_circ_0001946/miR-7/EGFR/CCNE1/PIK3CD | 28,892,615/27391479 |
hsa_circ_0001649 | / | Downregulated | Hepatocellular Carcinoma | / | 26,600,397 |
hsa_circ_0004018 | / | Downregulated | Hepatocellular Carcinoma | / | 28,938,566 |
hsa_circ_0067531 | / | Downregulated | Hepatocellular Carcinoma | / | 29,251,325 |
circC3P1 | tumor suppressor | Downregulated | Hepatocellular Carcinoma | circC3P1/miR-4641/PCK1 | 29,608,893 |
circMTO1 (hsa_circ_0007874) | tumor suppressor | Downregulated | Hepatocellular Carcinoma | circMTO1/miR-9/p21 | 28,520,103 |
circSMARCA5 (hsa_circ_0001445) | tumor suppressor | Downregulated | Hepatocellular Carcinoma | circSMARCA5 /miR-17-3p/miR-181-5p/TIMP3 | 29,378,234 |
circZKSCAN1 (hsa_circ_0001727) | tumor suppressor | Downregulated | Hepatocellular Carcinoma | / | 28,211,215 |
hsa_circ_0003570 | tumor suppressor | Downregulated | Hepatocellular Carcinoma | / | 28,493,512 |
hsa_circ_0005986 | tumor suppressor | Downregulated | Hepatocellular Carcinoma | hsa_circ_0005986/miR-129/Notch1 | 28,410,211 |
circRNA_100876 | / | Upregulated | Lung Cancer | / | 28,343,871 |
circ-CER | oncogene | Upregulated | Lung Cancer | circ-CER/miR-136/MMP13 | 28,343,871 |
circMAN2B2 | oncogene | Upregulated | Lung Cancer | circMAN2B2/miR-1275/FOXK1 | 29,550,475 |
circPRKCI (hsa_circ_0067934) | oncogene | Upregulated | Lung Cancer | circPRKCI/miR-545/ miR-589/E2F7 | 29,588,350 |
circRNA_102231 | oncogene | Upregulated | Lung Cancer | / | 29,602,132 |
hsa_circ_0000064 | oncogene | Upregulated | Lung Cancer | hsa_circ_0000064/MMP2/MMP9 | 29,223,555 |
hsa_circ_0007385 | oncogene | Upregulated | Lung Cancer | hsa_circ_0007385/miR-181 | 29,372,377 |
hsa_circ_0012673 | oncogene | Upregulated | Lung Cancer | hsa_circ_0012673/miR-22/ErbB3 | 29,366,790 |
hsa_circ_0013958 | oncogene | Upregulated | Lung Cancer | hsa_circ_0013958/miR-134/cyclin D1 | 28,685,964 |
hsa_circ_0014130 | oncogene | Upregulated | Lung Cancer | / | 29,440,731 |
circRNA-FOXO3 | tumor suppressor | Downregulated | Lung Cancer | / | 29,620,202 |
hsa_circ_0013958 | tumor suppressor | Downregulated | Lung Cancer | hsa_circ_0013958/miR-7/miR-214/Wnt/b-catenin | 27,642,589 |
circDOCK1 | oncogene | Upregulated | Oral Squamous Cell Carcinoma | circDOCK1/mi-196a/BIRC3 | 29,286,141 |
hsa_circRNA_103801 | / | Upregulated | Osteosarcoma | hsa_circRNA_103801/miR-370 | 28,957,794 |
circ_0102049 | oncogene | Upregulated | Osteosarcoma | circ_0102049/miR-1304-5p/MDM2 | 31,727,503 |
circ-UBAP2 | oncogene | Upregulated | Osteosarcoma | circ-UBAP2 /miR-143 | 28,977,896 |
circPVT1 (hsa_circ_0001821) | oncogene | Upregulated | Osteosarcoma | circPVT1/ABCB1 | 29,559,849 |
hsa_circ_0001564 | oncogene | Upregulated | Osteosarcoma | hsa_circ_0001564/miR-29c | 29,229,385 |
hsa_circ_0009910 | oncogene | Upregulated | Osteosarcoma | circ-UBAP2/miR-449a/IL-6R/JAK1/STAT3 | 29,117,539 |
hsa_circ_0016347 | oncogene | Upregulated | Osteosarcoma | hsa_circ_0016347/miR-124/caspase-1 | 28,424,426 |
hsa_circRNA_104980 | / | Downregulated | Osteosarcoma | / | 28,957,794 |
hsa_circ_0005397 | / | Upregulated | Pancreatic cancer | hsa_circ_0005397/miR-26b/miR-125a/miR-181a/miR-330/miR-382 | 27,997,903 |
circ-ASH2L | oncogene | Upregulated | Pancreatic cancer | circ-ASH2L/miR-34a/Notch1 | 31,718,694 |
circ-LDLRAD3 | oncogene | Upregulated | Pancreatic cancer | / | 29,307,994 |
circRNA_100782 | oncogene | Upregulated | Pancreatic cancer | circRNA_100782/miR-124/IL6/STAT | 29,255,366 |
circ-ANAPC7 (hsa_circ_0005785) | / | Downregulated | Pancreatic cancer | hsa_circ_0005785/miR-181a/miR-181b/miR-181d/miR-338/miR-526b | 27,997,903 |
circ-SMARCA5 | oncogene | Upregulated | Prostate cancer | / | 28,765,045 |
circMTO1 (hsa_circ_0007874) | tumor suppressor | Downregulated | Prostate cancer | circMTO1/miR-17-5p | 31,713,278 |
miRNA sponges
Interaction with RBPs
Regulators of transcription
Translation of circRNAs
CircRNAs as modulators of the tumour microenvironment
Interaction with TME | CircRNA name | Expression | Function | Cancer types | Biological activities | Clinical correlation | Molecular axis |
---|---|---|---|---|---|---|---|
circRNAs and CAEs | circ-MYLK | Upregulated | oncogene | Breast cancer | Proliferation, migration, apoptosis, angiogenesis, metastasis, EMT | TNM stage, pathological grade | circ-MYLK/miR-29a/VEGFA/VEGFR2 |
circ-SMARCA5 | Downregulated | tumor suppressor | Glioblastoma multiform | Angiogenesis | Overall Survival, Progression-Free Survival | circ-SMARCA5/SRSF1/VEGFA | |
circ-DICER1 | Upregulated | oncogene | Glioma | Proliferation, migration, angiogenesis | / | MOV10/circ-DICER1/ miR-103a-3p/miR-382-5p/ZIC4 | |
circ-SHKBP1 | Upregulated | oncogene | Glioma | Proliferation, migration, angiogenesis | / | circ-SHKBP1/miR-544a/FOXP1, circ-SHKBP1/miR-379/FOXP2 | |
circ-IARS | Upregulated | oncogene | Pancreatic ductal adenocarcinoma | Invasion, metastasis, endothelial monolayer permeability | Vascular invasion, TNM stage, liver metastasis, postoperative survival time | circ-IARS/miR-122/RhoA/F-actin/ZO-1 | |
circ-HIPK3 | Downregulated | tumor suppressor | Bladder cancer | Proliferation, migration, invasion, angiogenesis, metastasis | Pathological grade, tumor invasion, lymph node metastasis | circ-HIPK3/miR-558/HPSE | |
ciRS-7 | Upregulated | oncogene | Multiple tumours | Angiogenesis, immune and stromal infiltration, ECM organization, integrin and collagen binding | / | cir-DR1as/TGF-β signaling pathway/ECM–receptor interaction | |
circRNAs and immune cells | ciRS-7 | Upregulated | oncogened | Esophageal squamous cell carcinoma | Proliferation, migration, invasion, metastasis | TNM stage, pathological grade, overall survival, disease-free survival | ciRS-7miR-7/KLF4/NF-κB |
Multiple tumours | Angiogenesis, immune and stromal infiltration, ECM organization, integrin and collagen binding | / | cir-DR1as/TGF-β signaling pathway/ECM– receptor interaction | ||||
has_circ_0020397 | Upregulated | oncogene | Colorectal cancer | Proliferation, invasion, apoptosis | / | has_circ_0020397/miR-138/TERT/PD-L1 | |
hsa_circ_0064428 | Downregulated | tumor suppressor | Hepatocellular carcinoma | / | Tumour size, metastasis, overall survival | / | |
circRNA-000911 | Downregulated | tumor suppressor | Breast cancer | Proliferation, migration and invasion, apoptosis | / | circ-000911/ miR-449a /Notch1/NF-κB | |
circ-0000977 | Upregulated | oncogene | Pancreatic cancer | Immune escape, induction by hypoxia | / | circ-0000977/miR-153/HIF1α/ADAM1 | |
circ-Foxo3 | Downregulated | tumor suppressor | Breast cancer | Proliferation, apoptosis, tumor growth | / | circ-Foxo3/MDM2/P53/Foxo3 | |
CircRNAs and CAFs | ciRS-7 | Upregulated | oncogene | Multiple tumours | Angiogenesis, immune and stromal infiltration, ECM organization, integrin and collagen binding | / | cir-DR1as/TGF-β signaling pathway/ECM– receptor interaction |
circRNAs and CSCs | hg19_circ_0005033 | Upregulated | oncogene | Laryngeal squamous cell carcinoma | Proliferation, migration, invasion, chemotherapy resistance | / | hg19_circ_0005033/miR-4521/miR-339-5p/STA T5A |
circRNAs and hypoxia | circ-DENND2A | Upregulated | oncogene | Glioma | Migration, invasion, induction by hypoxia | / | circ-DENND2A/miR-625-5p/HIF1α |
circ-PIP5K1A | Upregulated | oncogene | Non-small cell lung cancer | Proliferation, invasion, migration, metastasis, EMT | / | circ-PIP5K1A/miR-600/HIF-1α | |
circ-0000977 | Upregulated | oncogene | Pancreatic cancer | Immune escape, induction by hypoxia | / | circ-0000977/miR-153/HIF1α/ADAM1 | |
circ-CDR1as | Downregulated | tumor suppressor | Ovarian cancer | Proliferation, migration, invasion | / | circ-CDR1as/miR-135b-5p/HIF1AN | |
circ-DENND4C | Upregulated | oncogene | Breast cancer | Proliferation, induction by hypoxia | / | HIF1α/circ-DENN4C | |
circRNAs and ECM | hsa_circ_0000096 | Downregulated | tumor suppressor | Gastric cacner | Proliferation, migration | Gender, invasion, TNM stage | hsa_circ_0000096/MMP2/MMP9 |
hsa_circ_0000064 | Upregulated | oncogene | Non-small cell lung cancer | Proliferation, cell cycle, apoptosis, migration, invasion | T stage, TNM stage, lymph node metastasis | hsa_circ_0000064/MMP2/MMP9 | |
ciRS-7 | Upregulated | oncogene | Multiple tumours | Angiogenesis, immune and stromal infiltration, ECM organization, integrin and collagen binding | / | cir-DR1as/TGF-β signaling pathway/ECM– receptor interaction | |
circ-ERBB2 | Upregulated | oncogene | Gastric cacner | Proliferation, apoptosis, migration, invasion | Tumor size, invasion depth, overall survival | circ-ERBB2/miR-637/MMP-19 | |
hsa_circ_0044520 | Upregulated | / | Laryngeal Squamous Cell Carcinoma | Collagen synthesis | / | hsa_circ_0044520/COL1A1 | |
hsa_circ_0044529 | Upregulated | / | Laryngeal Squamous Cell Carcinoma | Collagen synthesis | / | hsa_circ_0044529/COL1A1 |
CircRNAs and CAEs
CircRNAs and immune cells
CircRNAs and macrophages
CircRNAs and lymphocytes
CircRNAs and immune-related molecules
CircRNAs and exosomes
CircRNAs and Cancer stem cells
CircRNAs and CAFs
CircRNAs and extracellular matrix
CircRNAs and hypoxia
The potential of circRNAs as prospective biomarkers or targets in cancer clinics
circRNAs as novel targets reversing drug resistance for cancer therapeutics
CircRNA name | Expression | Function | Cancer types | Biological activities | Clinical correlation | Molecular axis |
---|---|---|---|---|---|---|
circ-PVT1 | Upregulated | oncogene | Osteosarcoma | Resistance to doxorubicin and cisplatin | Enneking stage, lung metastasis, overall survival | circ-PVT1/ABCB1 |
hsa_circ_0004015 | Upregulated | oncogene | Non-small cell lung cancer | Resistance to gefitinib, Proliferation, colony-formation ability, invasion | Differentiation grade, tumor invasion, TNM stage | hsa_circ_0004015/miR-1183/PDPK1 |
circ_0006528 | Upregulated | oncogene | Breast cancer | Resistance to adriamycin, DNA synthesis, proliferation, invasion, migration, cell cycle, apoptosis | TNM stage, relapse-free survival, overall survival | circ_0006528/miR-7-5p/ Raf1/MEK/ERK |
hsa_circ_0000504 | Upregulated | / | Colorectal cancer | Resistance to 5-fluorouracil | / | hsa_circ_0000504/ hsa-miR-485-5p/STAT3 |
hsa_circ_0043632 | Upregulated | / | Non-small cell lung cancer | Resistance to EGFR-TKI inhibitor AZD9291 | / | hsa_circ_0043632/miR-492/ TIMP2 |
circ-MTO1 | Downregulated | / | Breast cancer | Resistance to monastrol, proliferation | / | circ-MTO1/TRAF4/Eg5 |
hsa-circ-0001258 | Downregulated | / | Osteosarcoma | Resistance to doxorubicin | / | hsa-circ-0001258/ hsa-miR-744-3p/GSTM2 |
CircPAN3 | / | / | AML | Resistance to doxorubicin | / | circPAN3/miR-153-5p / miR-183-5p-XIAP |