Background
Health-related quality of life (HRQoL) may be influenced by a number of individual disease-related factors such as illness, functional status and general health perception [
1]. However quality of life varies greatly despite any similarities in patients’ stroke severity and current health state [
2]. In the last two decades, socioeconomic factors have also been recognised to affect HRQoL [
3].
Socioeconomic status (SES) comprises a number of different aspects of an individual’s economic resources and social status, commonly including a combination of individual-level factors such as income, education and occupation and/ or area-level factors of economic resources such as housing. These markers have been frequently used as indicators, individually or in combination, to measure SES [
4]. Previous literature provides evidence that socioeconomic disparities have a profound impact on stroke mortality and functional outcomes including mobility and cognition with little or no exploration of quality of life as an outcome [
5].
To date, the effect of SES on HRQoL after stroke has not been systematically reviewed. There is conflicting evidence about the association between SES and HRQoL after stroke. Some investigators have reported associations between unemployment and manual occupation with poor HRQoL, [
6,
7] some reporting associations between level of education and occupation limited to the physical or mental aspect of HRQoL, [
8,
9] while in some reports, the evidence was equivocal [
10]. With increasing recognition of the role of social determinants of health as important outcomes following stroke, [
11] a systematic review of the association between SES and HRQoL will fill an important gap in our understanding of how these factors may influence the outcomes for people with stroke. Using a systematic review design, we aimed to determine the association between socioeconomic status and HRQoL in people who have had a stroke.
Methods
We systematically identified studies undertaken to examine the association between SES and HRQoL after stroke. This review protocol has been registered in the International Prospective Register of Systematic Review (PROSPERO) with the protocol number: CRD42022336865.
Data sources
We used the PECO framework: Population (P): people with stroke; Exposure (E): low socioeconomic status with indicators such as income, education, occupation: Comparison (C): high socioeconomic status; Outcome (O): health-related quality of life. Relevant keywords were used to build a search strategy in these databases to retrieve the appropriate publications (Supplementary Table S
1). To account for spelling variations, truncation and wildcards were used when building the search strategy for each database. Four databases: PubMed, SCOPUS, EMBASE, Web of Science were used in electronic search (Supplementary Table S
2). Manual search of reference lists in all included articles were also conducted.
Two reviewers (YAS and SK) with healthcare backgrounds and postgraduate qualifications in research independently screened the titles and abstracts of all retrieved studies for inclusion in full text screening. The inclusion criteria were: 1) primary cross sectional, cohort or case–control observational study; 2) SES indicator as a predictor or as a covariate; 3) all ages and settings; 4) articles published between January 2000 to May 2022; and 5) published in English language. The exclusion criteria were: 1) studies conducted in specific clinical populations such as cancer and kidney disease 2) review articles; 3) studies incorporating HRQoL as an outcome in an intervention study; 4) studies conducted to test the validity of an instrument; 5) studies among people with transient ischemia attack; and 6) qualitative studies. Studies that met the selection criteria were processed for data extraction. Discrepancies were resolved by discussion between the two reviewers. If a conflict persisted, the third reviewer (SLG), a senior epidemiologist, was consulted for the final decision. For the full text screening, the Kappa coefficient for agreement between the two initial reviewers was 0.87.
Data were extracted on author, year of publication, study design, location, data source, sample size, SES indicator, HRQoL instrument, follow-up time for cohort study, mean age, sex, stroke type, whether or not the study focused on SES, HRQoL measurement in any domains, other variables included in the multivariable analyses and method of statistical analysis. All data were extracted by YAS. Corresponding authors of relevant articles were contacted for further information if required. When multiple follow-up times were reported, the longest follow-up time was extracted. For studies that qualified for the meta-analysis, we extracted additional data including sample size, mean and standard deviation (SD) for each SES group, estimates with confidence interval (CI), P-value, t-value.
Quality assessment
The Joanna Briggs Institute (JBI) critical appraisal tools (cohort study, case–control study, cross-sectional study) [
12] were used to assess the quality of studies for all included papers by YAS. The study was scored 1 for Yes when it met the criterion, 0 for unclear and -1 for No. A question was excluded when it was not applicable to a particular study. To make all studies comparable when assessing quality, the scores gained from assessment tools for cohort and case–control studies were then converted to proportions. Quality was considered high (85%-100%), medium (65%-84) and low (below 65%). Uncertainties were discussed with the third reviewer (SLG).
Data synthesis and statistical analysis
We initially included all eligible studies of SES and HRQoL after stroke. For qualitative synthesis, we then limited the studies to those with outcomes of overall HRQoL. For the meta-analysis, we only included studies that incorporated use of overall HRQoL such as an overall quality of life score or a utility score. This included studies that had a similar construction of instruments for assessing HRQoL with multi-domains including physical, mental and social aspects.
We conducted a ‘global’ meta-analysis combining studies across different SES indicators. We examined the data source and study period to identify potentially overlapping population. If overlapping studies were found, we used the JBI tool to select the highest quality study for the ‘global’ meta-analysis. If the JBI score was the same, we selected the studies with larger study population then the most recent study. In the global meta-analysis, if multiple SES indicators were used in the one study, we prioritised SES indicators to those with an SES index—an indicator that includes multiple SES attributes, and then to individual-level SES markers in the following order: income, education level, occupation, work status and others. Because there is no individual best SES indicator, we prioritised income because it is suggested to be the optimal indicator for better material advantage and service access [
13] and has been shown to be the most important indicator in the adult population in health research [
14,
15]. If original data with number, mean and standard deviation (SD) of each group were available, and if more than two SES groups were reported, the groups were combined to generate medium/high and low/medium SES groups. Calculation of combined mean and SD was based on methods described by the Cochrane Collaboration documentation [
16]. If the original data were not available, the pre-calculated effect size data were used. In these instances, if more than two SES groups were reported, the highest and the lowest SES groups were extracted. When multiple models were reported, we selected the model that controlled for at least age and sex, these being the most important potential confounders, as well as allowing for consistency across studies. Given the heterogeneity of HRQoL measures, standardized mean differences (SMD) were used in the meta-analyses to enable comparison among studies with diverse HRQoL instruments. Analyses were repeated for each individual SES indicator across all available studies.
Sensitivity analyses were performed to exclude studies with a higher risk of bias. We conducted leave-one-out influence analysis to assess the outlier and repeated the meta-analysis without the potential influence study. A random-effect model was used to account for the heterogeneity between studies. Two-sided P-value ≤ 0.05 was considered as statistically significant. Heterogeneity was assessed using the Q statistic, I2 statistic and τ. We examined publication bias or small-study effects by inspecting funnel plots and using Egger’s test. For sub-group analyses, we stratified the studies by the study-level factors: adjusting for confounders, stroke type, and whether the study was designed to specifically investigate SES and study region. All statistical analyses and graphics were performed using R 4.1.2.
Discussion
In this systematic review we identify that reports on the associations between different markers of SES, such as income or education level, and overall HRQoL vary across studies. Based on general rule of interpretation of SMD, SMD < 0.2 is a “small” effect, between 0.2–0.5 is a “moderate” effect and > 0.8 is a “large” effect [
52]. Our findings demonstrated a moderate effect of low SES, such as low education level and low income on HRQoL among stroke survivors. Interestingly, in the meta-analysis, there was consistent evidence that exposure to low SES, compared to high SES, was associated with a poorer overall HRQoL after stroke regardless of SES indicator used.
Different SES indicators, such as education, income and a ‘global’ analysis using mixed indicators, have similar associations with HRQoL after stroke, supporting the notion that any aspect of SES could affect HRQoL after stroke. This study extends previous knowledge of the association between SES and stroke incidence and mortality [
5]. The findings suggest that SES should be considered as an important determinant of HRQoL, which is a key patient-reported outcome measure, in both acute and subacute settings. Our findings show that any SES indicator such as income and education have similar effects on people’s HRQoL after stroke. This is supported by our observation that SMD estimates and 95% CIs were similar across the global meta-analysis and each of the individual meta-analyses. It is widely acknowledged that income and education are moderately correlated [
53]. Low income or low paying jobs could limit the ability of stroke survivors to access fee-for-service treatments, thereby affecting recovery and HRQoL. A person’s income and education can affect their knowledge, attitudes, beliefs and access to healthy food, health services, health literacy, lifestyle, and environments, such as safe neighbourhood [
54]. Our findings suggest that an interplay of income, education and occupation may have similar influences in an individual’s physical, mental and social health measured through HRQoL after stroke.
Few studies, < 10%, were specifically designed to examine the associations between SES and HRQoL after stroke so there may be some selective reporting. This is because in studies not designed to examine SES and HRQoL investigators may not report findings for SES indicators if no statistically significant association was found in univariable analyses. Similarly, many investigators do not report the magnitude of the association between SES and HRQoL in multivariable models because the SES effect is no longer statistically significant. The lack of statistical significance of SES in this context may reflect mediation by other variables in the model, such as clinical factors or co-morbidities. This was shown in the results that after adjusted for potential confounders, the pooled estimate dramatically reduced from -0.46 to -0.08. Studies designed to examine SES differences in HRQoL after stroke are needed to provide the most robust approach, particularly with further exploration of other factors that potentially mediate the association between SES and HRQoL after stroke. Findings from these studies may be useful for developing interventions to address these differences in HRQoL by SES.
The mechanisms for the association between SES and HRQoL after stroke are likely to be complex. It is known that lower SES affects HRQoL. A person’s individual and community resources may play a role in an individual’s physical, mental, and social health measured through HRQoL after stroke. In countries with access to universal healthcare, free education and job markets, disparities in HRQoL after stroke persist [
6,
49]. HRQoL may also depend on the sense of control over health, which has been suggested to differ according to SES [
55,
56]. This sense of control over health is influenced by factors over the life course that are shaped by social factors including SES. These factors shape one’s understanding of people’s circumstances and health behaviours including responses to stress and adaptation of lifestyle, which may ultimately influence HRQoL during recovery from recovery.
As both HRQoL and SES are multifaceted and dynamic over the life course potential interventions are complex. It is critical to recognise the structural determinants of health inequality that may lead to this association observed in HRQoL after stroke. The unequal distribution of resources can lead to one particular social group being more vulnerable than the others across the life course. Appreciating the influence of SES over the life course can help us to understand how exposure to low SES may result in lower HRQoL after stroke. For example, to raise a person’s education level is subject to not only their education opportunities, individual circumstances such as family culture and family circumstances, but also social mobility in society. Stroke survivors with low SES may be trapped in “the cycle of deprivation” that is challenging to break to improve their HRQoL.
Our study has several implications. Because education, income and occupation can have similar effects on poststroke HRQoL, strategies that addressing education barriers would improve the access to better paying jobs and therefore increase income level. Our findings provide insights to stroke services, particularly, how community-based rehabilitation support and outpatient clinic could effectively approach to more vulnerable groups. Service planning and delivery should address potential barriers, including improving health literature, such as using plain language, to people with low education level, and providing low-fee or fee-free access for stroke survivors with low income.
There are also implications in research. As only three out of 39 studies were specifically focused on assessing the association between SES and HRQoL, the role of potentially confounding factors is not clear. Within these three SES focused studies, two adjusted for stroke severity. As stroke severity and post-stroke disability are likely to influence HRQoL and limited evidence was currently available, more studies with a focus on SES and HRQoL with the adjustment for stroke severity and clinical factors are needed. Most included studies have excluded patients who were unable to consent, failed to complete the HRQoL assessment, or patients with severe impairment such as aphasia or cognitive impairment. These populations who are likely to have different levels of HRQoL post-stroke to groups currently included should be included in future HRQoL studies [
57]. Although a few studies obtained HRQoL assessment from a person’s primary caregivers, the assessment outcomes from these proxies may differ from direct assessment from the people themselves. It remains challenging to eliminate this kind of selection bias in patient reported outcomes, however, careful investigation of the reasons for people not participating in the evaluation should be included in future studies, along with efforts to use inclusive ways of assessing HRQoL (e.g. aphasia friendly HRQoL tools) to minimise the impact of such bias. In addition, SES can change after a stroke, particularly for measures of income and employment status due to the effects of stroke. Most studies assessed income level and employment status prior to stroke, only one study [
23] specified that SES was measured by current employment status during the interview after stroke. However, the change of SES in relation to HRQoL was not examined in that study. Future studies could also explore how the change of SES before and after stroke affects HRQoL.
Several limitations of this study should be noted. We did not conduct a sub-group analysis with occupation because of variations in measurement. For example, occupation was classified by skill level, [
6] currently working or not, [
20,
47,
51] or based on characteristics of employment. [
8,
9] Only five of the 18 studies with adjustment for potentially important confounders could be included in the meta-analysis. As unadjusted results in observational studies are more likely to be biased, the summary effects of the association combining unadjusted and adjusted estimates may be overestimated. Sub-group analysis with only adjusted studies showed an overall smaller effect size but remained significant. Additionally, the unexplained heterogeneity remained large despite the sub-group analyses being stratified by SES indicators. Factors such as measurement of SES, timepoint of HRQoL assessment post stroke and characteristics of the study populations may have contributed to the heterogeneity. HRQoL is subjective, dynamic and multidimensional, so instruments combined across studies may not reflect all aspects of quality of life, particularly psychological and spiritual aspects. Data extraction and quality assessment were conducted by one reviewer and there might be errors or misclassifications. We minimised this risk by using pre-defined rules in data extraction and quality assessment. In meta-analyses, we have combined high/medium to high SES and medium/low to low SES groups when using the raw data from primary studies. The simplification of these grouping may have lost some precision and richness of the data and potentially some nuance in how different levels of SES is associated with HRQoL. In general, the exposure of low or high SES may generally represent the below average and above average SES populations. We only included studies that incorporated measurement of overall HRQoL, excluding 41 studies having subdomains of HRQoL. SES indicators may be associated with some subdomains of HRQoL, and this association would be missed in this review. Finally, we restricted our review to peer reviewed English publications, which is likely to have excluded some studies from non-English speaking countries. However, the ‘global’ meta-analysis included more than 14 regions showing a good representation of regions across the world.
In this systematic review and meta-analysis, we demonstrate that people in low SES groups had an overall poorer HRQoL after stroke compared with those from high SES group regardless of which SES indicator was used. Future studies exploring the dynamic nature of SES and HRQoL before and after stroke, as well as the factors contributing to lower HRQoL after stroke in people experiencing lower SES, may provide insights into interventions to reduce these differences.
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