Re-creating reality: validation of fresh frozen full cadaver airway training with videolaryngoscopy and bougie FIRST strategy

Tracheal intubation is still the gold standard in often life-saving emergency airway management, despite the availability of alternatives [1, 2]. Since the probability of an unexpected difficult airway is increased in the pre-hospital setting, tracheal intubation must be mastered to a high standard by all clinicians, regardless of the main profession of the emergency personnel and the amount of anesthesiological training that may have been completed [3]. The quality of the airway management provided may be evaluated by the First Pass Success Rate (FPSR), defined as the proportion of properly placed tracheal tubes during the first laryngoscopic attempt. By prioritizing intubation success in the first attempt, complications such as swelling of the neck soft tissues, bleeding of the airway, hypotension, and, above all, hypoxia, may be avoided [4, 5].

The safe mastery of tracheal intubation and permanent maintenance of the skill is particularly challenging for non-anesthesiologists, since a minimum number of intubations (100–200 intubations) or a minimum duration of further training in anesthesiology or other emergency subspecialties is required to reach an acceptable level of expertise [6‐9]. At the same time, it may be difficult for pre-hospital clinicians to get the exposure needed to maintain their skills in clinical procedures such as tracheal intubations, solely from their pre-hospital work [10, 11].

Various individual measures or a combination of individual measures can increase FPSR in emergency airway management [12, 13]. Videolaryngoscopy appears to augment laryngeal visualization [14‐17]. Furthermore the use of a bougie-first strategy can achieve up to 14% improved FPSR in patients with difficult airways [18, 19] Standardized positioning maneuvers considering cervical spine protection, such as raising the upper body by 25° (ramping) and elevating the head can further increase laryngeal visibility [20‐24]. Selective manipulation of the soft tissues of the neck during bimanual laryngoscopy can improve laryngeal visualization up to 25% [25, 26].

For advanced airway management training simulation appears to be more effective than non-simulation education (including OR training) [27, 28]. Biological models like fresh frozen cadavers are perceived as more realistic in terms of intubation conditions, learner satisfaction is increased in a cadaver model compared to manikins (Standardized Mean Difference (SMD) 0.79; 95% CI 0.49, 1.08) and outcomes in real clinical settings tend to favor a cadaver model (SMD 0.28; 95%: −0.62, 1.18) [27]. At the same time, it increases user confidence and reduces the duration of airway management [29‐31]. Acquisition of non-time dependent skills may be facilitated by advanced airway manikins (SMD −1.10; 95%, − 2.06, − 0.13) [32]. A combination of both advanced manikins and cadavers is possible [33, 34]. Paramount for learning success is task repetition with intermittent feedback [35, 36].

The combination of 4 h manikin training, a video study, and 2 h cadaver training leads to an equalization of POGO scores between inexperienced and experienced users. These in vitro results showed a correlation of FPSR in real critical care patients [27]. The POGO score indicates the estimated percentage of glottis opening visualized during laryngoscopy by the clinician [37, 38]. By purposefully manipulating the cadaver, it is possible to mimic prehospital intubation conditions and train operators accordingly. By using Peyton´s four-step-approach for teaching manual skills including skill deconstruction to the smallest teachable unit (micro-teaching), providers are able to go through different stages of skill acquisition in a compressed way, which finally enables training in the form of deliberate practice [39‐42].

Equipping local HEMS with VL for the first time while employing clinicians with limited airway management experience made the development of an effective training concept necessary integrating VL.

Our first hypothesis is that the proposed combination of individual techniques to improve intubation conditions will allow a high FPSR for the non-anesthesiology trained user (less than 100 intubations in the operating room setting) in a realistic cadaver model. Secondly, we hypothesize that FPSR, the duration of intubation, and the POGO scores between experienced users (trauma surgery fellows and HEMS physicians) and NOVICES (trauma surgery residents) would converge over the course of training and would, over time, no longer differ significantly. Third, the present fresh frozen cadaver model would show a high correlation with real pre-hospital intubation conditions.

Baseline data of the NOVICES and HEMS group regarding professional experience and intubation skills significantly differ as expected (Table 1).

In the CONTROL scenario, testing the main hypothesis, the FPSR and achieved C&L grade of the HEMS group increased significantly compared to the pre-hospital patient reference group BASELINE (HEMS FPSR 100%, absolute difference: 23%, p ≤ 0.001; median C&L 1, IQR 1–2, p = 0.018). Compared to BASELINE the use of videolaryngoscopy, bougie, and the application of positioning techniques required significantly more time (median HEMS 34.0 s, IQR 28.3–47.5, absolute difference: 13.0 s, p = 0.045) (Table 2).

For the secondary hypothesis of converging intubation performance (FPSR, POGO, duration of intubation) a group comparison between NOVICES and HEMS of the CONTROL scenario, in which all maneuvers were performed independently by the participants, found no significant differences. In the OLD scenario as standard of care the HEMS group still scored higher in intubation conditions (C&L grade, POGO) without being statistically significant. While FPSR or intubation duration already demonstrated no significant difference. The quality of intubation performance in OLD was rated significantly lower by instructors in the NOVICE group (NOVICE 7.0 (IQR 5.25–8.00), HEMS 8.0 (7.0–10.0), p < 0.001), while in CONTROL no difference was found. The data of the four study scenarios are shown in Table 2.

In order to verify the third hypothesis, a comparison of the intubation characteristics of the two FFC groups and the pre-hospital patient reference group (BASELINE) showed no statistically significant differences between the 3 groups (Table 3). Accordingly, There was no significant difference of intubation performance by the HEMS group between the OLD scenario and the BASELINE data (FPSR n = 47 (77%, p = 0.317, C&L grade median 2 (IQR 1–2, p = 0.124), duration of intubation median 25.5 s (IQR 18.5–45.0, p = 0.994). The perceived realism of the FFC was rated higher by the HEMS group (NOVICES median 4.0 (IQR 3.6–4.0), HEMS median 5.0 (IQR 5.0–5.0), p < 0.001).

For the NOVICES group, there was no significant correlation between the number of intubations performed on a real patient prior to the start of training and FPSR in the OLD and CONTROL scenarios (OLD Rho 0.178, p = 0.172; CONTROL Rho − 0.212, p = 0.105); this correlation is also absent in the HEMS group (OLD Rho − 0.104, p = 0.430; CONTROL Rho − 0.094, p = 0.473).

In this study, a combination of positioning maneuvers and the use of technical devices i.e. videolaryngoscopy and bougie FIRST strategy succeeded in significantly increasing the FPSR by at best 23% in a fresh frozen cadaver model.

As shown by Driver et al. in a single center randomized controlled trial at an emergency department in Minneapolis, the bougie FIRST strategy alone is a suitable tool to significantly increase the FPSR in adult emergency patients [18]. Among 380 patients with at least 1 difficult airway characteristic (body fluids obscuring the laryngeal view, airway obstruction or edema, obesity, short neck, small mandible, large tongue, facial trauma, or the need for cervical spine immobilization) first-attempt intubation success was higher in the bougie group (96%) than in the endotracheal tube + stylet group (82%) (absolute difference, 14% [32]). VL used by US emergency physicians in the 3rd year of training raises FPSR up to 90% compared to DL (FPSR 73%). Therefore VL is recommended as the primary intubating device for patients with difficult airway characteristics [45]. A RCT in in-hospital inducation of anaesthesia showed a higher FPSR in VL compared to DL ((93% vs. 84%), p = 0.026), with at the same time better visualization of the vocal cord level (C&L I/II: 93% vs. 81%, p < 0.01) [46]. POGO scores also improved in our study by using VL. Those high FPSR rates could be reached in different HEMS settings with both an anesthesiological or trauma surgical specialization by using videolaryngoscopy as first line device [16, 47].

A better visualization of the vocal cord level results in higher FPSR rates in patients with cervical immobilization representing a difficult airway characteristic what is relevant for a trauma patient population [48].

Improving visualization and adjustability of the vocal cords by using VL may be at the expense of a longer intubation time compared to DL (46 vs. 33 s, absolute difference 13 s, p < 0.001) [46]. The combination of VL and bougie FIRST strategy used in the study also required significantly more time (absolute difference 13.0 s) compared to DL, but participants were not trained in VL use before. The clinical significance of this difference must be questioned when considering the time to desaturation demonstrated in previous studies. For example, saturations < 90% rarely occur after 3 min of preoxygenation with an intubation time of less than 60 s [49].

Comparable results (FPSR, POGO, intubation time) were achieved by both groups regardless of previous intubation experience. Numerous studies on real life patients have shown the correlation of the FPSR with the number of intubations already performed by the provider. The learning curve starts flattening only after 25–30 intubations [6, 50]. The BOAH course concept therefore seems suitable to move the first part of this learning curve from a real life scenario into the safe and reproducible laboratory environment providing a starting point for the necessary real-life experience. Especially for non- anesthesiological trained users, this training environment offers the conditions for rapid task repetition and gain of experience with devices like the videolaryngoscope and the bougie.

The cadaver model successfully reproduced the airway characteristics of a pre-hospital patient group cared for by HEMS in the lab setting. Thereby, FPRS, duration of intubation, and C&L grade showed no significant differences between the lab setting and the pre-hospital setting.

In a fresh frozen cadaver model, a combination of evidenced based airway management techniques results in high FPSR and POGO rates of non-anesthesiological trained users. Using teaching concepts like deliberate practice, immediate video-feedback-practice loops, 1:1 teaching with a mentor enables single technique mastery regardless of previous provider experience. The cadaver model successfully reproduced airway characteristics of a pre-hospital patient reference group cared for by HEMS. The BOAH concept can move the early learning curve of emergency intubation training from a real life scenario to a controlled high-volume laboratory setting and can therefore be used in the early stages of airway training.