Introduction
Materials and methods
Patient population
Scan indication | Number of patients | Age distribution* | BMI* | ||||||
---|---|---|---|---|---|---|---|---|---|
Total | Male | Female | All | Male | Female | All | Male | Female | |
Breast Cancer | 1 | – | 1 | 51 | – | 51 | 28.4 | – | 28.4 |
Cancer of unknown primary origin | 3 | 1 | 2 | 68 | 87 | 58 [57–59] | 29.7 [22.2–37.6] | 22.2 | 33.65 [29.7–37.6] |
Gastro–intestinal cancer | 21 | 17 | 4 | 67 [29–83] | 67 [29–83] | 64 [44–75] | 26.2 [16.8–40.6] | 26.5 [16.8–40.6] | 20.8 [18.9–27.6] |
Head & Neck cancer | 12 | 8 | 4 | 64.5 [32–81] | 66 [53–81] | 62.5 [32–66] | 24.6 [22.6–37.4] | 25.7 [22.8–36.5] | 22.9 [22.6–37.4] |
Infection & Inflammation | 13 | 8 | 5 | 64 [21–89] | 58.5 [27–78] | 64 [21–89] | 24.2 [20.7–36.8] | 23.9 [20.7–36.8] | 24.6 [21.9–26.4] |
Lung Cancer | 97 | 52 | 45 | 74 [42–89] | 75 [42–86] | 72 [42–89] | 25.8 [14.5–44.4] | 26 [14.5–42.6] | 25.7 [16–44.4] |
Lymphoma | 23 | 14 | 9 | 67 [18–80] | 62 [39–78] | 67 [18–80] | 25.3 [19.4–45.4] | 27.2 [19.8–45.4] | 23.7 [19.4–31.6] |
Melanoma | 10 | 5 | 5 | 62.5 [52–81] | 64 [57–79] | 60 [52–81] | 27 [23.1–31.3] | 27.1 [25.5–28.7] | 26.8 [23.1–31.3] |
NET | 1 | 1 | – | 68 | 68 | – | 25.5 | 25.2 | – |
Sarcoma | 1 | – | 1 | 63 | – | 63 | 32.5 | – | 32.5 |
Uro–genital cancer | 18 | 2 | 16 | 65 [26–87] | 63 [59–67] | 66 [26–87] | 25.8 [20.5–47.7] | 33.5 [32.2–34.7] | 24.2 [20.5–47.7] |
Total | 200 | 108 | 92 | 68 [18–89] | 70 [27–87] | 70 [18–89] | 25.6 [14.5–47.7] | 26.1 [14.5–45.4] | 25.4 [16–47.7] |
Data acquisition and image reconstruction
Clinical feasibility of PET scanning using belt-gated respiratory gating
Semi-quantitative image analysis
Visual image analysis and clinical evaluation
Evaluation of lymphoma patients using the Deauville criteria
Statistical analysis
Results
Clinical feasibility
Semi-quantitative analysis
Lesion | UG | BG | DDG |
---|---|---|---|
SUVmax | 8.29 [2.86–45.4] | 9.50 [2.88–47.3] | 9.43 [3.01–47.1] |
P value to UG | < 0.0001 | < 0.0001 | |
P value to BG | 0.98 | ||
SUVmean | 3.77 [1.19–12.8] | 4.04 [1.2–13] | 4.07 [1.19–12.9] |
P value to UG | < 0.0001 | < 0.0001 | |
P value to BG | 0.02 | ||
Metabolic volume (mL) | 4.28 [0.03–317] | 3.81 [0.05–313] | 3.77 [0.05–312] |
P value to UG | < 0.0001 | < 0.0001 | |
P value to BG | 0.006 |
Liver | UG | BG | DDG |
---|---|---|---|
SUVmax | 3.59 [2.18–6.21] | 3.71 [2.16–6.48] | 3.73 [2.33–4.38] |
P value to UG | < 0.0001 | < 0.0001 | |
P value to BG | 0.91 | ||
SUVmean | 2.23 [1.33–2.94] | 2.21 [1.33–2.94] | 2.21 [1.33–3.08] |
P value to UG | < 0.0001 | < 0.0001 | |
P value to BG | 0.64 |