Introduction
Patients and methods
Study design
Patients
Definition of asthma diagnosis
*Definition of stable clinical condition
Study aims
Primary aim
Secondary aim
Variables analyzed
Statistical analysis
Sample size
Statistical analysis
Results
Patients’ characteristics
Variables | Total population (n = 1,286) | Development population (n = 855) | Validation population (n = 431) |
P value
|
---|---|---|---|---|
Age in years, median, (IQR)
|
38 (27–50)
|
37 (27–48)
|
37 (26–50)
|
0.502
|
Women (%)
|
60.3
|
60.6
|
59.6
|
0.741
|
Smoking habit (%):
| ||||
Smoker
|
12.8
|
13.0
|
12.4
|
0.322
|
Non-smoker
|
69.1
|
67.9
|
71.7
| |
Ex-smoker
|
18.0
|
19.1
|
15.9
| |
Environment (%):
| ||||
Urban
|
67.4
|
68.8
|
64.8
|
0.154
|
Rural
|
32.6
|
31.2
|
35.2
| |
Years since asthma diagnosis: Median, (IQR)
|
10 (4.4 - 20)
|
10 (4.5-20)
|
10 (4–19)
|
0.830
|
Rhinitis (% patients)
|
91.7
|
93.2
|
90.1
|
0.780
|
Lung function
| ||||
FEV
1
mean% (SD)
|
88.3 (18.8)
|
88.5 (19)
|
88.0 (18.6)
|
0.642
|
FVC mean% (SD)
|
95.5 (19.02)
|
95.4 (19.4)
|
95.7 (18.3)
|
0.813
|
FEV
1
/FVC mean% (SD)
|
76.7 (13.07)
|
77.2 (13.8)
|
75.9 (11.5)
|
0.08
|