Background
Methods
Study design
Measures at 12 months
Statistical analysis
Results
Baseline characteristics
Variables | Thrombolysis (%) | Without (%) | p |
---|---|---|---|
Patients included | 33 | 55 | |
Gender*
|
0.008
| ||
- Men
| 24 (72.7) | 32 (58.2) | |
- Women
| 9 (27.3) | 23 (41.8) | |
Age, average (range)#
| 73.6 (61-85) | 77.2 (65-91) |
0.025
|
Living situation*
| |||
- Living alone
| 7 (21.2) | 30 (55.5) |
0.003
|
- Living with a partner
| 26 (78.8) | 25 (45.5) | |
Brain hemisphere*
| |||
- Left side
| 20 (39.4) | 16 (29.1) |
0.007
|
- Right side
| 13 (60.6) | 34 (61.8) | |
- Unknown
| 5 (9.1) | ||
NIHSS, average (range)#
| 9.97 (3-27) | 2.6 (0-6) |
<0.001
|
Length of hospital stay in days | 7 | 7 | 1.000 |
Risk factors present before stroke/History*
| 1 (3.0) | 6 (10.9%) | 0.248 |
- No risk factors
| 23 (69.7) | 27 (49.1) | 0.076 |
- Hypertension
| 13 (39.4) | 6 (10.9) |
0.003
|
- Hypercholesterolemia
| 4 (12.1) | 12 (21.8) | 0.392 |
- Diabetes
| 9 (27.3) | 16 (29.1) | 1.000 |
- Smoking
| 9 (27.3) | 14 (25.5) | 1.000 |
- Ischemic heart disease
| 9 (27.3) | 13 (23.6) | 0.801 |
- Stroke/TIA
| 7 (21.2) | 5 (9.1) | 0.122 |
- Atrial fibrillation
| 1 (3.0) | 2 (3.6) | 1.000 |
Health-related quality of life (RAND-36)
Rand-36 | Thrombolysis | Without | |
---|---|---|---|
Median (range), [95% CI]
|
Median (range), [95% CI]
|
p
*
| |
Physical functioning
| 65 (0-100) [50-85] | 62.5 (5-100) [55-80] | 0.762 |
Social functioning
| 100 (0-100) [75-100] | 100 (25-113) [75-100] | 0.716 |
Role limitations – physical
| 50 (0-100) [25-75] | 75 (0-100) [50-75] | 0.346 |
Role limitations – emotional
| 100 (0-100) [100-100] | 100 (0-100) [100-100] | 0.467 |
Mental Health
| 88 (20-100) [80-96] | 80 (16-100) [72-84] |
0.024
|
Vitality
| 85 (5-100) [65-90] | 65 (15-95) [60-70] |
0.024
|
Bodily Pain
| 89.8 (0-100) [69.4-100] | 89.8 (12-100) [69.4-100] | 0.892 |
General Health
| 65 (0-100) [55-80] | 65 (0-100) [55-75] | 0.427 |
HRQOL | Activities | p#
|
---|---|---|
Physical functioning
|
Housekeeping
| 0.374 |
Physical activity
| 0.465 | |
Hobbies
| 0.327 | |
Visiting
| 0.615 | |
Reading
| 0.077 | |
Social functioning
|
Housekeeping
| 0.145 |
Physical activity
| 0.308 | |
Hobbies
| 0.264 | |
Visiting
| 0.077 | |
Reading
| 0.227 | |
Role limitations – physical
|
Housekeeping
| 0.469 |
Physical activity
| 0.868 | |
Hobbies
| 0.062 | |
Visiting
| 0.397 | |
Reading
| 0.657 | |
Role limitations – emotional
|
Housekeeping
| 0.678 |
Physical activity
|
0.011
| |
Hobbies
| 0.877 | |
Visiting
| 0.089 | |
Reading
|
0.020
| |
Mental health
|
Housekeeping
| 0.076 |
Physical activity
| 0.057 | |
Hobbies
| 0.638 | |
Visiting
| 0.583 | |
Reading
| 0.089 | |
Vitality
|
Housekeeping
| 0.518 |
Physical activity
| 0.104 | |
Hobbies
| 0.602 | |
Visiting
| 0.806 | |
Reading
|
0.033
| |
Bodily pain
|
Housekeeping
| 0.498 |
Physical activity
| 0.355 | |
Hobbies
| 0.164 | |
Visiting
| 0.898 | |
Reading
| 0.200 | |
General health
|
Housekeeping
| 0.386 |
Physical activity
| 0.221 | |
Hobbies
| 0.053 | |
Visiting
| 0.880 | |
Reading
| 0.560 |
Level of dependence according to the barthel index
Variables | Thrombolysis | Without | ||||||
---|---|---|---|---|---|---|---|---|
N
|
Median BI (range)
|
p*
|
N
|
Median BI (range)
|
p*
|
p
#
| ||
Gender
2
| Male | 24 | 20 (4-20) | 0.310 | 23 | 20 (12-20) | 0.155 | 0.227 |
Female | 9 | 19 (9-20) | 32 | 19 (13-20) | ||||
Social situation
2
| Living alone | 7 | 18 (18-20) | 0.355 | 30 | 19.5 (13-20) | 0.405 | 0.419 |
Living with partner | 26 | 20 (4-20) | 23 | 20 (12-20) | ||||
Stroke location
2
| Left side | 13 | 20 (9-20) | 0.561 | 34 | 20 (13-20) | 0.851 | 0.096 |
Right side | 20 | 20 (4-20) | 16 | 19.5 (12-20) | ||||
Unknown | 0 | 5 | 20 (18-20) | |||||
Housekeeping
1
| More | 1 | 20 (20-20) |
0.005
| 5 | 20 (18-20) |
<0.001
| 0.612 |
As much as before | 21 | 20 (18-20) | 25 | 20 (13-20) | ||||
Less | 7 | 20 (8-20) | 16 | 18 (15-20) | ||||
Quit | 4 | 9 (4-18) | 8 | 17 (12-19) | ||||
Physical activity
1
| More | 1 | 20 (20-20) | 0.107 | 2 | 20 (20-20) |
0.003
| 0.139 |
As much as before | 16 | 20 (18-20) | 18 | 20 (16-20) | ||||
Less | 15 | 20 (8-20) | 30 | 20 (12-20) | ||||
Quit | 1 | 4 (4-4) | 4 | 14 (12-17) | ||||
Hobbies
1
| More | 0 |
0.005
| 1 | 20 (20-20) | 0.662 | 0.866 | |
As much as before | 17 | 20 (18-20) | 34 | 20 (13-20) | ||||
Less | 7 | 20 (18-20) | 18 | 20 (12-20) | ||||
Quit | 9 | 18 (4-20) | 1 | 18 (18-18) | ||||
Visiting
1
| More | 1 | 20 (20-20) | 0.058 | 0 |
0.001
|
0.002
| |
As much as before | 25 | 20 (9-20) | 37 | 20 (15-20) | ||||
Less | 5 | 20 (8-20) | 14 | 18.5 (13-20) | ||||
Quit | 2 | 6.5 (4-9) | 3 | 15 (12-17) | ||||
Vacation
| More | 0 | 0.182 | 2 | 20 (20-20) |
0.007
|
0.001
| |
As much as before | 18 | 20 (9-20) | 25 | 20 (13-20) | ||||
Less | 9 | 20 (9-20) | 12 | 20 (18-20) | ||||
Quit | 6 | 18.5 (4-20) | 15 | 17 (12-20) | ||||
Experienced quality of life
2
| Increased | 2 | 20 (20-20) | 0.107 | 0 | 0.505 | 0.169 | |
The same | 16 | 20 (18-20) | 37 | 20 (13-20) | ||||
Diminished | 15 | 19 (4-20) | 17 | 19 (12-20) |
Mood disorder (HADS)
Daily occupations
Daily Occupations | Thrombolysis (%) | No Thrombolysis (%) | p* | |
---|---|---|---|---|
Physical exercise
| More | 3.0 | 8.8 | 0.434 |
The same | 63.6 | 43.9 | ||
Less | 21.2 | 28.1 | ||
Quit | 12.1 | 14.0 | ||
Housekeeping
| More | 3.0 | 3.5 | 0.546 |
The same | 48.5 | 31.6 | ||
Less | 45.5 | 52.6 | ||
Quit | 3.0 | 7.0 | ||
Hobbies
| More | 0.0 | 1.8 |
0.002
|
The same | 51.5 | 59.6 | ||
Less | 21.2 | 31.6 | ||
Quit | 27.3 | 1.8 | ||
Visiting
| More | 3.0 | 0.0 | 0.463 |
The same | 75.8 | 64.9 | ||
Less | 15.2 | 24.6 | ||
Quit | 6.1 | 5.3 | ||
Holidays
| More | 0.0 | 3.5 | 0.544 |
The same | 54.5 | 43.9 | ||
Less | 27.3 | 21.1 | ||
Quit | 18.2 | 26.3 | ||
Reading
| More | 3.0 | 3.5 | 0.398 |
The same | 69.7 | 77.2 | ||
Less | 24.2 | 10.5 | ||
Quit | 3.0 | 3.5 |