Background
Methods
Clinicopathological Review and IHC
Statistical Analysis
Results
Clinical Feature | No. of cases Non-TNP | No. of cases TNP | Odds Ratio [95% CI] | P-value* | |
---|---|---|---|---|---|
Center
|
VGH
| 228 | 36 | ||
JGH
| 165 | 27 | 1.04 [0.61; 1.77] | 0.89 | |
Age at diagnosis
|
25–49 years
| 116 | 32 | ||
50–95 years
| 277 | 31 | 0.41 [0.24; 0.70] | 0.001 | |
Histological grade
|
Grade 1
| 120 | 4 | ||
Grade 2
| 193 | 15 | 2.33 [0.76; 7.19] | 0.15 | |
Grade 3
| 68 | 40 | 17.65 [6.05; 51.45] | <0.0001 | |
Missing
| 12 | 4 | |||
Tumor size
|
0–2 cm
| 161 | 18 | ||
2.01–15 cm
| 217 | 45 | 1.85 [1.04; 3.32] | 0.04 | |
Missing
| 15 | 0 | |||
Lymph node status
|
Negative
| 205 | 41 | ||
Positive
| 149 | 13 | 0.44 [0.23; 0.84] | 0.01 | |
Missing
| 39 | 9 | |||
Hormonal Treatment
|
None
| 219 | 49 | ||
Yes
| 161 | 11 | 0.31 [0.15; 0.61] | 0.0003 | |
Missing
| 13 | 3 | |||
Chemotherapy
|
None
| 279 | 35 | ||
Yes
| 108 | 26 | 1.92 [1.10; 3.34) | 0.02 | |
Missing
| 6 | 2 |
3 years | 10 years | ||||
---|---|---|---|---|---|
Variable | Definition | RR (95% CI) |
P
| RR (95% CI) |
P
|
Center
| VGH | 1. | 1. | ||
JGH | 0.67 [0.35; 1.31] | .25 | 0.76 [0.51; 1.13] | .17 | |
Age of diagnosis
| < 50 years | 1. | 1. | ||
≥ 50 years | 1.10 [0.55; 2.16] | .79 | 0.97 [0.66; 1.44] | .89 | |
Histological grade*,
§
| 1 | 1. | 1. | ||
2 | 2.62 [0.88; 7.80] | .08 | 1.63 [0.97; 2.73] | .06 | |
3 | 5.47 [1.84; 16.2] | .002 | 2.37 [1.36; 4.11] | .002 | |
Tumor Size
§
| < 2 cm | 1. | 1. | ||
≥ 2 cm | 3.22 [1.42; 7.32] | .005 | 2.82 [1.78; 4.46] | .0001 | |
Lymph nodes
§
| No | 1. | 1. | ||
Yes | 2.78 [1.37; 5.65] | .005 | 2.21 [1.46; 3.32] | .0002 |
Univariate | Full Multivariate | Parsimonious | ||||||
---|---|---|---|---|---|---|---|---|
Model | Variable | RR (95% CI) |
P
| RR (95% CI) |
P
| RR (95% CI) |
P
| |
Model 1 | CK5/6+ and/or EGFR+ | No | 1. | 1. | ||||
Yes | 2.24 [1.14; 4.39] | 0.02 | 1.20 [0.50; 2.85] | 0.68 | not present | |||
TNP | No | 1. | 1. | 1. | ||||
Yes | 4.06 [2.11; 7.82] | 0.0001 | 3.42 [1.37; 8.49] | 0.008 | 4.40 [2.23; 8.69] | 0.0001 | ||
Model 2 | PR | No | 1. | 1. | ||||
Yes | 0.43 [0.23; 0.81] | 0.009 | 0.70 [0.34; 1.45] | 0.34 | not present | |||
CBP | No | 1. | 1. | 1. | ||||
Yes | 3.73 [1.88; 7.39] | 0.0002 | 3.13 [1.26; 7.77] | 0.01 | 4.29 [2.12; 8.68] | 0.0001 | ||
Model 3 | ER- HER2- | No | 1. | 1. | 1. | |||
Yes | 4.39 [2.34; 8.23] | 0.0001 | 4.82 [1.95; 11.9] | 0.0006 | 5.38 [2.77; 10.5] | 0.0001 | ||
PR | No | 1. | 1. | |||||
Yes | 0.43 [0.23; 0.81] | 0.009 | 0.82 [0.38; 1.76] | 0.61 | not present | |||
CK5/6+ and/or EGFR+ | No | 1. | 1. | |||||
Yes | 2.24 [1.14; 4.39] | 0.02 | 0.99 [0.42; 2.34] | 0.98 | not present |
Univariate | Full Multivariate | Parsimonious | ||||||
---|---|---|---|---|---|---|---|---|
Model | Variable | RR (95% CI) |
P
| RR (95% CI) |
P
| RR (95% CI) |
P
| |
Model 1 | CK5/6+ and/or EGFR+ | No | 1. | 1. | 1. | |||
Yes | 2.00 [1.33; 3.02] | 0.0009 | 1.95 [1.18; 3.21] | 0.009 | 1.92 [1.27; 2.89] | 0.002 | ||
TNP | No | 1. | 1. | |||||
Yes | 1.71 [1.05; 2.78] | 0.03 | 0.96 [0.51; 1.79] | 0.89 | not present | |||
Model 2 | PR | No | 1. | 1. | 1. | |||
Yes | 0.59 [0.40; 0.85] | 0.005 | 0.64 [0.42; 0.98] | 0.04 | 0.62 [0.42; 0.92] | 0.02 | ||
CBP | No | 1. | 1. | |||||
Yes | 1.72 [1.06; 2.80] | 0.03 | 1.18 [0.64; 2.17] | 0.60 | not present | |||
Model 3 | ER- HER2- | No | 1. | 1. | 1. | |||
Yes | 1.96 [1.30; 2.97] | 0.002 | 1.41 [0.80; 2.49] | 0.24 | 1.64 [0.99; 2.70] | 0.05 | ||
PR | No | 1. | 1. | |||||
Yes | 0.59 [0.40; 0.85] | 0.005 | 0.77 [0.49; 1.20] | 0.24 | not present | |||
CK5/6+ and/or EGFR+ | No | 1. | 1. | 1. | ||||
Yes | 2.00 [1.33; 3.02] | 0.0009 | 1.54 [0.92; 2.58] | 0.10 | 1.69 [1.04; 2.74] | 0.03 |