Background
Methods
Samples
blood donors | male | female |
---|---|---|
lung cancer patients
| ||
number | 9 | 8 |
average age | 67 | 61 |
healthy subjects
| ||
number | 7 | 12 |
average age | 43 | 35 |
sample | tumor type | clinical stage |
---|---|---|
463 | adenocarcinoma | T2N0 |
464 | typical carcinoid | T2N0 |
468 | adenocarcinoma | T2N0 |
469 | adenocarcinoma | T2N2 |
485 | adenocarcinoma | T2N0 |
490 | adeno squamous carcinoma | T2N0 |
492 | adenocarcinoma | T2N0 |
503 | squamous cell carcinoma | T1N0 |
507 | squamous cell carcinoma | T4Nx |
508 | squamous cell carcinoma | T2aN0 |
509 | squamous cell carcinoma | T2N0 |
513 | bronchoalveolar carcinoma | T3N0 |
514 | adenocarcinoma | T2N2 |
517 | squamous cell carcinoma | T2N0 |
523 | squamous cell carcinoma | T2N0 |
524 | squamous cell carcinoma | T3N2 |
525 | adenocarcinoma | T1N0 |
miRNA extraction and microarray screening
Statistical analysis
Results
miRNA experiments
ruling out the influence of age and gender
single deregulated miRNAs
Diagnostic value of miRNA biomarkers
Evaluating complex fingerprints
miRNA | median cancer | median control | Fold change | Log(FC) | t-test adj |
---|---|---|---|---|---|
hsa-miR-126 | 606,46 | 3428,42 | 0,18 | -1,73 | 3,43E-05 |
hsa-miR-423-5p | 6795,89 | 3976,97 | 1,71 | 0,54 | 0,000978034 |
hsa-let-7d | 6795,89 | 13307,74 | 0,51 | -0,67 | 0,002715951 |
hsa-let-7i | 4106,11 | 6349,31 | 0,65 | -0,44 | 0,002715951 |
hsa-miR-15a | 3428,42 | 5944,79 | 0,58 | -0,55 | 0,008784487 |
hsa-miR-22 | 7978,5 | 3868,5 | 2,06 | 0,72 | 0,008784487 |
hsa-miR-98 | 322,44 | 1440,75 | 0,22 | -1,5 | 0,008784487 |
hsa-miR-19a | 420,06 | 1 | 420,06 | 6,04 | 0,015204977 |
hsa-miR-20b | 1118,35 | 2947,83 | 0,38 | -0,97 | 0,015204977 |
hsa-miR-324-3p | 1221,94 | 700,5 | 1,74 | 0,56 | 0,015204977 |
hsa-miR-574-5p | 108,56 | 30,22 | 3,59 | 1,28 | 0,015204977 |
hsa-miR-195 | 2575,72 | 4462,58 | 0,58 | -0,55 | 0,018313065 |
hsa-miR-25 | 12517,64 | 7639,53 | 1,64 | 0,49 | 0,018313065 |
hsa-let-7e | 1297,51 | 2947,83 | 0,44 | -0,82 | 0,019691385 |
hsa-let-7c | 5660,31 | 8969,72 | 0,63 | -0,46 | 0,019946719 |
hsa-let-7f | 5382,15 | 9746,17 | 0,55 | -0,59 | 0,019992878 |
hsa-let-7a | 6795,89 | 12517,64 | 0,54 | -0,61 | 0,022999135 |
hsa-let-7g | 3428,42 | 6795,89 | 0,5 | -0,68 | 0,023591848 |
hsa-miR-140-3p | 9312,5 | 4621,29 | 2,02 | 0,7 | 0,024644601 |
hsa-miR-339-5p | 312,11 | 12,44 | 25,08 | 3,22 | 0,025550318 |
hsa-miR-361-5p | 606,46 | 53 | 11,44 | 2,44 | 0,030845953 |
hsa-miR-1283 | 2,33 | 22,22 | 0,11 | -2,25 | 0,03712987 |
hsa-miR-18a* | 1040,44 | 119,89 | 8,68 | 2,16 | 0,04393972 |
hsa-miR-26b | 1085,22 | 2058,85 | 0,53 | -0,64 | 0,044122011 |