Risk factors for early recurrence after inguinal hernia repair

After primary hernia repair up to 10% recurrences are reported[1]. Mesh technique and the surgeons' experience are important factors to obtain good results. Nevertheless, the risk for hernia recurrence increases from repair to repair[2]. The question is if patients with more than one recurrence are not treated sufficiently or if their recurrences are based on disturbances of the extracellularmatrix.

Family history is an important predictors for the development of inguinal hernias[3] as well as for hernia recurrence[4] and indicates that genetic factors play a role for disease manifestation at least in a subgroup of hernia patients. Especially collagen genes are suspicious genes because studies on the biology of hernia formation suggest that disturbances in collagen metabolism contribute to high recurrence rates[5, 6]. A decreased ratio of type I/III collagen is reported for inguinal, incisional and especially for recurrent hernias [7‐10]. The collagen composition is of great importance not only for tissue integrity and resistance to tensile stress but also for sufficient tissue remodelling after tissue injury and disturbances of collagen expression could explain high recurrence rates [11‐13]. Recently, type III collagene gene (Col3A1) polymorphisms were identified for patients with gastroesophageal reflux disease and hiatal hernias[14]. Northern blot as well as real time PCR analyses have shown changes in the expression of collagen genes [15‐18].

Disturbed collagen expression can not only be caused by genetic alterations but also by exogenous factors, e.g. smoking and ascorbic acid deficiency. Moreover, it might be anticipated from diseases with gradual or late onset in life, e. g. atherosclerosis or hypertension, that the coincidence of multiple risk factors determines an individual's susceptibility. For the onset of inguinal hernia disease, smoking, comorbidity and age are established risk factors [19‐21].

This study evaluates if family history has impact on the manifestation of hernia recurrence. We investigated patients having more than one recurrence where the primary and secondary hernia repair failed. Differences in the risk profile of primary and recurrent inguinal hernia patients might help to identify 'biological subgroups' of patients at risk. Referring to the European Hernia Society guidelines the identification of biological subgroups can be of importance to develop a tailored approach for hernia surgery[22].

Although age distribution was equal in both groups patients with family history had their primary hernia as well as their recurrence earlier. The onset of primary hernia was 41 years for patients with family history (range 18-64 years) and 48 years for patients without family history of hernia disease (range 18 -74 years, p = 0.04, table 2). Hernia recurrence occurred about 7 years earlier in patients with family history (46 versus 53 years p = 0.04, table 2).

A significant correlation could be detected between onset of primary hernia and the disease-free interval (Pearson's correlation coefficient r = -0.518, p = 0.01, Figure 1). The older the patients were at onset, the earlier they had a hernia recurrence.

Additionally, primary hernias occurred significantly earlier in smokers (p = 0.006) but not in patients with coronary heart disease or hypertension (Table 3).

Family history or smoking had no impact on the overall recurrence rate (p = 0.82 and p = 0.83, table 4). Coronary heart disease and hypertension were predictive factors for high recurrence rates (p = 0.001 and p = 0.03, table 4). These data correlated with anti-hypertensive medication and ACE inhibitors (data not shown).

The new finding of our study is that family history is not only a risk for primary hernias but also for hernia recurrence. In the present study 44% of the analyzed recurrent hernia patients have a family history of hernia disease. Lau et al. observed a rate of about 20% of patients with affected relatives developing primary inguinal hernias[23]. The importance of family history is reflected by a significantly earlier onset of primary as well as recurrent hernia disease. This study was based on the assumption that hernias have a genetic background. Several studies hint on collagen genes as candidate genes[18]. Collagens are very important for a sufficient wound healing. Family history as a risk factor for early recurrence would support the hypothesis that collagen gene or genes associated to collagen metabolism play a role for hernia disease.

Though the incidence of family history is considerably higher in recurrent hernia patients than in patients with primary hernias we could not detect any differences of recurrence rates between patients with or without family history. However, we have to consider an age-dependent recall bias as recurrence rates continuously increase with age. In our cohort more than 5 recurrences could be observed exclusively for patients that were older than 50 years and we have to expect a rise of recurrence rates for younger patients. Interestingly, recurrence rates were influenced by coronary heart disease and hypertension as well as by the corresponding medication. Regarding the fact that patients with coronary heart disease are significantly older, the increased recurrence rate can result from a prolonged observation period for these patients rather than from the coronary heart disease. However, coronary heart disease is known to be associated with disturbed collagen metabolism[24].

As expected hernia recurrence was influenced by patients' age. We found that the younger the patients were at onset the later they had a hernia recurrence. The age dependent manifestation of recurrence can be an argument for a tailored approach, especially if we think of complications due to mesh implantation.

The described risk factors are known to have impact on collagen regulation at different levels. Family history has to be correlated to a disturbed gene regulation whereas smoking induces a lack of ascorbic acid and hinders fibrillogenesis. The abnormal collagen expression in tissue samples of hernia patients results from the interactions between these factors. Comparing our results with those obtained from literature it becomes obvious that family history and age are risk factors for both, primary and recurrent inguinal hernia disease. Indeed, our study is limited to 75 patients with re-recurrent hernias. But in contrast to patients with primary hernias, smoking could not be identified as a risk factos for re-recurrent hernias. As a consequence different molecular pathways have to be assumed and especially genetic analyses have to be performed in carefully defined subsets of patients. Though an altered collagen composition is known, therapeutic approaches for hernias are still restricted to reinforcement of the abdominal wall. The identification of susceptible genes could permit causative treatment options as realized for the treatment of aortic aneurysm by distinctive blockage of gene transcription in animal models[25]. Meshes can be used as carrier systems for potential drug treatment. Current research may focus on the identification of patients at risk for recurrence or the prevention of hernia recurrence by improving wound healing.

In summary, our data reveal an increased incidence of family history for recurrent hernia patients when compared with primary hernia patients. Patients with a family history have their primary hernias as well as their recurrence at younger age then patients without a family history. Though recurrent hernia has to be regarded as a disease caused by multiple factors, a family history may be considered as a criterion to identify the risk for recurrence before the primary operation.