Background
Geographical and socio-economic situation
Malaria in Niger
Rationale
Methods
Study area
Patients and methods
Statistical methods
Ethical issues
Results
Population
3–12 | 13–24 | 24–60 | |||||
---|---|---|---|---|---|---|---|
number n = 103 | % | number n = 103 | % | number n = 50 | % | ||
Dehydration | severe | 8 | (7.8) | 3 | (2.9) | 0 | (0.0) |
mild | 42 | (40.8) | 32 | (31.1) | 16 | (32.0) | |
absence | 46 | (44.7) | 60 | (58.3) | 32 | (64.0) | |
ND | 7 | (6.8) | 8 | (7.8) | 2 | (4.0) | |
Clinical malnutritiona | severe | 4 | (3.9) | 8 | (7.8) | 0 | (0.0) |
mild | 29 | (28.1) | 27 | (26.2) | 9 | (18.0) | |
absence | 53 | (51.5) | 50 | (48.5) | 37 | (74.0) | |
ND | 17 | (16.5) | 18 | (17.5) | 4 | (8.0) | |
Weight / age ratiob | severe | 26 | (25.2) | 33 | (32.0) | 4 | (8.0) |
mild | 30 | (29.1) | 32 | (31.1) | 6 | (12.0) | |
absence | 39 | (37.9) | 30 | (29.1) | 16 | (32.0) | |
ND | 8 | (7.8) | 8 | (7.8) | 24 | (48.0) |
Clinical and biological diagnosis of malaria
Positive blood smear | Negative blood smear | p value | |||
---|---|---|---|---|---|
number/total | (%) | number/total | (%) | ||
CLINICAL SYMPTOMS
| |||||
comaa | 22/77 | (28,6) | 7/64 | (10,9) | p = 0,022 |
impaired consciousnessb | 15/77 | (19,5) | 11/64 | (17,2) | |
convulsionsc | 71/119 | (59,7) | 36/103 | (35,0) | < 0,001 |
digestive disorders | 58/93 | (62,4) | 63/104 | (60,6) | NS |
dyspnea | 19/98 | (19,4) | 16/91 | (17,6) | NS |
respiratory distress | 3/96 | (3,1) | 0/96 | (0,0) | NS |
hepatomegaly | 36/107 | (33,6) | 28/95 | (29,5) | NS |
splenomegaly | 28/106 | (26,4) | 12/93 | (12,9) | 0,017 |
BIOLOGY
| |||||
anaemiad | 125/132 | (94,7) | 114/124 | (91,9) | NS |
severe anaemiae | 55/132 | (41,7) | 39/124 | (31,5) | NS |
hypoglycaemiaf | 30/132 | (22,7) | 21/124 | (16,9) | NS |
thrombopaeniag | 93/132 | (70,5) | 43/124 | (34,7) | <0,001 |
Severe malaria attacks
prevalence | case fatality rate | Odd Ratio | p value | |||
---|---|---|---|---|---|---|
number n = 114 | % | number/total | % | 95 % IC | ||
comaa | 22 | (19.3) | 12/21 | (57.1) | 9.33 (2.85 – 31.58) | < 0.001 |
impaired consciousnessb | 15 | (13.2) | 1/14 | (7.1) | 0.26 (0.01 – 2.07) | NS |
convulsionsc | 71 | (62.3) | 18/71 | (25.3) | 4.42 (0.88 – 29.83) | 0.04 |
respiratory distress | 3 | (2.6) | 3/3 | 0.002 | ||
severe anaemiad | 55 | (48.2) | 11/50 | (22.0) | 1.10 (0.40 – 3.05) | NS |
hypoglycaemiae | 30 | (26.3) | 11/28 | (39.3) | 3.72 (1.26 – 11.05) | 0.006 |
high parasitaemiaf | 39 | (34.2) | 7/37 | (18.9) | 0.82 (0.27 – 2.42) | NS |