Background
Methods
Search strategy
Inclusion criteria | Exclusion criteria |
---|---|
1. Diagnosis of PCOS accordance with to the NIH, Rotterdam or AES criteria. | 1. Studies that included women with preexisting diabetes mellitus or Hypertension. |
2. Use of women without PCOS as controls. | 2. Metformin was used by the PCOS group after conception. |
3. End points include GDM, PIH, PE, preterm, birth weight, caesarean section or admission to NICU. | 3. Multiple pregnancy rate was significantly different in the two groups. |
Eligibility of relevant studies
Data extraction
Study no. | Author | Year | Study design | Study center | Study size | No. of PCOS/control | Outcomes included | PCOS group | Control group | Multiple pregnancies | Notions |
---|---|---|---|---|---|---|---|---|---|---|---|
1
| Diamant [21] | 1982 | Retrospective | single center | 72 | 33/39 | PE, birthweight | Pregnant by ovulation induction | Anovulatory women pregnant by ovulation | Included,but equal Incidence | Matched for: age, similar parity |
2
| Levran [22] | 1990 | Retrospective | single center | 171 | 76/95 | GDM | Pregnant by CC,,hMG,or spontaneous | Normal pregnant Women | Not stated | Matched for age and BMI |
3
| Wortsman [23] | 1991 | Retrospective | multicenter | 2359 | 53/2,306 | GDM, birthweight | Pregnant by CC, hMG, dexamethasone, bromocriptine | Normal pregnant Women | Included,no significantly difference | Matched for age and BMI |
4
| Cardenas [24] | 1996 | Retrospective | single center | 109 | 77/31 | GDM, Birthweight | Pregnant by ovulation induction | Normal pregnant Women | Not included | matched for age and gravidity |
5
| Urman [25] | 1997 | Retrospective | single center | 147 | 47/100 | GDM,PIH, PE,preterm, NICU | Pregnant by CC,,hMG, dexamethasone,IVF | Normal pregnant Women | Not included | matched for age and gravidity, PCOS higher BMI |
6
| Lesser [26] | 1997 | Retrospective | single center | 68 | 24/44 | GDM | Pregnant by CC, hMG | infertility women pregnant by CC,hMG | Not stated | PCOS higher BMI |
7
| Fridstrom [27] | 1999 | Retrospective | single center | 99 | 33/66 | GDM,PIH,PE,birthweight, Cesarean section,NICU | Pregnant by IVF, ovulation Induction | Normal pregnant women | Included,,no significantly difference | matched for age and treatment |
8
| Radon [28] | 1999 | Retrospective | single center | 88 | 22/66 | GDM,PE, Birthweight | Pregnant by CC, hMG, IVF,or spontaneous | Normal pregnant Women | Not included | Matched for age and BMI |
9
| Kashyap [29] | 2000 | Retrospective | single center | 49 | 22/27 | PIH | Pregnant by hMG, ovulation Induction | Pregnant by hMG, IVF/IUI | Not stated | Similar BMI, age, parity |
10
| Vollenhoven [30] | 2000 | Retrospective | single center | 132 | 60/72 | GDM,PIH, preterm, birthweight, Cesarean section | Pregnant by ovulation induction | Normal pregnant Women | Included,no significantly difference | matched for age, BMI |
11
| Mikola [31] | 2001 | Retrospectiv | multicenter | 836 | 80/728 | GDM,PE, preterm, birthweight, Cesarean section | Pregnant by CC, gonadotrophins ,IVF | Normal pregnant Women | only singleton result included | PCOS higher BMI |
12
| Bjercke [11] | 2002 | Prospective | single center | 407 | 52/355 | GDM,PIH,PE,preterm, birthweight, Cesarean section, NICU | Pregnant by CC, hMG, IVF, IUI | Pregnant by ART | Not included | PCOS higher BMI |
13
| Haakova [32] | 2003 | Retrospective | Multicenter | 132 | 66/66 | GDM,PIH, preterm, birthweight, Cesarean section | Pregnant by ovulation Induction | Normal pregnant Women | Included,no significantly difference | Matched for age and BMI |
14
| Turhan [33] | 2003 | Retrospective | single center | 174 | 38/136 | GDM,PIH,PE,preterm, birthweight, Cesarean section,NICU | Not stated | Normal pregnant Women | Not included | matched for age |
15
| Weerakiet [34] | 2004 | Retrospective | single center | 311 | 47/264 | GDM,PIH,PE, preterm, birthweight, Cesarean section | Pregnant by CC, IVF, ovarian drilling | Normal pregnant Women | Not included | PCOS higher BMI |
16
| Sir-Petermann [35] | 2005 | Prospective | single center | 227 | 47/180 | GDM,PE, preterm, birthweight, NICU | Not stated | Normal pregnant Women | Not included | matched for age,BMI |
17
| Al-Ojaimi [36] | 2006 | Prospectiv | single center | 513 | 134/479 | GDM,PIH,PE, preterm, birthweight | treated with laparoscopic ovarian drilling | Normal pregnant Women | Not included | PCOS higher BMI |
18
| Hu [37] | 2007 | Prospective | single center | 44 | 22/22 | PIH, Birthweight | Spontaneous | Normal pregnant Women | Not included | matched for age,BMI, parity |
19
| Sir-Petermann [38] | 2007 | Prospective | single center | 99 | 48/51 | GDM,PIH | Not stated | Normal pregnant Women | Not stated | matched for age |
20
| Maliqueo [39] | 2009 | Prospective | single center | 64 | 30/34 | Birthweight | Spontaneous | Normal pregnant Women | Not included | PCOS higher BMI |
21
| Palomba [14] | 2010 | Prospective | single center | 162 | 93/69 | GDM,PIH,PE, preterm, Cesarean section | Spontaneous | Normal pregnant Women | Not included | matched for age, BMI and parity |
22
| Altieri [40] | 2010 | Retrospective | single center | 174 | 15/159 | GDM,PIH,PE, preterm, birthweight, Cesarean section | Spontaneous, ovulation induction, ART | Normal pregnant Women | Not included | matched for age, BMI and parity |
23
| Li [41] | 2010 | Prospective | single center | 104 | 34/70 | PE,preterm, birthweight | Pregnant by ART, Spontaneous | Normal pregnant Women | Not included | PCOS higher BMI |
24
| Roos [42] | 2011 | Prospective | single center | 1195123 | 3787/ 1 191 336 | GDM,PE ,preterm, Cesarean section | Pregnant by ART | Normal pregnant Women | Not included | PCOS higher BMI |
25
| Dmitrovic [43] | 2011 | Prospective | single center | 34 | 17/17 | GDM, Birthweight | Not stated | Not stated | Not included | results adjust for BMI |
26
| Han [44] | 2011 | Retrospective | Not stated | 1339 | 336/1003 | PIH,preterm | Pregnant by ovulation induction, ART | pregnant by ovulation induction, ART | Included,no significantly difference | matched by age, PCOS higher BMI |
27
| Reyes-Munoz [45] | 2012 | Retrospective | single center | 104 | 52/52 | GDM,PE, preterm, birthweight | Achieved pregnancy after OCs,CC | Normal pregnant Women | Not included | matched by age, parity, BMI |