Background
Results and Discussion
Patient # | Sampling: pre, post dose# | Course/ Cycle of Sampling | Response | Biological Response | # of doses |
---|---|---|---|---|---|
p1 | pre, post 1 | c1c2 | SD 2C | NR | 3 |
p2 | pre, post 1, post 4 | c3c1 | SD 2C | NR | 8 |
p3 | pre, post 1, post 5 | c3c1 | PR 1C CR 3C | BR | 5 |
p4 | pre, post 1, post 4 | c2c1 | PR 1C SD 2C PD | BR | 7 |
p5 | pre, post 1, post 4 | c1c2 | SD 1C PD 2C | NR | 6 |
p6 | pre, post 1 | c1c2 | PR 2C PD 3C | BR | 4 |
p7 | pre, post 1 | c2c1 | SD 1C | NR | 4 |
p8 | pre | c1c1 | PD 1C | NR | 8 |
p9 | pre, post 1, post 4 | c1c1 | PD 1C | NR | 7 |
p10 | pre, post 1 | c1c2 | MR 1C | BR | 7 |
p11 | pre, post 1 | c3c2 | SD 1C PR 3C | NR | 3 |
p12 | pre, post 1, post 4 | c1c1 | SD | NR | 8 |
p13 | pre, post 1, post 4 | c1c1 | PD 1C | NR | 7 |
p14 | pre, post 1, post 4 | c2c1 | MR 1C | BR | 8 |
p15 | pre, post 1, post 4 | c1c1 | MR 1C | BR | 7 |
p16 | pre, post 1, post 4 | c1c1 | PD | NR | 9 |
Patient # | Age yr | Doses | Hemoglobin | WBC count | Platelet Count | Bilirubin | SGOT | Creatinine |
---|---|---|---|---|---|---|---|---|
p1 | 41 | 3 | grade 2 | * | * | * | * | * |
p2 | 56 | 8 | * | * | grade 1 | * | * | * |
p3 | 53 | 5 | grade 1 | * | * | * | * | * |
p4 | 54 | 7 | * | * | grade 1 | grade 1 | grade 1 | grade 1 |
p5 | 58 | 6 | grade 2 | grade 2 | grade 2 | grade 3 | grade 1 | grade 3 |
p6 | 47 | 4 | grade 1 | * | * | * | * | * |
p7 | 54 | 4 | * | * | * | * | * | grade 2 |
p8 | 41 | 8 | grade 1 | * | * | grade 2 | grade 1 | * |
p9 | 44 | 7 | * | * | * | * | grade 1 | * |
p10 | 36 | 7 | * | * | * | * | * | * |
p11 | 60 | 3 | * | * | * | * | * | * |
p12 | 45 | 8 | * | * | grade 1 | * | grade 1 | grade 2 |
p13 | 70 | 7 | * | * | * | grade 1 | grade 1 | * |
p14 | 36 | 8 | * | grade 1 | grade 3 | * | * | * |
p15 | 66 | 7 | * | * | * | * | grade 3 | * |
p16 | 56 | 9 | * | * | * | * | grade 2 | * |
Soluble Factor | Average before IL-2 | STD error before | Average after 1 dose | STD error after 1 dose | p value before vs. after I dose | Bonferroni correction |
---|---|---|---|---|---|---|
IL2*
| 0 | 0 | 3269 | 841 | 0.00126 | 0.07409 |
TNFR2
| 3197 | 222 | 6215 | 462 | 0.00000 | 0.00001 |
MMP9
| 246408 | 29501 | 764715 | 53413 | 0.00000 | 0.00008 |
TNFR1
| 1659 | 92 | 5217 | 568 | 0.00000 | 0.00024 |
IFNγ
| 152 | 17 | 235 | 19 | 0.00000 | 0.00027 |
IP10
| 152 | 13 | 2006 | 267 | 0.00001 | 0.00030 |
MIP3b
| 151 | 12 | 421 | 45 | 0.00001 | 0.00040 |
MCP2
| 36 | 6 | 1776 | 261 | 0.00001 | 0.00045 |
MIP1b
| 525 | 137 | 35905 | 5761 | 0.00002 | 0.00100 |
MMP8
| 1502 | 321 | 3977 | 537 | 0.00002 | 0.00109 |
SDF1b
| 75 | 16 | 836 | 137 | 0.00005 | 0.00322 |
Lymph
| 142 | 20 | 338 | 43 | 0.00007 | 0.00407 |
IL7
| 3 | 1 | 10 | 2 | 0.00008 | 0.00477 |
IL5
| 1 | 1 | 9 | 2 | 0.00012 | 0.00691 |
MCP3
| 12 | 1 | 23 | 3 | 0.00020 | 0.01172 |
I309
| 22 | 4 | 73 | 12 | 0.00026 | 0.01547 |
E-Selectin
| 111526 | 5901 | 127683 | 5461 | 0.00030 | 0.01753 |
IL15
| 1 | 1 | 6 | 1 | 0.00038 | 0.02261 |
Eotaxin
| 130 | 16 | 401 | 65 | 0.00047 | 0.02757 |
ITAC
| 31 | 3 | 139 | 25 | 0.00056 | 0.03314 |
MIP1a
| 3000 | 111 | 3228 | 104 | 0.00102 | 0.06033 |
Gro-A
| 297 | 95 | 1848 | 388 | 0.00104 | 0.06121 |
Angio2
| 467 | 58 | 671 | 71 | 0.00107 | 0.06330 |
IL6
| 61 | 13 | 1092 | 265 | 0.00112 | 0.06589 |
VegF
| 1112 | 139 | 1498 | 132 | 0.00130 | 0.07661 |
MCP1
| 1327 | 248 | 124449 | 32058 | 0.00136 | 0.08025 |
MIG
| 262 | 35 | 933 | 178 | 0.00262 | 0.15480 |
IL8
| 65 | 4 | 800 | 211 | 0.00278 | 0.16379 |
IL4
| 0 | 0 | 4 | 1 | 0.00422 | 0.24896 |
TNFa
| 539 | 48 | 640 | 50 | 0.00719 | 0.42432 |
TARC
| 282 | 47 | 520 | 88 | 0.00939 | 0.55398 |
MIP3a
| 17 | 3 | 827 | 291 | 0.01195 | 0.70484 |
IL6R
| 24605 | 1759 | 27935 | 2652 | 0.01393 | 0.82204 |
IL10
| 2 | 1 | 41 | 15 | 0.01517 | 0.89505 |
MDC
| 605 | 77 | 661 | 74 | 0.03338 | 1.96915 |
MMP10
| 1440 | 148 | 1645 | 147 | 0.04876 | 2.87674 |
MMP1
| 13937 | 1775 | 16437 | 1602 | 0.05007 | 2.95398 |
Soluble Factor | Average before IL-2 | STD error before IL-2 | Average after 1 dose | STD error after 1 dose | p value before vs. after 1 dose | Bonferroni Correction |
---|---|---|---|---|---|---|
IL2*
| 0 | 0 | 3668 | 1178 | 0.00948 | 0.55953 |
TNFR1
| 1641 | 112 | 4702 | 512 | 0.00005 | 0.00292 |
MMP8
| 1187 | 455 | 3340 | 500 | 0.00008 | 0.00486 |
TNFR2
| 3195 | 259 | 6014 | 628 | 0.00010 | 0.00588 |
MCP1
| 984 | 227 | 81270 | 13486 | 0.00013 | 0.00787 |
IP10
| 146 | 18 | 1571 | 273 | 0.00047 | 0.02778 |
MCP2
| 32 | 9 | 1500 | 291 | 0.00050 | 0.02950 |
MMP9
| 233004 | 43617 | 736428 | 76301 | 0.00051 | 0.02984 |
I309
| 18 | 4 | 52 | 8 | 0.00057 | 0.03372 |
IFNγ
| 149 | 21 | 222 | 25 | 0.00059 | 0.03477 |
IL5
| 0 | 0 | 8 | 2 | 0.00094 | 0.05563 |
MIP1b
| 512 | 205 | 30149 | 6560 | 0.00097 | 0.05714 |
MIP3b
| 142 | 17 | 347 | 51 | 0.00108 | 0.06345 |
VegF
| 865 | 131 | 1392 | 181 | 0.00175 | 0.10307 |
IL7
| 2 | 1 | 10 | 2 | 0.00228 | 0.13444 |
IL15
| 0 | 0 | 6 | 2 | 0.00302 | 0.17834 |
E-Selectin
| 106029 | 5703 | 118981 | 5972 | 0.00351 | 0.20688 |
SDF1b
| 62 | 21 | 646 | 154 | 0.00372 | 0.21974 |
Lymph
| 111 | 22 | 259 | 39 | 0.00400 | 0.23580 |
IL6
| 50 | 5 | 747 | 201 | 0.00521 | 0.30754 |
MCP3
| 10 | 1 | 17 | 2 | 0.00616 | 0.36333 |
MMP1
| 12912 | 2478 | 17411 | 2235 | 0.00686 | 0.40490 |
Eotaxin
| 115 | 22 | 318 | 65 | 0.00762 | 0.44948 |
MIP1a
| 2952 | 143 | 3215 | 141 | 0.00790 | 0.46638 |
Angio2
| 494 | 78 | 655 | 101 | 0.01068 | 0.63039 |
MCP4
| 84 | 19 | 264 | 71 | 0.01082 | 0.63834 |
ITAC
| 29 | 4 | 110 | 26 | 0.01104 | 0.65159 |
TARC
| 248 | 59 | 478 | 112 | 0.02152 | 1.26942 |
IL8
| 61 | 4 | 456 | 151 | 0.02259 | 1.33290 |
IL4
| 0 | 0 | 5 | 2 | 0.02601 | 1.53464 |
TNFa
| 521 | 65 | 610 | 59 | 0.02824 | 1.66587 |
Gro-A
| 314 | 146 | 1401 | 468 | 0.03637 | 2.14567 |
TIMP2
| 75277 | 5629 | 85674 | 4973 | 0.04508 | 2.65947 |
KGF
| 373 | 117 | 470 | 97 | 0.04513 | 2.66289 |
Soluble Factor | Average before IL-2 | STD error before IL-2 | Average after 4 doses | STD error after 4 doses | p value before vs. after 4 doses | Bonferroni correction |
---|---|---|---|---|---|---|
IL2*
| 0 | 0 | 1426 | 394 | 0.00410 | 0.24205 |
MCP2
| 32 | 9 | 296 | 34 | 0.00001 | 0.00047 |
I309
| 18 | 4 | 222 | 25 | 0.00001 | 0.00070 |
IP10
| 146 | 18 | 2940 | 390 | 0.00003 | 0.00178 |
VegF
| 865 | 131 | 1411 | 132 | 0.00003 | 0.00191 |
ITAC
| 29 | 4 | 438 | 57 | 0.00003 | 0.00200 |
TNFR1
| 1641 | 112 | 6067 | 651 | 0.00004 | 0.00207 |
IFNγ
| 149 | 21 | 246 | 16 | 0.00004 | 0.00234 |
IL15
| 0 | 0 | 14 | 2 | 0.00005 | 0.00269 |
MCP1
| 984 | 227 | 31267 | 4583 | 0.00006 | 0.00367 |
MIP3b
| 142 | 17 | 33836 | 5140 | 0.00007 | 0.00405 |
Lymph
| 111 | 22 | 639 | 95 | 0.00010 | 0.00571 |
E-Selectin
| 106029 | 5703 | 377934 | 40503 | 0.00011 | 0.00638 |
TARC
| 248 | 59 | 8993 | 1517 | 0.00015 | 0.00867 |
SDF1b
| 62 | 21 | 883 | 142 | 0.00018 | 0.01045 |
MMP8
| 1187 | 455 | 5081 | 927 | 0.00024 | 0.01406 |
MCP3
| 10 | 1 | 53 | 8 | 0.00029 | 0.01685 |
MDC
| 586 | 111 | 1272 | 214 | 0.00031 | 0.01841 |
Eotaxin
| 115 | 22 | 392 | 67 | 0.00032 | 0.01890 |
TIMP2
| 75277 | 5629 | 108359 | 4266 | 0.00033 | 0.01949 |
Exodus2
| 419 | 71 | 1108 | 157 | 0.00049 | 0.02911 |
MMP13
| 839 | 221 | 1742 | 171 | 0.00055 | 0.03224 |
TIMP1
| 198383 | 20136 | 1021646 | 178036 | 0.00071 | 0.04194 |
TNFa
| 521 | 65 | 839 | 74 | 0.00086 | 0.05090 |
MIP1b
| 512 | 205 | 4072 | 794 | 0.00105 | 0.06189 |
TNFR2
| 3195 | 259 | 16353 | 3113 | 0.00115 | 0.06774 |
HGF
| 8281 | 2359 | 17298 | 1311 | 0.00251 | 0.14822 |
IL5
| 0 | 0 | 40 | 10 | 0.00274 | 0.16167 |
MMP9
| 233004 | 43617 | 657077 | 142793 | 0.00391 | 0.23066 |
IL7
| 2 | 1 | 6 | 2 | 0.00508 | 0.29968 |
MMP2
| 210099 | 37913 | 399516 | 50101 | 0.00510 | 0.30111 |
MMP10
| 1467 | 220 | 3247 | 528 | 0.00545 | 0.32168 |
MCP4
| 84 | 19 | 1663 | 495 | 0.00698 | 0.41181 |
IL10
| 3 | 1 | 179 | 54 | 0.00707 | 0.41723 |
MIP3a
| 18 | 4 | 1346 | 414 | 0.00784 | 0.46274 |
IL6
| 50 | 5 | 608 | 184 | 0.01139 | 0.67211 |
VCAM1
| 310701 | 30008 | 1278753 | 336280 | 0.01248 | 0.73618 |
MMP3
| 27613 | 6960 | 59390 | 16227 | 0.01433 | 0.84561 |
KGF
| 373 | 117 | 505 | 109 | 0.01473 | 0.86914 |
ICAM1
| 499363 | 62669 | 2313052 | 682964 | 0.01505 | 0.88787 |
IL6R
| 23556 | 1882 | 19437 | 1316 | 0.02143 | 1.26450 |
IL4
| 0 | 0 | 5 | 2 | 0.02359 | 1.39181 |
IL8
| 61 | 4 | 296 | 90 | 0.02410 | 1.42202 |
IL18
| 67 | 11 | 167 | 43 | 0.03041 | 1.79442 |
IL16
| 13 | 6 | 104 | 43 | 0.04344 | 2.56278 |
MIP1a
| 2952 | 143 | 3160 | 156 | 0.05446 | 3.21343 |
Soluble Factor | Average before IL-2 | STD error before Il-2 | Average after 1 dose | STD error after 1 dose | Average after 4 doses | STD error after 4 doses | pvalue after 1 vs after 4 doses | Bonferroni correction |
---|---|---|---|---|---|---|---|---|
I309
| 18 | 4 | 52 | 8 | 222 | 25 | 0.00004 | 0.00232 |
MIP3b
| 18 | 4 | 347 | 51 | 33836 | 5140 | 0.00007 | 0.00414 |
TARC
| 248 | 59 | 478 | 112 | 8993 | 1517 | 0.00015 | 0.00882 |
E-Selectin
| 106029 | 5703 | 118981 | 5972 | 377934 | 40503 | 0.00018 | 0.01034 |
Exodus2
| 419 | 71 | 307 | 26 | 1108 | 157 | 0.00028 | 0.01628 |
MDC
| 586 | 111 | 644 | 109 | 1272 | 214 | 0.00029 | 0.01740 |
ITAC
| 29 | 4 | 110 | 26 | 438 | 57 | 0.00033 | 0.01935 |
Lymph
| 111 | 22 | 259 | 39 | 639 | 95 | 0.00083 | 0.04905 |
MCP3
| 10 | 1 | 17 | 2 | 53 | 8 | 0.00101 | 0.05956 |
TIMP1
| 198383 | 20136 | 242215 | 25530 | 1021646 | 178036 | 0.00116 | 0.06856 |
HGF
| 8281 | 2359 | 10836 | 1791 | 17298 | 1311 | 0.00148 | 0.08712 |
IL15
| 0 | 0 | 6 | 2 | 14 | 2 | 0.00148 | 0.08719 |
MMP13
| 839 | 221 | 1081 | 251 | 1742 | 171 | 0.00163 | 0.09604 |
MCP2
| 32 | 9 | 1500 | 291 | 296 | 34 | 0.00174 | 0.10287 |
MIP1b
| 512 | 205 | 30149 | 6560 | 4072 | 794 | 0.00180 | 0.10631 |
TNFR2
| 3195 | 259 | 6014 | 628 | 16353 | 3113 | 0.00221 | 0.13028 |
TNFa
| 521 | 65 | 610 | 59 | 839 | 74 | 0.00281 | 0.16587 |
MCP1
| 984 | 227 | 81270 | 13486 | 31267 | 4583 | 0.00447 | 0.26392 |
NAP2
| 9479881 | 2329514 | 10970212 | 2240959 | 8251596 | 2122243 | 0.00482 | 0.28444 |
IL5
| 0 | 0 | 8 | 2 | 40 | 10 | 0.00564 | 0.33291 |
MMP8
| 1187 | 455 | 3340 | 500 | 5081 | 927 | 0.00852 | 0.50244 |
MMP2
| 210099 | 37913 | 201099 | 41748 | 399516 | 50101 | 0.00889 | 0.52449 |
MCP4
| 84 | 19 | 264 | 71 | 1663 | 495 | 0.00932 | 0.54966 |
IL6R
| 23556 | 1882 | 26254 | 3045 | 19437 | 1316 | 0.01011 | 0.59636 |
ICAM1
| 499363 | 62669 | 501688 | 90740 | 2313052 | 682964 | 0.01143 | 0.67431 |
MMP3
| 27613 | 6960 | 24603 | 5418 | 59390 | 16227 | 0.01149 | 0.67778 |
MMP10
| 1467 | 220 | 1694 | 218 | 3247 | 528 | 0.01209 | 0.71314 |
TIMP2
| 75277 | 5629 | 85674 | 4973 | 108359 | 4266 | 0.01334 | 0.78706 |
VCAM1
| 310701 | 30008 | 335385 | 17713 | 1278753 | 336280 | 0.01469 | 0.86698 |
IP10
| 146 | 18 | 1571 | 273 | 2940 | 390 | 0.01571 | 0.92712 |
IL10
| 3 | 1 | 45 | 23 | 179 | 54 | 0.02652 | 1.56497 |
IL18
| 67 | 11 | 93 | 19 | 167 | 43 | 0.03116 | 1.83873 |
TNFR1
| 1641 | 112 | 4702 | 512 | 6067 | 651 | 0.03126 | 1.84407 |
IL16
| 13 | 6 | 19 | 11 | 104 | 43 | 0.04434 | 2.61591 |
Rantes
| 40861 | 10853 | 56208 | 8799 | 34797 | 6495 | 0.04881 | 2.87988 |