Background
Methods
Study design and search strategy
Study selection
Data extraction and risk of bias in individual studies
Statistical analysis
Results
Country, trial | n | Definition of MetS | Age years | Gender | Type of intervention | Duration, years | Rate, % = number free from MetS/number subjects) | Mean difference (SE) | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Intervention | Control | FBG | Waist | SBP | DBP | TG | HDL | |||||||
UK, CARMEN trial [23] | 46 | 3+ risk factors | 46 | M/F | LF-SC | 0.5 | - | - | - | 0.0 (2.02) | -13.0 (5.56) | -0.6 (4.29) | 50.7 (19.95) | 0.5 (2.42) |
UK, CARMEN trial [23] | 46 | ≥3 MetS risk factors | 46 | M/F | LF-CC | 0.5 | - | - | - | -4.0 (2.94) | -15.0 (6.33) | -4.2 (4.29) | 0.0 (16.62) | -1.5 (2.42) |
USA [22] | 53 | Syndrome X | >29 | M/F | EX+WL | 0.5 | - | - | -8.0 (4.84) | - | -6.0 (4.17) | -9.0 (2.08) | -17.0 (64.11) | 4.0 (4.26) |
Italy [21]b
| 164 | ATP III | 44 | M/F | Med diet | 2 | 20% = 18/90 | 67% = 60/90 | -6.0 (0.35) | -2.0 (0.05) | -3.0 (0.24) | --2.0 (0.15) | -19.0 (0.90) | 3.0 (0.24) |
Tehran Lipid and Glucose Study [20]b
| 116 | ATP III | 41 | M/F | WR | 0.5 | 0% = 0/40 | 18% = 7/38 | -6.0 (5.18) | 0.0 (4.31) | -3.0 (5.58) | -1.0 (3.01) | -15.0 (11.34) | -6.0 (2.22) |
Tehran Lipid and Glucose Study [20]b
| 116 | ATP III | 41 | M/F | DASH | 0.5 | 0% = 0/40 | 34% = 13/38 | 3.0 (5.83) | -5.0 (4.48) | -11.0 (3.80) | -6.0 (2.96) | -17.0 (11.34) | 1.0 (2.16) |
Part of DPPRG Study [19] | 1711 | ATP III | 25-82 M/F | M/F | L | 3 | 18% = 107/592 | 38% = 209/549 | - | - | - | - | - | - |
Italy [18]b
| 335 | ATP III or hs-CRP+2 | 56 | M/F | L | 1 | 34% = 41/120c
| 65% = 77/119c
| -5.9 (1.28) | -4.6 (0.64) | -6.8 (1.92) | -2.3 (1.03) | -16.0 (8.95) | 3.6 (5.84) |
Part of PREDIMED study [17] | 499 | Med diet | 67 | M/F | Med diet+nuts | 3 | 16% = 41/250 | 25% = 63/249 | - | - | - | - | - | - |
Part of PREDIMED study [17] | 502 | Med diet | 67 | M/F | Med diet+V00 | 3 | 16% = 41/250 | 21% = 53/252 | - | - | - | - | - | - |
Part of Finnish DPS study [16] | 502 | ATPIII high risk | 55 | M/F | L | 1 | 15% = 26/177 | 27% = 49/184 | - | - | - | - | - | - |
Types of intervention
Dietary intervention
Diet and lifestyle modification
Risk of bias
Relative proportion of patients with resolved MetS
Total (95% CI) | Model | Point Estimate d
| 95% CI (lowerto upper) |
---|---|---|---|
The ratio of proportions patients with resolved MetS (7 interventions)a
| Random | 2.0 | 1.5 to 2.7 |
Bayesian | 2.4 | 1.5 to 5.5 | |
Fixed | 1.9 | 1.7 to 2.2 | |
Mean difference (7 interventions) b
| |||
Fasting blood glucose, mg/dl | Random c
| -11.5 | -22.4 to -0.6 |
(5 interventions) | Bayesian | -5.1 | -8.6 to -0.9 |
Fixed | -18.7 | -20.4 to -17.0 | |
Waist circumference, cm (6 interventions) | Random c
| -2.7 | -4.6 to -0.9 |
Bayesian | -2.6 | -4.6 to -0.6 | |
Fixed | -2.0 | -2.1 to -1.9 | |
SBP, mmHg | Random c
| -6.4 | -9.7 to -3.2 |
Bayesian | -7.9 | -12.3 to -3.9 | |
Fixed | -3.1 | -3.6 to -2.7 | |
DBP, mmHg | Random c
| -3.3 | -5.2 to -1.4 |
Bayesian | -3.5 | -6.2 to -0.97 | |
Fixed | -2.0 | -2.3 to -1.8 | |
Triglyceride, mg/dl | Random c
| -12.0 | -22.2 to -1.7 |
Bayesian | -4.8 | -28.1 to 18.8 | |
Fixed | -18.7 | -20.4 to -17.0 | |
HDL, mg/dl | Random c
| 1.3 | -0.6 to 3.1 |
Bayesian | 0.7 | -2.4 to 3.8 | |
Fixed | 2.9 | 2.5 to 3.3 |