Background
Results
Young | Elderly | Group A vs. B | |||||
---|---|---|---|---|---|---|---|
Control n=36 | Septic shock (group A) n=21 | p-value | Control n=8 | Septic shock (group B) n=8 | p-value | p-value | |
age (yrs)
| 45 ± 11 | 40 ± 13 | 0.154 | 73 ± 6 | 75 ± 9 | 0.666 | 0.000 |
male sex
| 38% | 50 | 0.454 | 50 | 62% | 0.766 | |
creatinin (mg/dl)
| 1.50 ± 2.73 | 1.04 ± 1.24 | 0.523 | 1.50 ± 1.60 | 2.62 ± 1.40 | 0.173 | 0.017 |
sodium (meq/dl)
| 142 ± 11 | 139 ± 9 | 0.133 | 141 ± 6 | 146 ± 18 | 0.454 | 0.283 |
potassium (meq/dl)
| 3.52 ± 0.84 | 3.52 ± 1.16 | 0.988 | 3.62 ± 0.74 | 4.25 ± 0.70 | 0.122 | 0.055 |
magnesium (mg/dl)
| 1.44 ± 0.55 | 1.19 ± 0.51 | 0.147 | 1.38 ± 0.51 | 1.63 ± 0.51 | 0.302 | 0.064 |
calcium (mg/dl)
| 4.77 ± 0.86 | 4.42 ± 0.74 | 0.100 | 4.75 ± 0.46 | 4.12 ± 0.64 | 0.043 | 0.294 |
phosphate (mg/dl)
| 3.03 ± 1.15 | 3.86 ± 2.47 | 0.073 | 3.75 ± 1.66 | 4.38 ± 1.92 | 0.482 | 0.577 |
chloride (mg/dl)
| 107 ± 12 | 105 ± 7 | 0.527 | 108 ± 10 | 104 ± 6 | 0.394 | 0.703 |
hemoglobin (g/dl)
| 12 ± 2.0 | 10 ± 2.2 | 0.011 | 10 ± 2.0 | 10 ± 2.2 | 0.913 | 0.939 |
hematocrit (g/dl)
| 36 ± 6 | 30 ± 6 | 0.010 | 31 ± 6 | 32 ± 6 | 1.000 | 0.769 |
leucocytes (/mm3)
| 10891 ± 4386 | 15569 ± 13341 | 0.046 | 17830 ± 23033 | 11863 ± 6020 | 0.499 | 0.314 |
PMN cells (/mm3)
| 8778 ± 4003 | 12406 ± 10710 | 0.061 | 7518 ± 3917 | 10446 ± 5632 | 0.231 | 0.529 |
platelets (/mm3)
| 235833 ± 136039 | 224571 ± 171250 | 0.769 | 196500 ± 86663 | 152750 ± 69134 | 0.267 | 0.119 |
albumin (g/dl)
| 2.83 ± 0.81 | 2.04 ± 0.74 | 0.000 | 2.62 ± 0.51 | 2.12 ± 0.35 | 0.039 | 0.708 |
lactate (g/dl)
| 12.75 ± 6.83 | 31.61 ± 35.91 | 0.001 | 11.25 ± 4.71 | 19.12 ± 9.32 | 0.311 | 0.154 |
CRP (g/dl)
| 50 ± 76 | 139 ± 129 | 0.003 | 56 ± 73 | 96 ± 162 | 0.494 | 0.939 |
SOFA score
| 3.50 ± 3.12 | 9.14 ± 4.13 | 0.000 | 4.13 ± 3.22 | 9.25 ± 2.96 | 0.002 | 0.517 |
ICU mortality
| 11% | 47% | 0.003 | 37.5% | 50% | 0.628 | 0.939 |
Young | Elderly | Group A vs. B | |||||
---|---|---|---|---|---|---|---|
Control n=36 | Septic shock (group A) n=21 | p-value | Control n=8 | Septic shock (group B) n=8 | p-value | p-value | |
IL-1α
| 31 ± 42 | 100 ± 82 | 0.000 | 27 ± 27 | 75 ± 82 | 0.270 | 0.242 |
IL-1β
| 2.50 ± 2.93 | 7.09 ± 7.11 | 0.007 | 1.12 ± 1.35 | 4.37 ± 6.98 | 0.480 | 0.148 |
IL-1 RA
| 36 ± 47 | 192 ± 295 | 0.001 | 31 ± 33 | 145 ± 292 | 0.114 | 0.317 |
IL-2
| 9.00 ± 6.74 | 13 ± 10 | 0.121 | 4.12 ± 2.10 | 9.62 ± 5.52 | 0.023 | 0.508 |
IL-3
| 2.08 ± 2.44 | 2.61 ± 3.33 | 0.849 | 0.62 ± 0.51 | 2.25 ± 2.54 | 0.070 | 0.899 |
IL-4
| 8.55 ± 10.60 | 32 ± 48 | 0.007 | 3.87 ± 4.91 | 16.00 ± 22.35 | 0.093 | 0.334 |
IL-5
| 2.19 ± 3.24 | 7.19 ± 9.26 | 0.010 | 0.50 ± 1.06 | 2.87 ± 3.44 | 0.082 | 0.208 |
IL-6
| 37 ± 63 | 1641 ± 3195 | 0.000 | 32 ± 39 | 1666 ± 3590 | 0.036 | 0.884 |
IL-7
| 11 ± 8.26 | 40 ± 39 | 0.000 | 5.62 ± 3.46 | 34.75 ± 48.70 | 0.002 | 0.393 |
IL-8
| 29 ± 25 | 806 ± 2819 | 0.000 | 26.25 ± 22.24 | 1695 ± 4602 | 0.016 | 0.354 |
IL-9
| 2.08 ± 2.37 | 4.52 ± 5.06 | 0.044 | 0.50 ± 1.06 | 4.25 ± 6.11 | 0.043 | 0.489 |
IL-10
| 12 ± 16 | 626 ± 2195 | 0.000 | 38 ± 78 | 480 ± 1079 | 0.012 | 0.575 |
IL-12p40
| 39 ± 44 | 111 ± 80 | 0.000 | 31 ± 34 | 141 ± 214 | 0.206 | 0.464 |
IL-12p70
| 7.19 ± 4.79 | 20.61 ± 20.09 | 0.002 | 4.50 ± 2.72 | 10.50 ± 8.79 | 0.423 | 0.195 |
IL-13
| 4.86 ± 6.51 | 14.90 ± 32.48 | 0.119 | 1.37 ± 1.06 | 10.87 ± 16.12 | 0.097 | 0.583 |
IL-15
| 7.38 ± 6.23 | 20.52 ± 25.30 | 0.001 | 4.00 ± 3.20 | 16.62 ± 18.92 | 0.011 | 0.558 |
IL-17
| 2.88 ± 2.43 | 8.66 ± 6.31 | 0.000 | 1.87 ± 1.45 | 6.87 ± 5.46 | 0.018 | 0.493 |
IFNα
| 67 ± 42 | 110 ± 58 | 0.000 | 195 ± 402 | 78 ± 38 | 0.270 | 0.150 |
IFNy
| 7.83 ± 4.45 | 40.09 ± 52.41 | 0.000 | 6.25 ± 5.67 | 30.87 ± 36.56 | 0.013 | 0.574 |
TFNα
| 19 ± 21 | 111 ± 207 | 0.000 | 23 ± 20 | 81 ± 102 | 0.016 | 0.770 |
Young | Elderly | Group A vs. B | |||||
---|---|---|---|---|---|---|---|
Control n=36 | Septic shock (group A) n=21 | p-value | Control n=8 | Septic shock (group B) n=8 | p-value | p-value | |
EGF
| 266 ± 212 | 212 ± 182 | 0.264 | 192 ± 80 | 250 ± 213 | 0.600 | 0.696 |
FGF2
| 122 ± 62 | 133 ± 55 | 0.301 | 113 ± 45 | 153 ± 67 | 0.344 | 0.575 |
FITL3
| 6.27 ± 11.4 | 18 ± 165 | 0.000 | 6.25 ± 14.04 | 16 ± 27 | 0.235 | 0.104 |
FRAKTALINE
| 167 ± 81 | 573 ± 858 | 0.001 | 120 ± 73 | 296 ± 273 | 0.027 | 0.251 |
GCSF
| 156 ± 196 | 3662 ± 7100 | 0.001 | 104 ± 106 | 3226 ± 7166 | 0.093 | 0.922 |
GMCSF
| 32 ± 21 | 125 ± 284 | 0.000 | 48 ± 65 | 54 ± 43 | 0.208 | 0.241 |
GRO
| 1958 ± 1642 | 2644 ± 3934 | 0.772 | 1733 ± 884 | 4074 ± 4718 | 0.753 | 0.435 |
MCP-1
| 610 ± 912 | 2806 ± 4334 | 0.002 | 916 ± 1129 | 3237 ± 4792 | 0.171 | 1.0 |
MCP-3
| 24 ± 13 | 58 ± 44 | 0.001 | 11.62 ± 5.20 | 32 ± 25 | 0.023 | 0.130 |
MDC
| 817 ± 719 | 714 ± 471 | 0.869 | 745 ± 350 | 625 ± 265 | 0.208 | 0.527 |
MIP-1
| 23 ± 22 | 50 ± 65 | 0.069 | 322 ± 871 | 39 ± 25 | 0.127 | 0.696 |
MIP-1
| 42 ± 25 | 102 ± 83 | 0.000 | 35 ± 31 | 94 ± 60 | 0.027 | 0.678 |
VEGF
| 227 ± 306 | 310 ± 239 | 0.003 | 143 ± 115 | 392 ± 387 | 0.021 | 0.678 |