Background
Results and Discussion
Results
Circulating IL-18 levels as a specific biomarker to distinguish MetS patients from subjects with pre-MetS conditions
Characteristics | MetS (n = 28) | Pre-MetS (n = 14) | Control (n = 14) |
---|---|---|---|
Age (year) | 54.8 ± 12.9 | 58.9 ± 13.0 | 56.4 ± 10.1 |
Sex, female (%) | 9 (32.1%) | 6 (42.9%) | 8 (57.1%) |
BMI (kg/m2) | 30.9 ± 7.7* | 27.6 ± 3.2 | 23.3 ± 2.9 |
Waist circumference (cm) | 102.7 ± 13.2*# | 95.0 ± 7.5* | 78.7 ± 7.2 |
Components | MetS | Pre-MetS | Control |
---|---|---|---|
Plasma glucose (mg/dL) | 136 ± 50* | 110 ± 12 | 99 ± 7 |
Plasma insulin (IU/mL) | 8.7 ± 5.6*# | 6.3 ± 2.7 | 5.2 ± 1.5 |
HOMA-IR | 2.0 ± 1.1* | 1.7 ± 0.7* | 1.3 ± 0.4 |
HDL cholesterol (mg/dL) | 48 ± 12* | 59 ± 16* | 71 ± 16 |
Triglyceride (mg/dL) | 187 ± 25* | 160 ± 24* | 69 ± 21 |
Hypertension, n (%) | 21 (75.0%)* | 5 (35.7%)# | 3 (21.4%) |
MetS | Pre-MetS | Control | |
---|---|---|---|
HbA1c (%) | 6.3 ± 1.3* | 5.4 ± 0.4 | 5.0 ± 0.3 |
CRP (μg/dL) | 365 ± 272* | 114 ± 98 | 82 ± 55 |
adiponectin (μg/mL) | 5.0 ± 0.7* | 5.5 ± 0.8* | 6.3 ± 0.9 |
IL-18 (pg/mL) | 301 ± 220*# | 121 ± 31 | 112 ± 29 |
Circulating IL-18 as a useful biomarker for lifestyle modification
Characteristics | Values | (range) |
---|---|---|
Age (year) | 55.4 ± 13.2 | 28-76 |
Sex, female (%) | 27 (54.0%) | |
Body mass index (kg/m2) | 31.9 ± 6.2 | 24-61 |
Body weight (kg) | 84.5 ± 18.6 | 54.5-138 |
Waist circumference (cm) | 104.5 ± 12.0 | 85.5-144 |
Systolic blood pressure (mmHg) | 138.7 ± 17.7 | |
Diastolic blood pressure (mmHg) | 78.3 ± 11.8 | |
Triglyceride (mg/dL) | 189.5 ± 121.3 | |
HDL-cholesterol (mg/dL) | 50.1 ± 11.5 | |
Plasma glucose (mg/dL) | 123.4 ± 37.0 | |
Hypertension (%) | 74 | |
High triglyceride (%) | 49 | |
Low HDL-cholesterol (%) | 11 | |
DM/IFG (%) | 61 |
Characteristics | Values | (range) |
---|---|---|
Δ Body mass index (kg/m2) | 1.6 ± 1.1# | (0.4-5.0) |
Δ Body weight (kg) | 5.4 ± 4.4# | (2.8-33.0) |
Δ Waist circumference (cm) | 9.6 ± 5.5* | (1.5-24.5) |
Δ Systolic blood pressure (mmHg) | 15.3 ± 17.5* | |
Δ Diastolic blood pressure (mmHg) | 12.1 ± 19.1# |
before | after | P values | |
---|---|---|---|
Triglyceride (mg/dL) | 190 ± 121 | 139 ± 67 | 0.049 |
HDL-cholesterol (mg/dL) | 50 ± 12 | 56 ± 11 | < 0.001 |
Glucose (mg/dL) | 123 ± 37 | 105 ± 19 | 0.041 |
Adiponectin (μg/mL) | 5.4 ± 1.5 | 6.5 ± 2.1 | 0.034 |
IL-18 (pg/mL) | 158 ± 97 | 119 ± 75 | 0.021 |
CRP (μg/dL) | 311 ± 315 | 204 ± 219 | 0.012 |