Background
Methods
Cervical cancer
Precancerous cervical lesions
Results
Cervical cancer
World | Africa | Asia | Western/ Central Asia | Eastern Asia | Latin America | South America | Central America | North America | Europe | Oceania | |
---|---|---|---|---|---|---|---|---|---|---|---|
(n = 8,977) | (n = 544) | (n = 2,641) | (n = 836) | (n = 1,805) | (n = 3,404) | (n = 2,629) | (n = 775) | (n = 160) | (n = 2,058) | (n = 170) | |
RC % (95%CI) | RC % (95%CI) | RC % (95%CI) | RC % (95%CI) | RC % (95%CI) | RC % (95%CI) | RC % (95%CI) | RC % (95%CI) | RC % (95%CI) | RC % (95%CI) | RC % (95%CI) | |
Combinations of HPV types
| |||||||||||
9 HPV types*
| 89.4 (88.8-90.1) | 86.9 (83.8-89.7) | 91.5 (90.4-92.5) | 92.0 (89.9-93.7) | 91.3 (89.9-92.6) | 88.2 (87.0-89.2) | 89.2 (87.9-90.3) | 84.6 (81.9-87.1) | 95.5 (91.2-98.2) | 89.1 (87.7-90.4) | 89.4 (83.8-93.6) |
16/18
| 70.8 (69.8-71.7) | 70.3 (66.2-74.0) | 71.6 (69.8-73.4) | 77.5 (74.5-80.3) | 68.9 (66.7-71.1) | 68.2 (66.6-69.8) | 69.4 (67.6-71.1) | 64.4 (60.9-67.8) | 78.8 (71.6-84.8) | 72.8 (70.8-74.7) | 78.2 (71.3-84.2) |
31/33/45/52/58
| 18.5 (17.7-19.3) | 16.7 (13.7-20.1) | 19.8 (18.3-21.3) | 14.5 (12.2-17.0) | 22.3 (20.4-24.3) | 19.8 (18.5-21.2) | 19.6 (18.1-21.2) | 20.3 (17.5-23.3) | 16.9 (11.4-23.6) | 16.2 (14.6-17.8) | 8.8 (5.0-14.1) |
Other Types
| 10.6 (9.9-11.2) | 13.0 (10.3-16.2) | 8.5 (7.5-9.6) | 8.0 (6.3-10.1) | 8.7 (7.4-10.1) | 11.8 (10.8-13.0) | 10.9 (9.7-12.1) | 15.4 (12.9-18.1) | 4.6 (1.8-8.8) | 10.9 (9.6-12.3) | 10.6 (6.4-16.2) |
Specific HPV types
| |||||||||||
16
| 60.5 (59.5-61.6) | 47.7 (43.3-51.9) | 60.5 (58.6-62.3) | 66.7 (63.3-69.8) | 57.6 (55.3-59.9) | 59.2 (57.5-70.9) | 61.3 (59.4-63.2) | 52.0 (48.4-55.6) | 71.9 (64.2-78.9) | 65.5 (63.4-67.6) | 58.6 (51.0-66.3) |
18
| 10.3 (9.6-10.9) | 22.6 (19.2-26.4) | 11.2 (10.0-12.4) | 10.8 (8.9-13.2) | 11.3 (9.9-12.9) | 9.1 (8.1-10.1) | 8.1 (7.1-9.2) | 12.5 (10.3-15.1) | 6.9 (3.48-11.8) | 7.3 (6.2-8.5) | 19.9 (14.3-26.8) |
31
| 3.7 (3.3-4.1) | 1.9 (0.9-3.4) | 3.0 (2.4-3.8) | 2.8 (1.6-4.0) | 3.2 (2.4-4.1) | 4.9 (4.2-5.7) | 6.5 (5.6-7.6) | 4.3 (3.0-5.9) | 3.4 (1.0-7.1) | 3.4 (2.7-4.3) | 0.7 (0.0-3.2) |
33
| 3.8 (3.4-4.3) | 1.5 (0.6-2.9) | 3.5 (2.8-4.3) | 2.5 (1.6-3.8) | 4.0 (3.1-4.9) | 3.5 (3.2-4.5) | 5.0 (4.3-6.0) | 2.9 (1.9-4.4) | 3.1 (1.0-7.1) | 5.7 (4.7-6.8) | 2.1 (0.4-5.1) |
45
| 5.9 (5.4-6.4) | 9.9 (7.6-12.8) | 5.5 (4.7-6.5) | 7.0 (5.4-9.0) | 4.9 (3.9-6.0) | 6.8 (5.9-7.7) | 3.7 (3.0-4.4) | 7.5 (5.7-9.6) | 5.4 (2.6-10.4) | 3.9 (3.1-4.8) | 5.5 (2.5-9.8) |
52
| 2.8 (2.5-3.2) | 2.6 (1.4-4.3) | 3.8 (3.1-4.6) | 0.8 (0.3-1.7) | 5.3 (4.3-6.4) | 2.7 (2.2-3.3) | 3.0 (2.4-3.7) | 1.6 (0.9-2.9) | 2.9 (1.0-7.1) | 1.9 (1.4-2.6) | 0.6 (0.0-3.2) |
58
| 2.3 (2.0-2.6) | 0.7 (0.2-1.9) | 3.9 (3.2-4.7) | 1.3 (0.7-2.3) | 5.0 (4.1-6.2) | 2.0 (3.3-2.5) | 1.4 (1.0-2.0) | 3.9 (2.6-5.5) | 1.9 (0.39-5.4) | 1.3 (0.9-1.9) | 0.0 (0.0-2.2) |
6
| 0.1 (0.1-0.2) | 0.0 (0.0-0.7) | 0.0 (0.0-0.2) | 0.0 (0.0-0.4) | 0.1 (0.0-0.3) | 0.1 (0.0-0.3) | 0.1 (0.0-0.3) | 0.0 (0.0-0.5) | 0.0 (0.0-2.3) | 0.2 (0.0-0.4) | 1.8 (0.4-5.1) |
11
| 0.0 (0.0-0.1) | 0.0 (0.0-0.7) | 0.0 (0.0-0.2) | 0.0 (0.0-0.4) | 0.1 (0.0-0.3) | 0.0 (0.0-0.2) | 0.0 (0.0-0.2) | 0.0 (0.0-0.5) | 0.0 (0.0-2.3) | 0.0 (0.0-0.2) | 0.0 (0.0-2.2) |
Region | HPV RC (%) | Attributable new cases (N) | ||||
---|---|---|---|---|---|---|
16/18 | 31/33/45/ 52/58 | Year 2012 | Year 2025 | |||
16/18 | 31/33/45/ 52/58 | 16/18 | 31/33/45/52/58 | |||
World
| 70.8 | 18.6 | 391,016 | 102,172 | 444,167 | 116,061 |
Africa
| 70.3 | 16.7 | 60,925 | 14,438 | 80,556 | 19,090 |
Asia
| 71.7 | 19.8 | 232,046 | 63,986 | 259,130 | 71,454 |
Eastern Asia | 68.9 | 22.3 | 95,505 | 30,869 | 100,950 | 32,629 |
Western/Central Asia | 77.5 | 14.5 | 145,101 | 27,073 | 171,333 | 31,967 |
Latin-America
| 68.3 | 19.8 | 48,777 | 14,142 | 54,973 | 15,938 |
South America | 69.4 | 19.6 | 34,632 | 9,799 | 38,783 | 10,973 |
Central America | 64.4 | 20.2 | 13,602 | 4,264 | 15,522 | 4,866 |
North America
| 78.7 | 16.6 | 9,913 | 2,094 | 10,913 | 2,305 |
Europe
| 72.8 | 16.2 | 39,880 | 8,867 | 39,924 | 8,877 |
Oceania
| 78.5 | 8.8 | 1,346 | 152 | 1,587 | 179 |
Precancerous cervical lesions
Region | HPV type | Low grade | High grade | ||||
---|---|---|---|---|---|---|---|
HPV-positive | RC | 95%CI | HPV-positive | RC | 95%CI | ||
Africa
|
HPV-16
| 517 | 16.8 | (13.7-20.3) | 251 | 30.3 | (24.7-36.4) |
HPV-18
| 517 | 8.3 | (6.1-11.0) | 251 | 9.2 | (5.9-13.4) | |
HPV-31
| 432 | 6.5 | (4.4-9.2) | 245 | 8.2 | (5.0-12.3) | |
HPV-33
| 517 | 8.5 | (6.3-11.3) | 235 | 8.9 | (5.6-13.3) | |
HPV-45
| 432 | 4.4 | (2.7-6.8) | 245 | 4.1 | (2.0-7.4) | |
HPV-52
| 432 | 11.8 | (8.9-15.2) | 245 | 11.0 | (7.4-15.6) | |
HPV-58
| 517 | 10.8 | (8.3-13.8) | 251 | 11.2 | (7.5-15.7) | |
Eastern Asia
|
HPV-16
| 2,790 | 21.1 | (19.6-22.6) | 3,693 | 37.9 | (36.4-39.5) |
HPV-18
| 2,790 | 8.3 | (7.3-9.4) | 3,693 | 7.4 | (6.5-8.3) | |
HPV-31
| 2,552 | 4.4 | (3.7-5.3) | 3,596 | 6.9 | (6.1-7.8) | |
HPV-33
| 2,790 | 5.0 | (4.2-5.8) | 3,693 | 9.9 | (9.0-11.0) | |
HPV-45
| 2,549 | 1.2 | (0.8-1.7) | 3,148 | 2.0 | (1.6-2.6) | |
HPV-52
| 2,624 | 18.2 | (16.8-19.8) | 3,469 | 21.3 | (20.0-22.7) | |
HPV-58
| 2,781 | 13.5 | (12.3-14.9) | 3,647 | 19.6 | (18.3-20.9) | |
Western/Central Asia
|
HPV-16
| 237 | 30.8 | (25.0-37.1) | 79 | 68.4 | (56.9-78.4) |
HPV-18
| 237 | 6.8 | (3.9-10.7) | 79 | 6.3 | (2.1-14.2) | |
HPV-31
| 229 | 4.4 | (2.1-7.9) | 63 | 23.8 | (14.0-36.2) | |
HPV-33
| 210 | 7.1 | (4.1-11.8) | 31 | 9.7 | (2.0-25.8) | |
HPV-45
| 189 | 2.1 | (0.6-5.8) | 28 | 7.1 | (0.9-23.5) | |
HPV-52
| 72 | 2.8 | (0.3-9.7) | 20 | 0.0 | (0.0-16.8) | |
HPV-58
| 189 | 6.4 | (3.3-10.8) | 28 | 10.7 | (2.3-28.2) | |
South/Central America
|
HPV-16
| 2,692 | 25.1 | (23.5-26.8) | 1,896 | 52.9 | (50.6-55.1) |
HPV-18
| 2,690 | 6.8 | (5.9-7.9) | 1,886 | 9.4 | (8.2-10.9) | |
HPV-31
| 2,504 | 5.2 | (4.4-6.1) | 1,837 | 10.6 | (9.2-12.1) | |
HPV-33
| 2,517 | 7.5 | (6.5-8.6) | 1,776 | 6.5 | (5.3-7.7) | |
HPV-45
| 2,166 | 4.5 | (3.7-5.5) | 1,669 | 4.8 | (3.8-5.9) | |
HPV-52
| 2,127 | 5.1 | (4.2-6.1) | 1,587 | 6.3 | (5.2-7.6) | |
HPV-58
| 2,220 | 6.9 | (5.8-8.0) | 1,589 | 9.5 | (8.1-11.1) | |
North America
|
HPV-16
| 5,532 | 24.7 | (23.6-25.6) | 4,598 | 56.7 | (55.3-58.2) |
HPV-18
| 5,532 | 9.5 | (8.7-10.3) | 4,598 | 9.6 | (8.8-10.5) | |
HPV-31
| 5,532 | 8.9 | (8.1-9.6) | 4,598 | 13.1 | (12.1-14.1) | |
HPV-33
| 5,317 | 4.2 | (3.7-4.8) | 4,598 | 7.6 | (6.9-8.4) | |
HPV-45
| 5,415 | 5.6 | (5.0-6.2) | 4,397 | 4.8 | (4.2-5.5) | |
HPV-52
| 4,839 | 10.7 | (9.9-11.6) | 4,205 | 10.3 | (9.4-11.3) | |
HPV-58
| 5,213 | 7.6 | (6.9-8.3) | 4,397 | 6.8 | (6.1-7.6) | |
Europe
|
HPV-16
| 14,319 | 25.9 | (25.2-26.6) | 8,348 | 54.4 | (53.3-55.5) |
HPV-18
| 14,256 | 9.1 | (8.6-9.6) | 8,214 | 7.7 | (7.2-8.3) | |
HPV-31
| 13,166 | 12.5 | (12.0-13.1) | 7,930 | 12.4 | (11.6-13.1) | |
HPV-33
| 13,186 | 6.6 | (6.2-7.1) | 7,844 | 9.4 | (8.7-10.0) | |
HPV-45
| 10,472 | 4.6 | (4.2-5.1) | 6,244 | 3.8 | (3.3-4.3) | |
HPV-52
| 9,577 | 8.3 | (7.8-8.9) | 6,067 | 7.2 | (6.6-7.9) | |
HPV-58
| 10,489 | 6.7 | (6.2-7.2) | 6,278 | 5.8 | (5.2-6.4) | |
Oceania
|
HPV-16
| 385 | 24.7 | (20.5-29.3) | 924 | 53.9 | (50.6-57.2) |
HPV-18
| 385 | 8.6 | (6.0-11.8) | 924 | 9.6 | (7.8-11.7) | |
HPV-31
| 385 | 13.3 | (10.0-17.0) | 924 | 12.3 | (10.3-14.6) | |
HPV-33
| 385 | 5.7 | (3.6-8.5) | 924 | 7.9 | (6.2-9.8) | |
HPV-45
| 385 | 6.5 | (4.3-9.4) | 924 | 4.2 | (3.0-5.7) | |
HPV-52
| 385 | 11.4 | (8.4-15.0) | 924 | 12.2 | (10.2-14.5) | |
HPV-58
| 385 | 9.1 | (6.4-12.4) | 924 | 5.8 | (4.4-7.6) |